Critical Life K23 Administrative Supplement

关键生活 K23 行政补充

• 批准号: 10853274
• 负责人: Brooke Klatt
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10853274
• 关键词: Address; Administrative Supplement; Adult; Age; Behavioral; Blurred vision; Caring; Case Series; Charities; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Cognition; Cognitive; Complex; Coping Skills; Crowding; Data Analyses; Deterioration; Development Plans; Dizziness; Doctor of Philosophy; Effectiveness of Interventions; Elderly; Environment; Environmental Risk Factor; Epidemiologic Methods; Equilibrium; Equipment and supply inventories; Feedback; Foundations; Fright; Functional disorder; Future; Gait; Impaired cognition; Impairment; Incidence; Individual; Intervention; Intervention Trial; Interview; K-Series Research Career Programs; Life; Measures; Mental Health; Methodology; Moods; Motion; Nausea; Outcome; Patients; Perception; Persons; Population; Positioning Attribute; Predisposing Factor; Protocols documentation; Provider; Quality of life; Recovery; Rehabilitation therapy; Reporting; Research; Research Priority; Science; Scientist; Sensorimotor functions; Series; Structure; Testing; Theoretical model; Training; Translating; United States; Visual; Vulnerable Populations; behavioral clinical trial; career development; cohort; comorbidity; coping; design; disability; effective intervention; efficacy evaluation; efficacy testing; experience; fall risk; gaze; improved; insight; instrument; intervention refinement; longitudinal analysis; medical attention; multidisciplinary; multimodality; novel; physical therapist; rehabilitation science; rehabilitative care; remediation; skills; therapy development

Current vestibular rehabilitation intervenes upon vestibular impairments (balance, gaze stability, and dizziness). Activity and participation are reduced in people with vestibulopathy, but are not addressed in vestibular rehabilitation protocols. Approximately 40% of people with vestibulopathy do not fully recover and transition to a state of chronic disability, which often results from reductions in activity and participation, and. Evidence from rehabilitation science within other populations suggest that return to full activity and participation is related to functional mobility status, and also several behavioral, personal, and environmental factors. Similarly, we suspect that cognitive, mood, and personal (confidence, coping, and fear avoidance) factors that are modifiable, may impact activity and participation in people with vestibulopathy. It is also unknown whether improvements in activity and participation are related to remediation of impairments following vestibular rehabilitation. Activity and participation represent important domains to target to optimize outcomes and reduce chronic disability. This career development award will establish Dr. Brooke Klatt as a clinical scientist with expertise in 3 primary domains: (1) cohort design and analysis; (2) qualitative methodology, and (3) complex rehabilitation intervention development and behavioral clinical trial methodology. Dr. Klatt has assembled a multi-disciplinary team of experts in rehabilitation intervention development and implementation (Jennifer Brach, PhD, PT and Elizabeth Skidmore, PhD, OTR/L), activity and participation assessment and epidemiological methods (Andrea Rosso, PhD, MPH), behavioral impacts on vestibular recovery (Jeffrey Staab, MD), and clinical trial methodology (Megan Hamm, PhD and Charity Patterson, PhD, MSPH). Dr. Klatt will conduct a series of studies to develop an enhanced vestibular intervention that will augment current vestibular rehabilitation targeted to improve activity and participation. She will investigate whether impairments (balance, gait, gaze stability, dizziness, cognition, and mood) as well as personal factors (confidence, coping skills, and fear avoidance) are related to activity and participation in people with vestibulopathy (Aim 1), and she will determine if reductions in vestibular impairment is related to improvements in activity and participation (Aim 2). She will use stakeholder input from clinicians and patients to determine the delivery features that show the greatest promise for improving activity and participation in people with vestibulopathy (Aim 3). Dr. Klatt’s is plan to develop effective interventions to enhance current vestibular rehabilitation addresses the NCMRR research priorities to mitigate acquisition of secondary conditions by using a multimodal approach to promote vestibular plasticity and sensorimotor function. The proposed training will be the foundation for a future R01 application examining the efficacy of the enhanced vestibular intervention to improve activity and participation and the quality of life for individuals with vestibulopathy.

目前的前庭康复间隔在前庭障碍（平衡，凝视稳定性和 头晕）。患有前庭病的人减少了活动和参与，但没有解决 前庭康复方案。大约40％的前庭病患者无法完全康复，并且 过渡到慢性残疾状态，这通常是由于活动和参与的减少而导致的。 其他人群中康复科学的证据表明，重返全面活动和参与 与功能性移动状况以及几种行为，个人和环境因素有关。 同样，我们怀疑认知，情绪和个人（自信，应对和避免恐惧）因素 可修改，可能会影响前庭病患者的活动并参与。也未知是否 活动和参与的改善与前庭后的损害的补救有关 康复。活动和参与代表着目标的重要领域，以优化结果并减少 慢性残疾。该职业发展奖将建立布鲁克·克拉特博士，担任 3个主要领域的专业知识：（1）队列设计和分析； （2）定性方法和（3）复杂 康复干预开发和行为临床试验方法。克拉特博士集会了 康复干预开发和实施专家的多学科团队（Jennifer） Brach，PhD，PT和Elizabeth Skidmore，PhD，OTR/L），活动和参与评估以及 流行病学方法（Andrea Rosso，PhD，MPH），行为对前庭恢复的影响（Jeffrey Staab，MD）和临床试验方法（Megan Hamm，PhD和Charity Patterson，PhD，MSPH）。克拉特博士 将进行一系列研究以开发增强的前庭干预措施，以增加电流 前庭康复目标旨在改善活动和参与。她将调查是否损害 （平衡，步态，目光的稳定，头晕，认知和情绪）以及个人因素（自信，应对 技能和恐惧避免）与患有前庭病患者的活动和参与有关（AIM 1）和 她将确定减少前庭障碍是否与活动和参与的改善有关 （目标2）。她将使用临床医生和患者的利益相关者的意见来确定显示的交付功能 改善活动患者的活动和参与患者的最大希望（AIM 3）。克拉特博士是 计划制定有效的干预措施以增强目前的前庭康复解决NCMRR 通过使用多模式的方法来促进的研究优先级以减轻次要条件的获得 前庭塑性和感觉运动功能。拟议的培训将是未来R01的基础 申请检查增强的前庭干预效率以改善活动和参与 以及患有前庭病的人的生活质量。