Cognitive Neuroscience of Development and Aging (CONDA) Center

发育与衰老认知神经科学 (CONDA) 中心

• 批准号: 10853737
• 负责人: Anna Dunaevsky
• 金额: $ 93.91万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10853737
• 关键词: Acceleration; Acetamides; Address; Affect; Affinity; Aging; American; Animals; Area; Astrocytes; Attenuated; Behavior assessment; Behavioral Assay; Binding; Biological Assay; Blood flow; Brain; Cells; Centers of Research Excellence; Cerebral Ischemia; Cessation of life; Clinical; Cognition; Cognitive deficits; Communities; Core Facility; Data; Data Set; Dedications; Development; Docking; Emergency treatment; Ensure; Equipment; Evaluation; Faculty; Fellowship; Financial Support; Functional disorder; Funding; Gene Expression Alteration; Genetic Transcription; Government; Grant; Heart Arrest; Hippocampus; Histology; Hospitals; Human; Hydrolysis; Impaired cognition; In Vitro; Individual; Infiltration; Inflammatory; Innate Immune Response; Institution; Internships; Ischemia; Laboratories; Lead; Life; Longevity; Magnetic Resonance Imaging; Massive Parallel Sequencing; Medical; Medical center; Membrane; Mentors; Methods; Microglia; Modification; Molecular; Monitor; Mutagens; Myelogenous; Myeloid Cells; Nebraska; Nerve Degeneration; Neurons; Neurosciences; Neurosciences Research; Oxygen; Participant; Pathology; Pathway Analysis; Pathway interactions; Pattern; Peptides; Phenotype; Pilot Projects; Population; Postdoctoral Fellow; Quality Control; Rattus; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Role; Sampling; Scientist; Series; Signal Transduction; Structure; Structure-Activity Relationship; Support System; System; Techniques; Testing; Tissues; Toxic effect; Training; United States National Institutes of Health; Universities; affective neuroscience; analog; antagonist; boys; brain cell; brain research; career development; cell type; cognitive development; cognitive function; cognitive neuroscience; cohort; design; drug candidate; effective therapy; feasibility testing; frontier; heart function; hippocampal pyramidal neuron; improved; in vivo Model; inhibitor; innovation; member; neuroimaging; neuroinflammation; neuron loss; neuroregulation; new therapeutic target; next generation; novel; novel therapeutics; preservation; prevent; primary outcome; programs; receptor; recruit; single-cell RNA sequencing; small molecule; therapeutically effective; tool; training opportunity; transcriptome; transcriptome sequencing; transcriptomics

Contact PD/PI: Wilson, Tony W Abstract/Summary: Overall Component This application for a Center of Biomedical Research Excellence (COBRE) would initiate a formal Center to lead, support, and expand neuroimaging and clinical cognitive neuroscience research in Nebraska, with an emphasis on lifespan development. It is an opportune moment for human neuroscience research in the Omaha community, regionally, and across the world, with many new research tools and government initiatives intended to illuminate the next frontier of biomedicine. The proposed Cognitive Neuroscience of Development and Aging (CONDA) Center will provide critical resources and support to faculty from four institutions: the University of Nebraska Medical Center (UNMC), the Boys Town National Research Hospital, the University of Nebraska – Omaha, and Creighton University. The Administrative Core of the CONDA Center will be housed at UNMC, which is less than two miles from each of the other institutions, and will be comprised of Training, Evaluation, Engagement, Administration, and Mentoring areas (i.e., the TEEAM Core). The new CONDA Center will also include a state- of-the-art Neuroimaging Acquisition and Analysis Core, as well as extensive support for four primary COBRE research projects led by a promising group of NIH-defined early-stage investigators. Upon initiation of the Center, the TEEAM Core would immediately implement a series of new programs that are designed to develop human cognitive neuroscience on the CONDA Campus and across the region. The TEEAM Core would also rapidly implement a comprehensive research support structure that includes the Neuroimaging Core facility, training opportunities, pilot projects and mini-grants programs, a new seminar series, postdoctoral fellowships, intern- ships for growing temporary and long-term laboratory staffing, and a participant registry to enhance recruitment. In parallel, the TEEAM Core would promote the successful launch of the primary COBRE research projects and, through a mentoring network approach, implement a career development and evaluation support system to monitor progress and ensure Junior PIs and their mentoring teams reach critical milestones. As per the new research core, the Neuroimaging Acquisition and Analysis Core facility would be the only core dedicated to human brain research in the state of Nebraska, and would provide regional scientists with state-of-the-art tools for neuroimaging and neuromodulation, including research-dedicated MRI and MEG systems. The new Center would also receive exceptional institutional support, including financial support for CONDA programs, major equipment expenses, and Core staffing. The overall CONDA team includes an established group of PIs in neuro- imaging, brain dynamics, aging, and brain and cognitive development, as well as a strong cohort of emerging junior investigators using innovative cognitive and affective neuroscience methods to address major questions in human neuroscience across the lifespan. These junior scientists were all hired in the past three years, and this new wealth of concentrated local expertise has primed us for a trajectory of accelerated development of neuro- science and neuroimaging toward national prominence, an aim for which the new CONDA Center will be integral. Page 85 Project Summary/Abstract

联系PD/PI：Wilson、Tony W 摘要/总结：整体组件 这一生物医学研究卓越中心（COBRE）的申请将启动一个正式的中心， 支持和扩大内布拉斯加州的神经成像和临床认知神经科学研究，重点是 寿命的发展。对于奥马哈社区的人类神经科学研究来说，这是一个合适的时机， 在区域和世界各地，许多新的研究工具和政府倡议旨在阐明 生物医学的下一个前沿发展与衰老的认知神经科学（Cognitive Neuroscience of Development and Aging，CONDA） 中心将为来自内布拉斯加大学等四所院校的教师提供关键资源和支持 医学中心（UNMC），男孩镇国家研究医院，内布拉斯加大学奥马哈分校， 克雷顿大学。该中心的行政核心将设在联合国军事委员会， 距离其他机构各两英里，将由培训，评估，参与， 管理和指导领域（即，TEEAM核心）。新的康达中心还将包括一个国家- 最先进的神经成像采集和分析核心，以及对四个主要COBRE的广泛支持 由NIH定义的早期研究人员组成的一个有前途的小组领导的研究项目。中心成立后， TEEAM核心将立即实施一系列旨在开发人类的新计划， 认知神经科学在康达校园和整个地区。TEEAM核心也将迅速 实施全面的研究支持结构，包括神经影像核心设施，培训 机会，试点项目和小额赠款计划，新的研讨会系列，博士后奖学金，实习生， 增加临时和长期实验室工作人员的船舶，以及参与者登记册，以加强招聘。 与此同时，TEEAM核心将促进COBRE主要研究项目的成功启动， 通过辅导网络办法，实施职业发展和评价支助系统， 监控进度，确保初级PI及其指导团队达到关键里程碑。按照新的 神经影像采集和分析核心设施将是唯一致力于研究的核心， 人类大脑研究在内布拉斯加州，并将提供最先进的工具，区域科学家 用于神经成像和神经调节，包括研究专用MRI和MEG系统。新中心 还将获得特殊的机构支持，包括对CONDA计划的财政支持， 设备费用和核心人员。整个CONDA团队包括一组既定的神经系统专业研究员， 成像，脑动力学，衰老，大脑和认知发展，以及一个强大的新兴队列， 初级研究人员使用创新的认知和情感神经科学方法来解决主要问题 在人类神经科学中的应用。这些年轻的科学家都是在过去三年里被雇佣的， 集中的本地专业知识的新财富为我们加速发展神经系统的轨迹做好了准备， 科学和神经影像走向全国突出，新的康达中心的目标将是不可或缺的。 第85页 项目总结/摘要