Cognitive Neuroscience of Development and Aging (CONDA) Center

发育与衰老认知神经科学 (CONDA) 中心

• 批准号: 10853737
• 负责人: Anna Dunaevsky
• 金额: $ 93.91万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10853737
• 关键词: Acceleration; Acetamides; Address; Affect; Affinity; Aging; American; Animals; Area; Astrocytes; Attenuated; Behavior assessment; Behavioral Assay; Binding; Biological Assay; Blood flow; Brain; Cells; Centers of Research Excellence; Cerebral Ischemia; Cessation of life; Clinical; Cognition; Cognitive deficits; Communities; Core Facility; Data; Data Set; Dedications; Development; Docking; Emergency treatment; Ensure; Equipment; Evaluation; Faculty; Fellowship; Financial Support; Functional disorder; Funding; Gene Expression Alteration; Genetic Transcription; Government; Grant; Heart Arrest; Hippocampus; Histology; Hospitals; Human; Hydrolysis; Impaired cognition; In Vitro; Individual; Infiltration; Inflammatory; Innate Immune Response; Institution; Internships; Ischemia; Laboratories; Lead; Life; Longevity; Magnetic Resonance Imaging; Massive Parallel Sequencing; Medical; Medical center; Membrane; Mentors; Methods; Microglia; Modification; Molecular; Monitor; Mutagens; Myelogenous; Myeloid Cells; Nebraska; Nerve Degeneration; Neurons; Neurosciences; Neurosciences Research; Oxygen; Participant; Pathology; Pathway Analysis; Pathway interactions; Pattern; Peptides; Phenotype; Pilot Projects; Population; Postdoctoral Fellow; Quality Control; Rattus; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Role; Sampling; Scientist; Series; Signal Transduction; Structure; Structure-Activity Relationship; Support System; System; Techniques; Testing; Tissues; Toxic effect; Training; United States National Institutes of Health; Universities; affective neuroscience; analog; antagonist; boys; brain cell; brain research; career development; cell type; cognitive development; cognitive function; cognitive neuroscience; cohort; design; drug candidate; effective therapy; feasibility testing; frontier; heart function; hippocampal pyramidal neuron; improved; in vivo Model; inhibitor; innovation; member; neuroimaging; neuroinflammation; neuron loss; neuroregulation; new therapeutic target; next generation; novel; novel therapeutics; preservation; prevent; primary outcome; programs; receptor; recruit; single-cell RNA sequencing; small molecule; therapeutically effective; tool; training opportunity; transcriptome; transcriptome sequencing; transcriptomics

Contact PD/PI: Wilson, Tony W Abstract/Summary: Overall Component This application for a Center of Biomedical Research Excellence (COBRE) would initiate a formal Center to lead, support, and expand neuroimaging and clinical cognitive neuroscience research in Nebraska, with an emphasis on lifespan development. It is an opportune moment for human neuroscience research in the Omaha community, regionally, and across the world, with many new research tools and government initiatives intended to illuminate the next frontier of biomedicine. The proposed Cognitive Neuroscience of Development and Aging (CONDA) Center will provide critical resources and support to faculty from four institutions: the University of Nebraska Medical Center (UNMC), the Boys Town National Research Hospital, the University of Nebraska – Omaha, and Creighton University. The Administrative Core of the CONDA Center will be housed at UNMC, which is less than two miles from each of the other institutions, and will be comprised of Training, Evaluation, Engagement, Administration, and Mentoring areas (i.e., the TEEAM Core). The new CONDA Center will also include a state- of-the-art Neuroimaging Acquisition and Analysis Core, as well as extensive support for four primary COBRE research projects led by a promising group of NIH-defined early-stage investigators. Upon initiation of the Center, the TEEAM Core would immediately implement a series of new programs that are designed to develop human cognitive neuroscience on the CONDA Campus and across the region. The TEEAM Core would also rapidly implement a comprehensive research support structure that includes the Neuroimaging Core facility, training opportunities, pilot projects and mini-grants programs, a new seminar series, postdoctoral fellowships, intern- ships for growing temporary and long-term laboratory staffing, and a participant registry to enhance recruitment. In parallel, the TEEAM Core would promote the successful launch of the primary COBRE research projects and, through a mentoring network approach, implement a career development and evaluation support system to monitor progress and ensure Junior PIs and their mentoring teams reach critical milestones. As per the new research core, the Neuroimaging Acquisition and Analysis Core facility would be the only core dedicated to human brain research in the state of Nebraska, and would provide regional scientists with state-of-the-art tools for neuroimaging and neuromodulation, including research-dedicated MRI and MEG systems. The new Center would also receive exceptional institutional support, including financial support for CONDA programs, major equipment expenses, and Core staffing. The overall CONDA team includes an established group of PIs in neuro- imaging, brain dynamics, aging, and brain and cognitive development, as well as a strong cohort of emerging junior investigators using innovative cognitive and affective neuroscience methods to address major questions in human neuroscience across the lifespan. These junior scientists were all hired in the past three years, and this new wealth of concentrated local expertise has primed us for a trajectory of accelerated development of neuro- science and neuroimaging toward national prominence, an aim for which the new CONDA Center will be integral. Page 85 Project Summary/Abstract

联系PD/PI：Wilson，Tony W 摘要/摘要：整体组件 该申请卓越生物医学研究中心（COBRE）将启动一个正式的中心，以领导， 支持并扩大内布拉斯加州的神经影像学和临床认知神经科学研究，重点 关于寿命的发展。这是奥马哈社区人类神经科学研究的机会时刻， 在区域以及世界各地，旨在阐明许多新的研究工具和政府倡议 提出的发展和衰老的认知神经科学（CONDA） 中心将为四个机构的教师提供关键的资源和支持：内布拉斯加州大学 医疗中心（UNMC），内布拉斯加州大学男孩镇国家研究医院 - 奥马哈和 克雷顿大学。康达中心的行政核心将安置在UNMC，少于 距离其他机构两英里，将完成培训，评估，参与， 管理和指导领域（即Teeam Core）。新的康达中心还将包括一个州 - 艺术神经影像学的获取和分析核心，以及对四个主要毛绒的广泛支持 由一群有前途的NIH定义的早期研究人员领导的研究项目。根据中心的主动 Teeam Core将立即实施一系列旨在发展人类的新程序 康达校园和整个地区的认知神经科学。 Teeam核心也将迅速 实施全面的研究支持结构，包括神经影像学核心设施，培训 机会，试点项目和迷你奖励计划，新的半段系列，博士后奖学金，实习生 - 发展临时和长期实验室人员配备的船，以及参与者注册中心，以增强招聘。 同时，Teeam Core将促进主要的毛绒研究项目的成功启动，以及 通过心理网络方法，将职业发展和评估支持系统实施 监视进度并确保初级PI及其心理团队达到关键的里程碑。根据新的 研究核心，神经影像学的获取和分析核心设施将是唯一致力于 内布拉斯加州州的人脑研究，并将为区域科学家提供最先进的工具 用于神经影像学和神经调节，包括研究的MRI和MEG系统。新中心 还将获得卓越的机构支持，包括对Conda计划的财务支持，主要 设备费用和核心人员配备。整个Conda团队包括一群既定的PIS in Neuro-- 成像，大脑动力学，衰老，大脑和认知发展，以及强大的新兴人群 初级研究人员使用创新的认知和情感神经科学方法来解决主要问题 在整个生命周期的人类神经科学中。这些初级科学家在过去三年中都被录用了，这 新的集中的本地专业知识为我们提供了培训，以加速神经发展的发展 科学和神经影像朝着民族知名度，这是新的康达中心将是不可或缺的目标。 第85页 项目摘要/摘要