Wyoming IDeA Networks for Biomedical Research Excellence Phase 4

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PROJECT SUMMARY The Wyoming IDeA Networks for Biomedical Research Excellence INBRE aims to establish a statewide network for biomedical research and excellence. Specifically, WY INBRE aims are to: 1) build the multidisciplinary research network with scientific foci that will strengthen biomedical research expertise and infrastructure at the University of Wyoming and its partner institutions; 2) build the research base and capacity of the University of Wyoming and its partner institutions by providing research support to faculty, postdoctoral fellows and graduate students; 3) provide research opportunities for undergraduate students; 4) enhance the science and technology knowledge of the state's workforce; and 5) expand Wyoming research opportunities across the Western IDeA Region. Consistent with these goals, this Administrative Supplement (NOT-GM-23-034) aims to answer significant multidisciplinary biomedical research questions using complementary, cutting-edge approaches. Our team science approach will combine the expertise and diverse disciplinary perspectives of Dr. Nicole Bedford (behavioral neuroscience), Dr. Danielle Bruns (cardiac aging), and Dr. Emily Schmitt (circadian biology). Together, we will address a complex basic/translational research question using innovative technology. We aim to understand the mechanisms of age-related nocturia, a condition with high morbidity in the aging population. Specifically, we will dissect the 1) neurobehavioral and 2) cardiorenal circadian mechanisms of nocturia. Last, we will 3) test the potential rescue of the nocturia phenotype by chronotimed exercise – a novel therapy with significant translational potential. Successful accomplishment of this goal necessitates a team science effort. Together, the proposal will not only address significant biomedical questions in aging populations, but our strong collaborative team will generate preliminary data for extramural funding applications. The work proposed in this supplement also includes the contributions of graduate and undergraduate research assistants, who are necessary to expand biomedical research capacity in Wyoming.