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Wyoming IDeA Networks for Biomedical Research Excellence Phase 4

怀俄明州 IDeA 生物医学研究卓越网络第 4 阶段

基本信息

批准号：
10850720
负责人：
Robert Scott Seville
金额：
$ 54.75万
依托单位：
UNIVERSITY OF WYOMING
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10850720
关键词：
Acceleration Address Administrative Supplement Adult Affect Age Aging Animal Model Animals Atrial Natriuretic Factor Attenuated Behavior Behavioral Behavioral Paradigm Biological Biomedical Research Bladder Brain Cardiac Cardiovascular Diseases Circadian Dysregulation Circadian Rhythms Circadian desynchrony Complex Data Development Diagnosis Disease Education Elderly Exercise Extramural Activities Faculty Fracture Functional disorder Funding Gene Expression Goals Health Heart Homeostasis Hypertension Incontinence Individual Infrastructure Institution Interdisciplinary Study Kidney Knowledge Lower urinary tract Midbrain structure Modeling Molecular Morbidity - disease rate Mus Neurosciences Nocturia Outcome Pathway interactions Peripheral Persons Phase Phenotype Piezo 1 ion channel Polyuria Population Postdoctoral Fellow Process Production Reporting Research Research Assistant Research Personnel Research Support Resources Risk Factors Science Sensory Signal Transduction Sleep Stimulus Stretch Receptors Symptoms Technology Testing Therapeutic Therapeutic Intervention Tissues Translational Research United States Universities Urination Urine Water Work Wyoming absorption age related aged aging population base circadian circadian biology circadian pacemaker comorbidity effective therapy efficacy evaluation fall risk graduate student human old age (65+)innovation innovative technologies insight multidisciplinary neural neurobehavioral neuromechanism novel novel therapeutics preclinical study sedentary sensory feedback signal processing targeted treatment therapeutic target tool translational model translational potential treatment strategy undergraduate research undergraduate research experience undergraduate student

项目摘要

PROJECT SUMMARY The Wyoming IDeA Networks for Biomedical Research Excellence INBRE aims to establish a statewide network for biomedical research and excellence. Specifically, WY INBRE aims are to: 1) build the multidisciplinary research network with scientific foci that will strengthen biomedical research expertise and infrastructure at the University of Wyoming and its partner institutions; 2) build the research base and capacity of the University of Wyoming and its partner institutions by providing research support to faculty, postdoctoral fellows and graduate students; 3) provide research opportunities for undergraduate students; 4) enhance the science and technology knowledge of the state's workforce; and 5) expand Wyoming research opportunities across the Western IDeA Region. Consistent with these goals, this Administrative Supplement (NOT-GM-23-034) aims to answer significant multidisciplinary biomedical research questions using complementary, cutting-edge approaches. Our team science approach will combine the expertise and diverse disciplinary perspectives of Dr. Nicole Bedford (behavioral neuroscience), Dr. Danielle Bruns (cardiac aging), and Dr. Emily Schmitt (circadian biology). Together, we will address a complex basic/translational research question using innovative technology. We aim to understand the mechanisms of age-related nocturia, a condition with high morbidity in the aging population. Specifically, we will dissect the 1) neurobehavioral and 2) cardiorenal circadian mechanisms of nocturia. Last, we will 3) test the potential rescue of the nocturia phenotype by chronotimed exercise – a novel therapy with significant translational potential. Successful accomplishment of this goal necessitates a team science effort. Together, the proposal will not only address significant biomedical questions in aging populations, but our strong collaborative team will generate preliminary data for extramural funding applications. The work proposed in this supplement also includes the contributions of graduate and undergraduate research assistants, who are necessary to expand biomedical research capacity in Wyoming.

项目概要怀俄明州 IDeA 卓越生物医学研究网络 INBRE 旨在建立一个全州网络致力于生物医学研究和卓越。具体来说，WY INBRE 的目标是：1）建立多学科具有科学重点的研究网络，将加强生物医学研究专业知识和基础设施怀俄明大学及其合作机构； 2）建设大学的研究基础和能力怀俄明州及其合作机构为教师、博士后研究员和研究生提供研究支持学生; 3）为本科生提供研究机会； 4）提升科学技术对国家劳动力的了解； 5) 在西部 IDeA 中扩大怀俄明州的研究机会地区。与这些目标一致，本行政补充文件 (NOT-GM-23-034) 旨在回答使用互补的尖端方法解决重要的多学科生物医学研究问题。我们的团队科学方法将结合 Nicole Bedford 博士的专业知识和不同学科观点（行为神经科学）、Danielle Bruns 博士（心脏衰老）和 Emily Schmitt 博士（昼夜节律生物学）。我们将共同利用创新技术解决复杂的基础/转化研究问题。我们的目标了解与年龄相关的夜尿症的机制，这是一种在老龄化人口中发病率较高的疾病。具体来说，我们将剖析夜尿的 1) 神经行为和 2) 心肾昼夜节律机制。最后的，我们将 3) 测试通过计时锻炼对夜尿症表型的潜在挽救作用——这是一种新疗法巨大的转化潜力。成功实现这一目标需要团队的科学努力。总之，该提案不仅将解决人口老龄化中的重大生物医学问题，而且还将解决我们强大的合作团队将为外部资金申请生成初步数据。本报告中提出的工作补充材料还包括研究生和本科生研究助理的贡献，他们是扩大怀俄明州生物医学研究能力是必要的。