Center for digestive and liver diseases

总体描述（由申请人提供）： 宾夕法尼亚大学消化系统疾病研究核心中心（DDRCC），名为消化系统和肝脏疾病分子研究中心，自1997年以来一直获得资助。这项相互竞争的拨款提案继续联合来自多个学科的研究人员进行基于消化和肝脏的综合研究。该研究基地包括以下3个相互关联的科学重点或亲和力组的研究人员：（1）发育生物学和遗传学，（2）免疫生物学和宿主反应，（3）细胞生长和分化。该研究基地由55名成员组成，具有相互关联的科学计划，代表了宾夕法尼亚大学的一系列部门，中心，研究所和学校。此外，还有一个由14名准成员组成的年轻调查员基地，他们自己的个人方案和职业发展由中心培养。中心成员获得了30，650，813美元的消化系统疾病相关NIH研究资金的支持，其中42.12%是通过NIDDK。我们中心的一个基本目标是促进跨学科的研究，导致形成，调节和操作消化道，胰腺和肝脏器官及其组织组织在健康和疾病的分子和生化过程的合作理解。在这种情况下，我们的目的是利用该中心作为一种手段，通过吸引和从事消化和肝脏研究的既定研究人员来开发创新思想。该中心的一个同样重要的目标是在这项研究中培养年轻的研究人员。四个非常成功的科学核心设施旨在提供消化特定的服务，以促进合作研究：形态学，分子生物学/基因表达，转基因和嵌合小鼠，细胞培养。行政核心指导中心的财政和组织方面，包括科学核心，试点和可行性补助金计划，学术充实计划和内部/外部咨询委员会的协调和宣传。试点和可行性补助金计划在促进消化研究的新研究者方面非常成功。根据其与中心科学重点的相关性和促进年轻研究者消化系统研究的优先级，选择了四个提案：（1）蛋白酪氨酸磷酸酶1B（PTP 1B）在肥胖相关胰岛素抵抗和非酒精性脂肪肝（NAFLD）中的作用;（2）Barrett食管的器官型培养模型;（3）造血对肠道血管系统的贡献;（4）蛋白酪氨酸磷酸酶1B（PTP 1B）在肥胖相关胰岛素抵抗和非酒精性脂肪肝（NAFLD）中的作用。（4）p53/IGFBP 1调控通路与肝癌。我们的DDRCC的总功能保持在生物医学科学的最前沿消化和肝脏研究计划。

DESCRIPTION, OVERALL (provided by applicant): The University of Pennsylvania's Digestive Diseases Research Core Center (DDRCC), entitled Center for Molecular Studies in Digestive and Liver Diseases, has been funded since 1997. This competing grant proposal continues to unite investigators from multiple disciplines for integrated digestive and liver based research. The research base includes investigators organized in the following 3 interrelated scientific focus or affinity groups: (1) Development biology and genetics, (2) Immunobiology and host responses, and (3) Cell growth and differentiation. The research base consists of 55 members, with interrelated scientific programs, and represents a spectrum of departments, Centers, Institutes and Schools at the University of Pennsylvania. In addition, there is a young investigator base of 14 associate members, whose own individual programs and career development are nurtured by the Center. Center members are supported by $30,650,813 in digestive-diseases related NIH research funding, of which 42.12% is through NIDDK. A fundamental goal of our Center is to foster interdisciplinary research that leads to a cooperative understanding of the molecular and biochemical processes that form, regulate, and operate digestive tract, pancreatic and liver organs and their organizing tissues in health and disease. In this context, our intent is to utilize the Center as a means to develop innovative ideas by attracting and engaging established investigators into digestive and liver research. An equally important goal of the Center is to develop young investigators in this research. Four highly successful Scientific Core facilities are designed to provide digestive-specific services for the stimulation of collaborative research: Morphology, Molecular Biology/Gene Expression, Transgenic and Chimeric Mouse, and Cell Culture. An Administrative Core directs the fiscal and organizational aspects of the Center, including the coordination and publicity of the Scientific Cores, Pilot and Feasibility Grant Program, Academic Enrichment Program and Internal/External Advisory Committees. The Pilot and Feasibility Grant Program has been extremely successful for the promotion of new investigators in digestive research. Four proposals were selected based on their relevance to the Center's scientific focus and the priority of promoting digestive research among young investigators: (1) Role of protein-tyrosine phosphatase 1B (PTP1B) in obesity-related insulin resistance and non-alcoholic fatty liver disease (NAFLD); (2) An organotypic culture model of Barrett's esophagus; (3) Hematopoietic contribution to the gut vasculature; and (4) A p53/IGFBP1 regulatory circuit and liver cancer. Our DDRCC's aggregate functions maintain the digestive and liver research programs at the forefront of biomedical science.