Administrative and Biostatistics Core

核心A摘要 核心A的行政构成部分将在行政、管理和其他领域提供全面和协调一致的支助， 计划项目的财政和方案方面。它还将与纽约大学 宾夕法尼亚州，Dana Farber癌症研究所，Fox Chase癌症中心和国家癌症研究所 （NCI）。行政部分在地理上靠近科学核心设施， 宾夕法尼亚大学的项目领导者的实验室，将服务于许多组织和财政职能。这些包括 每月预算报告的生成和分析，与医学院的研究服务接口， 协调临床/翻译项目，并完成NCI要求。此外，行政 该构成部分将继续协调与项目和核心设施领导人的每月会议;每周会议 核心设施会议;定期研究研讨会/期刊俱乐部/实验室会议;维持图书馆， 通讯和网站;并在大学和医学院（特别是 因为它涉及到内部咨询委员会（IAB），以及区域和国家。重要的是，核心将 结合外部咨询委员会的审查，组织年度会议/务虚会。所有 IAB和EAB报告将由核心组织，并与院长（拉里·詹姆森博士）分享， 艾布拉姆森癌症中心主任（博士池党），DFCI（博士格里芬）和NCI。作为补充措施， 行政部门将组织关于赠款撰写、手稿撰写和职业发展的讲习班 为学生，博士后研究员和初级教师在程序项目。它将继续扩大 分子病理学/成像核心（MPIC）和分子生物学核心的人体组织库工作 (MBC)，促进项目和核心产生的数据库，确保新基因组学的适当性， 通过分子生物学核心的生物信息学支持，并整合生物统计学组件。那里 建立了密切的沟通、互动和协同合作 与DFCI的项目3通过直接双向访问（由项目负责人以及实验室人员， 后者来自DFCI，用于MPIC和MBC的指导），每月P01会议（使用当前捕获和视频 技术），每周电话会议，和行政组成部分将推进创新和远- 实现计划项目所阐明和设想的目标。总体而言，行政部门 将加强该计划项目的智力、科学、结构和财政组成部分。单独 Rustgi博士和Hay女士在管理和确保主题方面拥有丰富的经验。 项目和核心之间的整合。 生物统计子组件将由核心A副主任Gimotty博士领导，他患有大量癌症 生物统计经验和联合出版物作为丰富的协同作用的证据， Gimotty博士将在以下方面提供她在癌症生物统计学方面的专业知识和经验 1.实验和临床研究的设计。B）统计建模和统计分析，以评估 每个项目的研究假设。c）解释研究数据并与研究人员合作， 作出科学和统计上适当的陈述，并协助编制科学报告， 摘要、演示文稿和手稿。（d）为解决实际问题而进行的方法研究， 包括需要非标准方法的分析，替代统计方法的比较，以及 使用与研究项目相关的存档公共数据库进行发现研究。

CORE A ABSTRACT The Administrative component of Core A will provide comprehensive and cohesive support in administrative, fiscal and programmatic aspects of the Program Project. It will also interface with the University of Pennsylvania, Dana Farber Cancer Institute, Fox Chase Cancer Center and the National Cancer Institute (NCI). The Administrative component, in geographical proximity to the scientific core facilities and the laboratories of the project leaders at Penn, will serve many organizational and fiscal functions. These include generation and analysis of monthly budget reports, interfacing with the medical school's research services, coordinating clinical/translational programs, and completing NCI requirements. In addition, the administrative component will continue to coordinate monthly meetings with the project and core facilities leaders; weekly core facilities' meetings; regular research seminars/journal clubs/laboratory meetings; maintain a library, newsletter and website; and promote the program project within the university and medical school (especially as it relates to the internal advisory board-IAB), as well as regionally and nationally. Importantly, the Core will organize the annual conference/retreat in conjunction with the review by the external advisory board (EAB). All IAB and EAB reports will be organized by the Core that will be shared with the Dean (Dr. Larry Jameson), Abramson Cancer Center Director (Dr. Chi Dang), DFCI (Dr. Griffin) and the NCI. As additional measures, the Administrative component will organize workshops in grant writing, manuscript writing, and career development for students, postdoctoral fellows and junior faculty in the Program Project. It will continue to expand the human tissue banking efforts of the Molecular Pathology/Imaging Core (MPIC) and Molecular Biology Core (MBC), promote the databases generated by the Projects and Cores, ensure appropriate the new genomics bioinformatics support through the Molecular Biology Core and integrate the Biostatistics component. There has been establishment of close communication, interaction and synergistic collaborations with Project 3 based at DFCI via direct bidirectional visits (by Project Leaders as well as lab personnel, the latter from DFCI for instruction in the MPIC and MBC), monthly P01 meetings (using current capture and video technology), weekly conference calls, and The Administrative component will advance the innovative and far- reaching goals articulated and envisioned by the Program Project. In aggregate, the administrative component will enhance the intellectual, scientific, structural and fiscal components of the Program Project. Individually and together, Dr. Rustgi and Ms. Hay have vast experience in administration and ensuring thematic integration between the Projects and Cores. The Biostatistics subcomponent will be led by Dr. Gimotty, Associate Director of Core A, who has vast cancer biostatistical experience and joint publications as evidence of the rich synergistic interactions and collaborations.Dr. Gimotty will provide her expertise and experience in cancer biostatistics in the following areas: a) Design of experimental and clinical studies. b) Statistical modeling and Statistical analysis to evaluate each project's research hypotheses. c) Interpretation of research data and collaboration with investigators to make scientifically and statistically appropriate statements, and to assist in the preparation of scientific abstracts, presentations, and manuscripts. d) Methodological investigations to solve practical problems that arise including analyses requiring non-standard methods, comparison of alternative statistical methods, and conduct of discovery studies using archived public databases relevant to the research projects.