Elucidating the chemical biology of the druggable targets in enteric pathogens C. jejuni & E. coli

阐明肠道病原体空肠弯曲菌药物靶标的化学生物学

• 批准号: 10892592
• 负责人: M. Ashfaqul Alam
• 金额: $ 23.54万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10892592
• 关键词: Antibiotic Resistance; Biology; Campylobacter jejuni; Centers of Research Excellence; Chemicals; Escherichia coli; Intervention; Pharmacologic Substance; Research; druggable target; enteric infection; enteric pathogen; gut inflammation; gut microbiota; human pathogen; innovation; microbial; small molecule; therapy development

This proposal’s objective is to elucidate the chemical biology of microbial metabolites and small molecules to specifically target intestinal pathogens, which cause intestinal infection & inflammation. The findings will facilitate the development of intervention strategies to specifically control the emergence and spread of antibiotic resistance in this significant human pathogen without altering the entire gut microbiota.

该提案的目的是阐明微生物代谢物和小分子的化学生物学 专门针对引起肠道感染和炎症的肠道病原体。研究结果将 促进制定干预策略，专门控制疾病的出现和传播 在不改变整个肠道微生物群的情况下，消除这种重要的人类病原体的抗生素耐药性。