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Elucidating the chemical biology of the druggable targets in enteric pathogens C. jejuni & E. coli

Elucidating the chemical biology of the druggable targets in enteric pathogens C. jejuni & E. coli
阐明肠道病原体空肠弯曲菌药物靶标的化学生物学
批准号:
10892592
负责人:
M. Ashfaqul Alam
金额:
$23.54万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-02-01 至 2025-01-31

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中文摘要
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英文摘要
This proposal’s objective is to elucidate the chemical biology of microbial metabolites and small molecules to specifically target intestinal pathogens, which cause intestinal infection & inflammation. The findings will facilitate the development of intervention strategies to specifically control the emergence and spread of antibiotic resistance in this significant human pathogen without altering the entire gut microbiota.
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会议论文
Impact of dysbiotic and symbiotic catabolism of luminal amino acids on intestinal epithelial barrier function and inflammation
  • 批准号:
    10912096
  • 项目类别:
  • 资助金额:
    $37.51万
  • 财政年份:
    2023
  • 负责人:
    M. Ashfaqul Alam
  • 依托单位:
Microbially generated protons mediate interkingdom host-microbiome cross-talk and maintain intestinal homeostasis via reciprocal functions of two proton-sensing GPCRs
  • 批准号:
    10444190
  • 项目类别:
  • 资助金额:
    $8.42万
  • 财政年份:
    2017
  • 负责人:
    M. Ashfaqul Alam
  • 依托单位:
Microbially generated protons mediate interkingdom host-microbiome cross-talk and maintain intestinal homeostasis via reciprocal functions of two proton-sensing GPCRs
  • 批准号:
    9371648
  • 项目类别:
  • 资助金额:
    $10.74万
  • 财政年份:
    2017
  • 负责人:
    M. Ashfaqul Alam
  • 依托单位:
Microbially generated protons mediate interkingdom host-microbiome cross-talk and maintain intestinal homeostasis via reciprocal functions of two proton-sensing GPCRs
  • 批准号:
    9751845
  • 项目类别:
  • 资助金额:
    $4.26万
  • 财政年份:
    2017
  • 负责人:
    M. Ashfaqul Alam
  • 依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 项目类别:
    专项基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2010
  • 负责人:
    贺萍
  • 依托单位: