ACHIEVE GreatER: Addressing Cardiometabolic Health Inequities by Early PreVEntion in the Great LakEs Region

实现更大目标：通过早期预防解决五大湖地区心脏代谢健康不平等问题

• 批准号: 10891820
• 负责人: Phillip David Levy
• 金额: $ 100万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891820
• 关键词: Accounting; Address; Adult; Air; Air Pollutants; Air Pollution; Area; Black American; Black Populations; Black race; Cardiometabolic Disease; Cardiovascular Diseases; Cessation of life; Characteristics; Chronic; Cities; Clinical; Collaborations; Communities; Community Health Aides; Community Outreach; Coronary heart disease; Data Collection; Development; Disparity; Electronic Health Record; Ensure; Environmental Impact; Environmental Risk Factor; Exposure to; Face; Foundations; Future; Goals; Health Services Accessibility; Heart failure; Home; Hospitalization; Hypertension; Incidence; Inequality; Institution; Interruption; Intervention; Life; Life Style; Longevity; Methods; Michigan; Minority Groups; Mission; Morbidity - disease rate; National Institute on Minority Health and Health Disparities; Ohio; Outcome; Pathogenesis; Patients; Persons; Pharmacists; Play; Policy Maker; Population; Positioning Attribute; Poverty Areas; Practical Robust Implementation and Sustainability Model; Prevention; Prevention strategy; Prognosis; Public Health; Race; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Reduce health disparities; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Scientist; Social Behavior; Source; Statistical Data Interpretation; System; Testing; Therapeutic Intervention; Training; Universities; University Hospitals; Vision; air cleaner; black patient; built environment; cardiometabolic risk; cardiometabolism; career; cohort; collaborative care; combat; community engagement; comorbidity; data management; density; disease disparity; experience; fine particles; health disparity; health inequalities; implementation intervention; improved; mortality; novel; outcome disparities; outreach; patient subsets; portability; prevent; programs; racial disparity; racial health disparity; racism; remediation; social health determinants; social vulnerability; urban dwelling

PROJECT ABSTRACT The overall goal of the ACHIEVE GREATER center is to reduce cardiometabolic health disparities and lifespan inequality among Black adults living in Detroit MI and Cleveland OH. Our center seeks to address the spectrum of cardiometabolic risk, from uncomplicated mild high blood pressure (BP) to more severe forms of hypertension with comorbidities, in order to develop multiple prevention strategies for disparities across the life span. In this context, we propose to directly build upon this foundation in a logical extension to a new project aiming to address racial disparities in symptomatic (Stage C) HF. This is vitally important because HF is the most common final manifestation of cardiometabolic diseases in the U.S., accounting for nearly 400,000 deaths and 900,000 hospitalizations per year and serious health disparities persist whereby HF-related morbidity and mortality are greater in Black populations for a number of reasons yet to be fully understood. While the distribution of multiple negative social determinants of health (SDoH) certainly plays a key role, growing evidence further implicates an outsized adverse impact from environmental factors among urban dwelling populations. In this regard, a number of studies show that air pollutants adversely impact HF and its prognosis. - with roughly double the relative impact in Black patients. Moreover, urban centers with a high proportion of minority population also tend to have worse air quality. Indeed, Detroit residents, 80% of whom self-identify as Black, face the highest PM2.5 concentrations in Michigan (97th percentile for the U.S.). As such, we hypothesize that air pollution is an environmental source of racial health disparities and specifically significant contributor to poor outcomes among HF patients in Detroit. To combat this problem, we propose to test an emerging therapeutic intervention, the portable air cleaners (PAC), that we hypothesize will reduce personal-level exposure to PM2.5 resulting in improved clinical outcomes for recently hospitalized HF patients and that this could mitigate racial disparities in HF clinical outcomes. This novel intervention is both practical and scalable, and thus has the potential to revolutionize the treatment of HF and reduce widespread racial disparities.

项目摘要

项目成果

Impact of low/no-charge coronary artery calcium scoring on statin eligibility and outcomes in women: The CLARIFY study.

• DOI: 10.1016/j.ajpc.2022.100392
• 发表时间: 2022-12
• 期刊: AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
• 影响因子: 4.1
• 作者: Al-Kindi, Sadeer;Tashtish, Nour;Rashid, Imran;Sullivan, Claire;Neeland, Ian J;Robinson, Monique;Gross, Ewa M;Shaw, Leslee;Cainzos-Achirica, Miguel;Nasir, Khurram;Kreatsoulas, Catherine;Gilkeson, Robert;Simon, Daniel I;Rajagopalan, Sanjay
• 通讯作者: Rajagopalan, Sanjay

Community Health Workers as Key Allies in the Global Battle Against Hypertension: Current Roles and Future Possibilities.

社区卫生工作者作为全球抗击高血压的关键盟友：当前的角色和未来的可能性。

• DOI: 10.1161/circoutcomes.123.009900
• 发表时间: 2023
• 期刊: Circulation. Cardiovascular quality and outcomes
• 作者: Brook,RobertD;Levy,PhillipD;Brook,AlecJ;Opara,IjeomaN
• 通讯作者: Opara,IjeomaN

Racial Differences in Quality of Life in Patients With Heart Failure Treated With Sodium-Glucose Cotransporter 2 Inhibitors: A Patient-Level Meta-Analysis of the CHIEF-HF, DEFINE-HF, and PRESERVED-HF Trials.

接受钠-葡萄糖协同转运蛋白 2 抑制剂治疗的心力衰竭患者生活质量的种族差异：CHIEF-HF、DEFINE-HF 和 PRESERVED-HF 试验的患者水平荟萃分析。

• DOI: 10.1161/circulationaha.122.063263
• 发表时间: 2023
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Gupta,Kashvi;Spertus,JohnA;Birmingham,Mary;Gosch,KenseyL;Husain,Mansoor;Kitzman,DalaneW;Pitt,Bertram;Shah,SanjivJ;Januzzi,JamesL;Lingvay,Ildiko;Butler,Javed;Kosiborod,Mikhail;Lanfear,DavidE
• 通讯作者: Lanfear,DavidE

Treating Hypertension in Patients With Orthostatic Hypotension: Benefits vs Harms in the Era of Aggressive Blood Pressure Lowering.

治疗直立性低血压患者的高血压：积极降压时代的利与弊。

• DOI: 10.1001/jama.2023.19096
• 发表时间: 2023
• 期刊: JAMA
• 作者: Byrd,JamesBrian;Bisognano,JohnD;Brook,RobertD
• 通讯作者: Brook,RobertD

Access to Mobile Health Interventions Among Patients Hospitalized With Heart Failure: Insights Into the Digital Divide From the CONNECT-HF mHealth Substudy.

因心力衰竭住院的患者获得移动健康干预措施：从 CONNECT-HF mHealth 子研究中洞察数字鸿沟。

• DOI: 10.1161/circheartfailure.123.011140
• 发表时间: 2024
• 期刊: Circulation. Heart failure
• 作者: Diamond,JamieE;Kaltenbach,LisaA;Granger,BradiB;Fonarow,GreggC;Al-Khalidi,HusseinR;Albert,NancyM;Butler,Javed;Allen,LarryA;Lanfear,DavidE;Thibodeau,JenniferT;Granger,ChristopherB;Hernandez,AdrianF;Ariely,Dan;DeVore,Ada
• 通讯作者: DeVore,Ada