Detroit Cardiovascular Training Program

项目摘要 心血管疾病是美国和世界范围内死亡的主要原因。 了解心脏和循环的生物学、生理学和病理学是 加强治疗和预防。韦恩州立大学在提供 在心血管科学方面的广泛培训，在该地区的研究教育中发挥了重要作用。 这项提议是2014年启动的博士前培训项目的首次竞争性续签。我们会 在教育新一代科学家方面继续开展多学科协作培训工作 世卫组织将致力于心血管研究，以改善医疗保健并为经济发展做出贡献 通过可转化为医疗实践的创新实现增长。 为了提供严格的正式研究培训，我们的计划重点是支持博士前毕业生 学生们。基于韦恩州立大学4所学院的19名培训教师组成的团队 和心血管生物学和疾病方面的补充科学专门知识 底特律心血管培训计划强调为初级医生做准备 在心血管健康和疾病的分子机制方面有很强背景的科学家使用 科学调查的综合和转换方法。这项延续提案计划 支持6个博士前培训岗位。受训人员将从以下高素质人才中挑选出来 候选人，包括代表不足的少数族裔，他们可能来自几个机构项目，如 作为NIH最大化学生多样性倡议(IMSD)计划，该计划由 生理学。 我们的培训人员有强大的外部资助的研究计划，优秀的培训生产力， 以及多个联合研究和培训合作。这种广泛和协作的研究和学习 环境使我们能够提供心血管科学方面的多学科培训 在心肌等领域的教学课程和有指导的实验室研究相结合 收缩能力、心肌病、心力衰竭、心肌代谢、高血压、血管生物学和 心血管调节和适应。培训还包括全面指导 负责任地研究和探索不同的职业发展以及写作和 有效出版物、竞争性奖学金和研究资助申请的陈述技巧。 培训方案的运作将由一个咨询委员会监督，并与 外部顾问。特别的机构承诺，包括专门的财政支持，将 继续支持我们的计划，包括为进入多个国家的博士生提供全额奖学金支持 参加T32培训之前的部门计划。生理系办公室将吸收 这一大学范围内的培训计划的人事和会计管理费用。

Project Summary Cardiovascular disease is a leading cause of mortality in the United States and worldwide. Understanding the biology, physiology and pathology of the heart and circulation is the foundation for improving treatment and prevention. Wayne State University has outstanding track records in providing extensive training in cardiovascular sciences, contributing a major role in research education in the region. This proposal is the first competitive renew of a predoctoral training program launched in 2014. We shall continue multidisciplinary and collaborative training effort in the education of a new generation of scientists who will pursue a career in cardiovascular research to improve healthcare and contribute to economic growth by innovations that can translate into medical practice. To provide rigorous formal research training, our program focuses on supporting predoctoral graduate students. Based on a team of 19 training faculty in 4 colleges at Wayne State University with broad and complementary scientific expertise in cardiovascular biology and diseases under continued directorship of Dr. J.-P. Jin, the Detroit Cardiovascular Training Program emphasizes preparing junior scientists with strong backgrounds in molecular mechanisms of cardiovascular health and diseases using integrative and translational approaches to scientific investigation. This continuation proposal plans to support 6 pre-doctoral training positions. Trainees will be selected from a high-quality pool of candidates, including under-represented minorities who may come from several institutional programs such as the NIH Initiative for Maximizing Student Diversity (IMSD) program operated via the Department of Physiology. Our training faculty have strong externally funded research programs, excellent training productivity, and multiple joint research and training collaborations. This broad and collaborative research and learning environment enables us to provide multidisciplinary training in cardiovascular science through a combination of didactic courses and mentored laboratory research in areas such as cardiac muscle contractility, cardiomyopathy, heart failure, myocardial metabolism, hypertension, vascular biology, and cardiovascular regulation and adaptation. The training also includes comprehensive instruction in the responsible conduct of research and exploration of diverse career development as well as writing and presentation skills for effective publications and competitive fellowship and research grant applications. Operation of the training program will be monitored by an Advisory Committee and in consultation with external advisors. Exceptional institutional commitments including dedicated financial support will continue to support our program, including full scholarship support for entering PhD students in multiple departmental programs prior to joining the T32 training. The Department of Physiology office will absorb the personnel and accounting management cost of this university-wide training program.