Detroit Cardiovascular Training Program

底特律心血管培训计划

• 批准号: 10597670
• 负责人: Phillip David Levy
• 金额: $ 10.72万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597670
• 关键词: Cardiovascular system; Training Programs

Project Summary Cardiovascular disease is a leading cause of mortality in the United States and worldwide. Understanding the biology, physiology and pathology of the heart and circulation is the foundation for improving treatment and prevention. Wayne State University has outstanding track records in providing extensive training in cardiovascular sciences, contributing a major role in research education in the region. This proposal is the first competitive renew of a predoctoral training program launched in 2014. We shall continue multidisciplinary and collaborative training effort in the education of a new generation of scientists who will pursue a career in cardiovascular research to improve healthcare and contribute to economic growth by innovations that can translate into medical practice. To provide rigorous formal research training, our program focuses on supporting predoctoral graduate students. Based on a team of 19 training faculty in 4 colleges at Wayne State University with broad and complementary scientific expertise in cardiovascular biology and diseases under continued directorship of Dr. J.-P. Jin, the Detroit Cardiovascular Training Program emphasizes preparing junior scientists with strong backgrounds in molecular mechanisms of cardiovascular health and diseases using integrative and translational approaches to scientific investigation. This continuation proposal plans to support 6 pre-doctoral training positions. Trainees will be selected from a high-quality pool of candidates, including under-represented minorities who may come from several institutional programs such as the NIH Initiative for Maximizing Student Diversity (IMSD) program operated via the Department of Physiology. Our training faculty have strong externally funded research programs, excellent training productivity, and multiple joint research and training collaborations. This broad and collaborative research and learning environment enables us to provide multidisciplinary training in cardiovascular science through a combination of didactic courses and mentored laboratory research in areas such as cardiac muscle contractility, cardiomyopathy, heart failure, myocardial metabolism, hypertension, vascular biology, and cardiovascular regulation and adaptation. The training also includes comprehensive instruction in the responsible conduct of research and exploration of diverse career development as well as writing and presentation skills for effective publications and competitive fellowship and research grant applications. Operation of the training program will be monitored by an Advisory Committee and in consultation with external advisors. Exceptional institutional commitments including dedicated financial support will continue to support our program, including full scholarship support for entering PhD students in multiple departmental programs prior to joining the T32 training. The Department of Physiology office will absorb the personnel and accounting management cost of this university-wide training program.

项目摘要 心血管疾病是美国和世界范围内死亡的主要原因。 了解心脏和循环的生物学、生理学和病理学是 改善治疗和预防。韦恩州立大学在提供 心血管科学方面的广泛培训，在该地区的研究教育中发挥了重要作用。 该提案是2014年启动的博士前培训计划的第一次竞争性更新。我们将 继续开展多学科合作培训工作，培养新一代科学家 谁将追求心血管研究的职业生涯，以改善医疗保健和促进经济发展， 通过可以转化为医疗实践的创新来实现增长。 为了提供严格的正式研究培训，我们的计划侧重于支持博士前研究生 学生基于韦恩州立大学4所学院的19名培训教师组成的团队， 心血管生物学和疾病方面的科学知识和互补性， J博士的董事职位- P. Jin，底特律心血管训练计划强调准备初级 科学家在心血管健康和疾病的分子机制方面有很强的背景， 科学研究的综合和转化方法。这项延续提案计划 支持6个博士前培养岗位。学员将从高质量的人才库中挑选， 候选人，包括代表性不足的少数民族，他们可能来自几个机构， 作为NIH最大化学生多样性倡议（IMSD）计划，该计划通过美国卫生部（Department of Health）运作， Physiology. 我们的培训教师拥有强大的外部资助的研究项目，出色的培训生产力， 以及多项联合研究和培训合作。这种广泛的合作研究和学习 环境使我们能够提供多学科的培训，在心血管科学通过一个 结合教学课程和指导的实验室研究领域，如心肌 收缩性、心肌病、心力衰竭、心肌代谢、高血压、血管生物学，以及 心血管调节和适应。培训还包括全面的教学， 负责任地进行研究和探索多样化的职业发展以及写作和 有效出版物和有竞争力的奖学金和研究补助金申请的演讲技巧。 培训方案的运作将由咨询委员会监督，并与 外部顾问。包括专项财政支助在内的特殊体制承诺将 继续支持我们的计划，包括全额奖学金支持进入博士生在多个 在参加T32培训之前参加部门计划。生理学系办公室将吸收 人事和会计管理费用，这所大学范围内的培训计划。

项目成果

The effects of genetic background on exercise performance in Drosophila.

• DOI: 10.1080/19336934.2020.1835329
• 发表时间: 2020-03
• 期刊: Fly
• 影响因子: 1.2
• 作者: Damschroder D;Richardson K;Cobb T;Wessells R
• 通讯作者: Wessells R

Fructose plus High-Salt Diet in Early Life Results in Salt-Sensitive Cardiovascular Changes in Mature Male Sprague Dawley Rats.

• DOI: 10.3390/nu13093129
• 发表时间: 2021-09-08
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Levanovich PE;Chung CS;Komnenov D;Rossi NF
• 通讯作者: Rossi NF

Effect of N-Terminal Extension of Cardiac Troponin I on the Ca(2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils.

心脏肌钙蛋白I的N末端扩展对肌球蛋白II在天然心脏肌纤维中的ATP结合和ADP解离的Ca（2+）调节。

• DOI: 10.1021/acs.biochem.5b01059
• 发表时间: 2016-03-29
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Gunther LK;Feng HZ;Wei H;Raupp J;Jin JP;Sakamoto T
• 通讯作者: Sakamoto T

Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1".

铁和锌与酵母 Fe-S 簇支架组装蛋白“Isu1”结合的独特作用。

• DOI: 10.1039/c9mt00172g
• 发表时间: 2019
• 期刊: Metallomics : integrated biometal science
• 作者: Lewis,BrianneE;Mason,Zachary;Rodrigues,AndriaV;Nuth,Manunya;Dizin,Eric;Cowan,JA;Stemmler,TimothyL
• 通讯作者: Stemmler,TimothyL

Does Vitamin D Provide Added Benefit to Antihypertensive Therapy in Reducing Left Ventricular Hypertrophy Determined by Cardiac Magnetic Resonance?

维生素 D 是否可以为抗高血压治疗提供额外的益处，以减少心脏磁共振确定的左心室肥厚？

• DOI: 10.1093/ajh/hpac096
• 发表时间: 2023
• 期刊: American journal of hypertension
• 影响因子: 3.2
• 作者: Levy,PhillipD;Twiner,MichaelJ;Brody,AaronM;Dawood,Rachelle;Reed,Brian;Mango,LynnMarie;Gowland,Laura;Grandits,Greg;Svendsen,Kenneth;Haacke,EwartMark;Li,Tao;Zhang,Liying;McNaughton,CandaceD;Flack,JohnM
• 通讯作者: Flack,JohnM