Combination Therapy of Home-based Trans-cranial Direct Current Stimulation and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms in Older Adults with Knee Osteoarthritis
家庭经颅直流电刺激和正念冥想联合疗法对老年膝骨关节炎患者临床疼痛和症状的自我管理
基本信息
- 批准号:10896624
- 负责人:
- 金额:$ 50.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-14 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAdverse eventAffectAreaBrainCategoriesClient satisfactionClinicClinicalClinical TrialsCombined Modality TherapyDegenerative polyarthritisDevicesDouble-Blind MethodElderlyEquipment and supply inventoriesFutureGoalsHealth ExpendituresHomeInterventionInvestigationJointsKneeKnee OsteoarthritisMediatorMeditationModalityMotor CortexNeuronal PlasticityNumeric Rating ScalePainPain managementParticipantPeripheralPersonsPharmaceutical PreparationsPhasePrediction of Response to TherapyPublic HealthQuality of lifeQuestionnairesRandomizedResearchRiskSecureSelf AdministrationSelf ManagementSiteSomatosensory CortexSymptomsSystemTechnologyTestingTimeUnited StatesUnited States Food and Drug AdministrationVideoconferencingWestern Ontario and McMaster Universities Arthritis Indexarmcentral painchronic musculoskeletal painclinical careclinical paincomorbidityconditioned pain modulationdesigndisabilityevidence based guidelinesexperiencefrontal lobefunctional near infrared spectroscopyhemodynamicsimprovedindexinginnovationinsightinterestmindfulnessosteoarthritis painpain processingpain reductionpain self-managementpain sensitivitypharmacologicprescription pain relieverpsychologicrandomized, clinical trialsreal time monitoringresponsesatisfactionside effectspectroscopic imagingsuccesssymptom managementtooltranscranial direct current stimulationtreatment effect
项目摘要
ABSTRACT
The long-term goal of this project is to improve clinical pain and symptoms for older adults with knee
osteoarthritis (OA) using home-based nonpharmacological approaches. Knee OA is one of the most common
pain conditions among people over 45 years old, and the management of OA pain is challenging because
existing pharmacological approaches often produce significant adverse events, and the treatment benefits may
decrease over time. Also, knee OA pain is characterized by increased pain-related brain activation, possibly
explaining the limited success of existing peripherally based treatments that target the pain locally in the area
of the knee. Therefore, innovative nonpharmacological interventions targeting pain-related brain function are
needed. Two nonpharmacological pain treatments, transcranial direct current stimulation (tDCS) and
mindfulness-based meditation (MBM), have been shown to improve pain-related brain function in older adults
with knee OA. The rationale for the proposed research is that because tDCS promotes neuroplasticity, it may
potentiate the effect of MBM, which also stimulates adaptive changes in the brain. However, no investigations
to date have examined whether remotely supervised tDCS paired with MBM at home can enhance pain-related
brain function and reduce OA-related clinical pain and symptoms. Home-based interventions are critical
because older adults with knee OA have limited mobility, and recent technological advances have created the
potential for home interventions with real-time monitoring through a secure videoconferencing platform. The
central hypothesis is that remotely supervised tDCS paired with MBM at home will decrease clinical pain and
OA-related clinical symptoms, improve physiopsychological pain processing, and increase participant
satisfaction with treatment. This hypothesis will be tested by pursuing the following specific aims: determine the
effects of active tDCS paired with active MBM on clinical pain and OA-related clinical symptoms (specific aim
1); determine the effects of active tDCS paired with active MBM on physiopsychological pain processing
(specific aim 2); and determine the effects of active tDCS paired with active MBM on participant satisfaction
with treatment (specific aim 3). The proposed study will directly investigate the effects of remotely supervised
tDCS paired with MBM at home in 200 older adults with symptomatic knee OA using a double-blind,
randomized, sham-controlled, phase II parallel group (1:1:1:1 for four groups defined by 2x2 factorial design)
design. The proposed research is significant because it is expected to provide valuable insight into an exciting
new modality of nonpharmacological pain self-management that is extremely easy, safe, and noninvasive with
minimal side effects.
摘要
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study.
- DOI:10.1016/j.brs.2022.06.003
- 发表时间:2022-07
- 期刊:
- 影响因子:7.7
- 作者:Martorella, Geraldine;Mathis, Kenneth;Miao, Hongyu;Wang, Duo;Park, Lindsey;Ahn, Hyochol
- 通讯作者:Ahn, Hyochol
Feasibility, Acceptability, and Efficacy of Home-Based Transcranial Direct Current Stimulation on Pain in Older Adults with Alzheimer's Disease and Related Dementias: A Randomized Sham-Controlled Pilot Clinical Trial.
- DOI:10.3390/jcm12020401
- 发表时间:2023-01-04
- 期刊:
- 影响因子:3.9
- 作者:Martorella, Geraldine;Miao, Hongyu;Wang, Duo;Park, Lindsey;Mathis, Kenneth;Park, JuYoung;Sheffler, Julia;Granville, Lisa;Teixeira, Antonio L.;Schulz, Paul E.;Ahn, Hyochol
- 通讯作者:Ahn, Hyochol
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Hyochol Ahn其他文献
Hyochol Ahn的其他文献
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{{ truncateString('Hyochol Ahn', 18)}}的其他基金
Pain-related Brain Mechanisms for Pain Catastrophizing Behavior in Response to Home-based Mindfulness-based Meditation Paired with Transcranial Direct Current Stimulation
家庭正念冥想与经颅直流电刺激对疼痛灾难性行为的疼痛相关大脑机制
- 批准号:
10665161 - 财政年份:2022
- 资助金额:
$ 50.79万 - 项目类别:
Combination Therapy of Home-based Trans-cranial Direct Current Stimulation and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms in Older Adults with Knee Osteoarthritis
家庭经颅直流电刺激和正念冥想联合疗法对老年膝骨关节炎患者临床疼痛和症状的自我管理
- 批准号:
10553423 - 财政年份:2020
- 资助金额:
$ 50.79万 - 项目类别:
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