SUBSTANCE USE AMONG YOUNG ADULT CHILDREN OF ALCOHOLICS

拟议的项目扩展了我们正在进行的物质纵向研究 在酗酒者(COA)的儿童中使用，直到成年。整体而言 目标仍然是确定COA对物质使用的风险程度 和滥用，并确定潜在的调解机制。这些 发病机制对了解其发病机制具有重要的理论意义。 药物滥用，以及制定预防措施的实际重要性 干预措施。青壮年是特别有趣的，因为它 使用和滥用药物的比率很高。因此，我们的目标是研究 父母酗酒对青少年物质使用和滥用的影响 结果，以及从青春期到青春期的使用轨迹。 我们研究了这些影响背后的心理社会机制，以及 父母酗酒和青少年物质使用对老年人的影响 进入青壮年的重要发育转变。 为了实现这些目标，我们建议对我们的COA和控制进行后续行动 18-25岁的受试者、他们的父母和同龄人告密者。 我们还建议包括400名受试者的完全亲生兄弟姐妹。 他也将是18-25岁。样本是从社区中抽取的，而不是 治疗环境，包括酗酒的母亲和父亲，以及 “活跃”和“缓解”的酗酒者。父母酗酒及其相关因素 精神病理学是直接确定的，而不是依赖于后代 报告情况。从受试者平均年龄为12.7岁开始，他们和他们的 家长们每年接受3次计算机辅助访谈。这些多个 记者的数据被用来(并将被)用来将响应的影响降到最低 偏见。 在后续工作中，将与 年轻人、他们的兄弟姐妹和他们的父母，以及电话采访 将与同行告密者一起进行。年轻人的结果将是 评估包括药物使用/滥用，其他精神病理学，阳性 结果，以及解决适合年龄的发展任务。 假设的中介变量源自物质理论 使用和虐待，包括父母/同伴社交模式、压力和 负性情绪调节模型、气质模型和模型 强调对物质使用的认知。 数据分析策略包括分层线性建模以评估 父母酗酒和家庭环境变量对青少年的影响 成人药物使用和滥用结果，以及纵向潜伏性增长 用曲线模型评估父母酗酒和心理社会的影响 青春期至青春期药物使用生长曲线的危险因素 成人期。这些发现将对预防具有特别重要的意义 因为他们关注的是高危人群，并追踪 从前体物质的使用到临床的发展 重要的终点。

The proposed project extends our ongoing longitudinal study of substance use among children of alcoholics (COAs) into young adulthood. The overall goal continues to be determining the extent of COA risk for substance use and abuse and identifying mediating mechanisms underlying this risk. These mechanisms are of theoretical importance for understanding the etiology of substance abuse, and practical importance for designing preventive interventions. Young adulthood is of particular interest because of its high rates of substance use and abuse. Accordingly, we aim to examine the effects of parent alcoholism on young adult substance use and abuse outcomes, and on trajectories of use from adolescence to young adulthood. We examine the psychosocial mechanisms underlying these effects and the consequences of parent alcoholism and adolescent substance use for the important developmental transition to young adulthood. To achieve these aims, we propose a follow-up of our COA and control subjects who will be 18-25 years old, their parents, and peer informants. We also propose to include 400 full biological siblings of our subjects who will also be 18-25. The sample is drawn from the community rather than treatment settings, and includes alcoholic mothers and fathers, and both "active" and "remitted" alcoholics. Parent alcoholism and associated psychopathology were directly ascertained rather than relying on offspring report. Beginning when subjects averaged 12.7 years of age, they and their parents received 3 annual computer-assisted interviews. These multiple reporter data were (and will be) used to minimize the impact of response biases. At follow-up, computer-assisted interviews will be conducted with the young adults, their siblings, and their parents, and telephone interviews will be conducted with peer informants. Young adult outcomes to be assessed include substance use/abuse, other psychopathology, positive outcomes, and the resolution of age-appropriate developmental tasks. Hypothesized mediating variables are derived from theories of substance use and abuse including parent/peer socialization models, stress and negative affect regulation models, temperament models, and models emphasizing cognitions about substance use. Data analytic strategies include hierarchical linear modeling to assess the impact of parent alcoholism and family climate variables on young adult substance use and abuse outcomes, and longitudinal latent growth curve modeling to assess the impact of parent alcoholism and psychosocial risk factors on growth curves of substance use from adolescence to young adulthood. The findings will be of particular relevance for prevention because they focus on a high-risk group, and track the natural history of substance use from its precursors to the development of clinically important end points.