Substance Use Among Children of Alcoholics

拟议的项目研究物质使用和物质使用的病因、过程和后果。 在高危样本中，从发育角度研究精神障碍。通过这样做，它解决了一个至关重要的问题 物质使用研究中的问题--即，风险传播的病因途径是什么？ 世代繁衍？我们预测儿童在物质使用结果轨迹上的异质性 酗酒者和对照组，确定家族性酒精中毒风险的中介机制，以及地塞胺的出现， 使用多方法前瞻性研究下一代的风险。 为了实现这些目标，我们利用了一种独特的多代高风险样本，该样本跨越了 ‘物质使用开始导致物质使用障碍的发展和成年人的“成熟”，以及对谁的数据 (已收集自三代(G1-G3)。样本包括酗酒的母亲和父亲 他的酗酒和其他精神障碍被直接证实。从青春期(男性=12.7岁)开始，G2和 他们的父母进行了3次年度评估。进一步的随访(增加了完全的生物兄弟姐妹和同龄人)是) 在青春期后期(第四波)和成年初期(第五波)。第五波还增加了基线多方法j [对G3儿童的评估(平均年龄=7.4岁)。 在拟议的后续行动中，将对G2成年人、他们的G3青少年进行计算机辅助访谈] 儿童，以及G3青少年的另一位父母。其他信息者数据(成人同龄人和青少年教师) (与学校记录一起，数据将通过邮寄收集。G3青少年也将完成标准化任务 评估执行和激励性监管流程。短期18个月的纵向设计允许； 根据现有基线数据和新的建议数据分别预测G3青少年药物使用情况。 评估。这些发现对于预防尤其重要，因为他们关注的是高危人群，他们 追踪物质使用的自然历史，从其前体到临床重要的终点，包括 他们研究了风险在三代人之间的传递情况。

The proposed project studies the etiology, course, and consequences of substance use and substance disorders from a developmental perspective in a high risk sample. In so doing, it addresses a centrally importani question in substance use research-namely, what are the etiological pathways by which risk is transmitted across multiple generations? We predict heterogeneity in trajectories of substance use outcomes among children o alcoholics and controls, identify mediating mechanisms underlying familial alcoholism risk, andexamine emergin, risk in the next generation using a multi-method prospective study. To achieve these aims, we capitalize on a unique multigenerational high risk samplethat spans the ages from 'substance use initiation to the developmentof substance use disorders and adult "maturing out," and for whomdata (have already been collected from three generations (G1-G3). The sample includes alcoholicmothers and fathers whose alcoholism and otherdisorderswere directly ascertained. Beginning in adolescence(M=12.7 years), G2s and) their parents had 3 annual assessments.Further follow-ups (addingfull biologicalsiblings andpeerinformants) were) !done in late adolescence (Wave 4) and early adulthood (Wave 5). Wave 5 also added a baseline multimethodj [assessment of the G3 children (mean age=7.4). At the proposed follow-up, computer-assisted interviews will be conducted with G2adults, their G3adolescent] children, and the G3 adolescent's otherparent. Otherinformant data (peers for adults andteachers for adolescents) (along with school records data will be collected by mail. G3 adolescents will also perform standardized tasks assessing executive and motivational regulatory processes. A short-term 18-month longitudinal design allow; respective prediction of G3 adolescent substance use from existing baseline data as well as the newly.proposed assessments. The findings are particularly important for prevention because they focus on a high risk group,they track the natural history of substance use from its precursors to clinically important end points, they include 'Otentially modifiable factors, and they examine the transmission of risk across three generations.