Substance Use Among Children of Alcoholics

拟议的项目研究的病因，过程，和物质使用和物质的后果 从发展的角度来看，在高风险样本中的疾病。这样做，它解决了一个核心的重要问题， 物质使用研究中的一个问题，即风险通过何种病因学途径传播 几代人？我们预测了儿童药物使用结果轨迹的异质性， 酗酒者和对照组，确定家族性酗酒风险的介导机制，以及地塞米松的出现， 使用多方法前瞻性研究的下一代风险。 为了实现这些目标，我们利用了一个独特的多代高风险样本， “物质使用开始发展为物质使用障碍和成人“成熟”， (have已经收集了三个世代（G1-G3）。样本包括酗酒的母亲和父亲 whose谁alcoholism酗酒and otherdisorders其他disorders紊乱were directly直接determined确定.从青春期开始（M=12.7岁），G2和） 他们的父母有3个年度评估。进一步的随访（添加完整的生物学兄弟姐妹和同龄人） !在青春期后期（第4波）和成年早期（第5波）进行。Wave 5还增加了一个基线multimethodj [评估G3儿童（平均年龄=7.4）。 在拟议的后续行动中，将对G2成人、他们的G3青少年进行计算机辅助访谈] 孩子和G3青少年的另一个父母。非信息者数据（成人的同龄人和青少年的教师） （沿着学校记录数据将通过邮件收集。G3青少年也将执行标准化任务 评估执行和激励性监管过程。短期18个月的纵向设计允许; 根据现有的基线数据以及新提出的 评估。这些发现对预防特别重要，因为它们关注的是高风险群体， 跟踪物质使用的自然历史，从其前体到临床重要终点，它们包括 “这些因素可能是可以改变的，他们研究了三代人之间的风险传递。

The proposed project studies the etiology, course, and consequences of substance use and substance disorders from a developmental perspective in a high risk sample. In so doing, it addresses a centrally importani question in substance use research-namely, what are the etiological pathways by which risk is transmitted across multiple generations? We predict heterogeneity in trajectories of substance use outcomes among children o alcoholics and controls, identify mediating mechanisms underlying familial alcoholism risk, andexamine emergin, risk in the next generation using a multi-method prospective study. To achieve these aims, we capitalize on a unique multigenerational high risk samplethat spans the ages from 'substance use initiation to the developmentof substance use disorders and adult "maturing out," and for whomdata (have already been collected from three generations (G1-G3). The sample includes alcoholicmothers and fathers whose alcoholism and otherdisorderswere directly ascertained. Beginning in adolescence(M=12.7 years), G2s and) their parents had 3 annual assessments.Further follow-ups (addingfull biologicalsiblings andpeerinformants) were) !done in late adolescence (Wave 4) and early adulthood (Wave 5). Wave 5 also added a baseline multimethodj [assessment of the G3 children (mean age=7.4). At the proposed follow-up, computer-assisted interviews will be conducted with G2adults, their G3adolescent] children, and the G3 adolescent's otherparent. Otherinformant data (peers for adults andteachers for adolescents) (along with school records data will be collected by mail. G3 adolescents will also perform standardized tasks assessing executive and motivational regulatory processes. A short-term 18-month longitudinal design allow; respective prediction of G3 adolescent substance use from existing baseline data as well as the newly.proposed assessments. The findings are particularly important for prevention because they focus on a high risk group,they track the natural history of substance use from its precursors to clinically important end points, they include 'Otentially modifiable factors, and they examine the transmission of risk across three generations.