课题基金 / 基金详情

P562C, A NOVEL C2 DOMAIN PROTEIN OF LEUKOCYTES

P562C, A NOVEL C2 DOMAIN PROTEIN OF LEUKOCYTES
P562C,一种新型白细胞 C2 结构域蛋白
批准号:
2650067
负责人:
Bernard M Babior
金额:
$19.47万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-09-01 至 1999-08-31

项目摘要

项目成果

Bernard M Babior的其他基金

相似基金

相关文献

中文摘要
翻译
白细胞NADPH氧化酶催化O2的产生
英文摘要
The leukocyte NADPH oxidase catalyzes the production of O2 from oxygen and NADPH. The yeast 2-hybrid system was used to look for proteins the interact with p67, one of the cytosolic subunits of the oxidase. This system identified a B lymphocyte cDNA that encoded a 56 kDa protein containing two Ca++ and lipid-binding C2 domains in its C-terminal half. Rabphilin-3A, a Rab3a-binding protein involved in synaptic vesicle trafficking, has a similar C2 domain structure, suggesting that the new protein, designated p56C2 and characterize it in terms of its location in neutrophils and B lymphocytes, its interactions with other leukocyte proteins and with the cortical cytoskeleton, and its association with lipids. The function of p56C2 will be studied by examining its effect on oxidase activation in the phosphorylation-dependent oxidase activating system, by examining oxidase activation and secretory vesicle fusion in cells depleted of the protein by antisense techniques, and by studying a transgenic mouse deficient in the protein. Particular attention will be paid to the possibility that p56C2 interacts with Rap1A, a small guanine nucleotide-binding protein that copurifies with the membrane- associated subunits of the oxidase. Through these experiments we hope to achieve a deeper understanding of the activation of the O2- forming oxidase of leukocytes, and enzyme important in host defense and in the harmful side effects of inflammation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Function of normal and malignant phagocytes
  • 批准号:
    7042993
  • 项目类别:
  • 资助金额:
    $4.33万
  • 财政年份:
    2004
  • 负责人:
    Bernard M Babior
  • 依托单位:
P56C2, A NOVEL C2 DOMAIN PROTEIN OF LEUKOCYTES
  • 批准号:
    2761192
  • 项目类别:
  • 资助金额:
    $33.39万
  • 财政年份:
    1998
  • 负责人:
    Bernard M Babior
  • 依托单位:
P56C2, A NOVEL C2 DOMAIN PROTEIN OF LEUKOCYTES
  • 批准号:
    6124282
  • 项目类别:
  • 资助金额:
    $34.39万
  • 财政年份:
    1998
  • 负责人:
    Bernard M Babior
  • 依托单位:
P56C2, A NOVEL C2 DOMAIN PROTEIN OF LEUKOCYTES
  • 批准号:
    6328813
  • 项目类别:
  • 资助金额:
    $35.42万
  • 财政年份:
    1998
  • 负责人:
    Bernard M Babior
  • 依托单位:
海外基金