EMF EFFECTS ON MELATONIN AMONG AGING VOLUNTEERS

这是一项响应RFA ES-06-007的小额赠款提案， “工频电磁场的生物效应。”它是被假设的 电磁场可以抑制褪黑激素，并通过 在这一机制中，电磁场可能介导发病率和死亡率。问题 对于褪黑激素水平较低的老年人来说，情况可能尤其严重。 褪黑素防止衰老的假说，例如，与衰老有关的衰老 自由基损伤和癌症，最近收到了耸人听闻的消息 覆盖范围。数百万担心褪黑激素缺乏的美国人可能会 从健康食品店购买标有褪黑素的产品。这个 调查人员提议对卧室内的电磁场进行严格测试 影响每日褪黑激素的排泄。这笔小额赠款将允许 调查人员收集家庭电动势记录结合数据 被收集用于其他关于褪黑激素排泄和就寝时间的项目 光线级别。电动势合成矢量强度与电磁场的相关性 每晚将测定褪黑素排泄量，以确定EMF 可能是褪黑激素产生的重要调节因素。统计 对年龄、性别、光照水平和药物摄入的控制将是 实施。这项研究将确定电磁场是否可能是一种 褪黑素排泄变化的重要来源。结合 随着正在进行的研究，可能通过褪黑素的间接电动势效应 关于发病率和死亡率的问题将得到考虑。

This is a small grant proposal in response to RFA ES-06-007, "Biological effects of power frequency EMF." It has been hypothesized that EMF (electro-magnetic fields) may suppress melatonin, and through this mechanism, EMF might mediate morbidity and mortality. The problem may be particularly severe for elderly people who have low melatonin. The hypothesis that melatonin prevents aging, e.g., aging related to free-radical damage and cancer, has recently received sensational news coverage. Millions of Americans fearful of melatonin deficiency may be buying products from health food stores labeled as melatonin. The investigators propose to critically test whether EMF in the bedroom influences daily melatonin excretion. This small grant will permit the investigators to collect home EMF recordings to combine with data being collected for other projects on melatonin excretion and bedtime light levels. The correlation of EMF resultant vector strength and nightly melatonin excretion will be determine, to establish if EMF could be a substantial regulator of melatonin production. Statistical controls for age, gender, light levels, and drug intake will be implemented. This study will establish whether EMF could be an important source of variance in melatonin excretion. In conjunction with ongoing studies, possible indirect EMF effects through melatonin on morbidity and mortality will be considered.