EMF EFFECTS ON MELATONIN AMONG AGING VOLUNTEERS

电磁场对老年志愿者褪黑激素的影响

• 批准号: 2331608
• 负责人: DANIEL Frederick KRIPKE
• 金额: $ 7.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-15 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2331608
• 关键词: aging; circadian rhythms; clinical research; human middle age (35-64); human mortality; human old age (65+); human subject; magnetic field; melatonin; mood disorders; radiobiology; sleep disorders; urinalysis

This is a small grant proposal in response to RFA ES-06-007, "Biological effects of power frequency EMF." It has been hypothesized that EMF (electro-magnetic fields) may suppress melatonin, and through this mechanism, EMF might mediate morbidity and mortality. The problem may be particularly severe for elderly people who have low melatonin. The hypothesis that melatonin prevents aging, e.g., aging related to free-radical damage and cancer, has recently received sensational news coverage. Millions of Americans fearful of melatonin deficiency may be buying products from health food stores labeled as melatonin. The investigators propose to critically test whether EMF in the bedroom influences daily melatonin excretion. This small grant will permit the investigators to collect home EMF recordings to combine with data being collected for other projects on melatonin excretion and bedtime light levels. The correlation of EMF resultant vector strength and nightly melatonin excretion will be determine, to establish if EMF could be a substantial regulator of melatonin production. Statistical controls for age, gender, light levels, and drug intake will be implemented. This study will establish whether EMF could be an important source of variance in melatonin excretion. In conjunction with ongoing studies, possible indirect EMF effects through melatonin on morbidity and mortality will be considered.

这是响应RFA ES-06-007的小额赠款提案， 电力频率EMF的生物效应。“有人假设 EMF（电磁场）可以抑制褪黑激素，并通过 因此，EMF可能介导发病率和死亡率。问题 对于褪黑激素低的老年人来说可能特别严重。 褪黑激素防止衰老的假设，例如，与衰老有关的 自由基损伤和癌症，最近收到了耸人听闻的消息 覆盖 数百万担心褪黑激素缺乏的美国人可能 从健康食品商店购买标有褪黑激素的产品。 的 研究人员建议严格测试卧室中的电磁场是否 影响每日褪黑激素的分泌。 这笔小额赠款将允许 调查人员收集家庭电磁场记录，以联合收割机与数据相结合 正在收集其他项目的褪黑激素分泌和就寝时间 光水平。 电动势合成矢量强度与 将测定夜间褪黑激素分泌，以确定是否存在EMF 可能是褪黑激素产生的重要调节剂。 统计 年龄、性别、光照水平和药物摄入量的控制将被 切实贯彻 这项研究将确定是否EMF可以是一个 褪黑激素分泌变异的重要来源。 结合 随着正在进行的研究，通过褪黑激素可能的间接EMF效应 发病率和死亡率将被考虑。