BEHAVIORAL/LIGHT EFFECTS ON MENSTRUAL CYCLE REGULATION

描述(改编自申请者摘要)：这是一笔小额赠款 关于测试新的精神/行为治疗方法的提案。上一首 Edmond Dewan和UCSD团队的研究表明，当晚 光可以缩短和调节女性长时间的月经周期 和不规律的月经周期。可能会出现一些月经不规律 从女性如何将自己暴露在光明和 光线暗淡。进一步测试新的夜间照明方法和 技术是必要的，以进一步验证治疗方法和 计时(按月时间和夜间时间)，以延长 剂量/反应测试，并进一步评估舒适性和可靠性 点亮的睡眠面罩。60名受薪女性志愿者，月经周期 将招募35-60天。每一科目都将被前瞻性地跟踪。 对于基线月经周期，然后将随机设置为夜间光照 月经开始后13-17晚进行治疗。治疗 由分层随机分配将由250个通量白光组成 (一种先前证明有效的治疗方法)、25勒克斯、2.5勒克斯或 0.025勒克斯(安慰剂)。在接下来的两个月经周期中，有条件的 将添加交叉治疗。如果受试者回答第一个问题 治疗结束后，将在第二个和第三个治疗周期中重复。 如果受试者在第一个或第二个周期内没有反应， 加大治理力度。如果一个可靠的方法论 可以用夜灯来调节月经周期，这是可以演示的 方法可能导致有价值的方法来辅助行为(节奏) 避孕和不孕不育的新方法。

DESCRIPTION (Adapted from the Applicant's Abstract): This is a small grant proposal to test new methods of psychiatric/behavioral treatment. Previous research by Edmond Dewan and by this UCSD group has suggested that night light can shorten and regularize the menstrual cycles of women with long and irregular menstrual cycles. Some menstrual irregularities may arise from behavioral aberrations in how women expose themselves to bright and dim illumination. Further testing of new night light methods and techniques is necessary to further validate the treatment methods and timing (in terms of both time-of-the-month and time-of-night), to extend dose/response testing, and to further assess the comfort and reliability of lighted sleep masks. Sixty paid female volunteers with menstrual cycles of 35-60 days will be recruited. Each subject will be followed prospectively for a baseline menstrual cycle, and then will be randomized to night light treatment on nights 13-17 after the onset of menstruation. Treatments assigned by stratified randomization will consist of 250 flux white light (a treatment previously demonstrated to be effective), 25 lux, 2.5 lux, or 0.025 lux (a placebo). In the following two menstrual cycles, conditional crossover treatments will be added. If the subject responds to the first treatment, it will be repeated in the second and third treatment cycles. If the subject fails to respond in the first or second cycles, the treatment intensity will be stepped-up. If a reliable methodology of regulating menstrual cycles with night lights can be demonstrated, this approach might lead to valuable methods of assisting behavioral (rhythm) contraception and to new approaches to infertility.