QUANT MOEDELING OF VIS ATTN DEF IN PD PATIENTS

描述(改编自申请者的摘要)：历史、研究 一项研究神经疾病患者群体认知缺陷的研究 与使用数学模型检查的研究分开 然而，这两个领域已经开始融合(例如， Farah，1990；Maddox等人，1995)。基于模型的分析通常更优越 对于传统的特定认知缺陷，以及(C)确定其大小 这些赤字。马多克斯，艾尔。艾尔(1995)利用建模技术 从两个方面考察帕金森病患者的信息整合能力 刺激(称为维度整合，DI)，以及(B)参加 选择性地关注刺激的一个方面，而忽略另一个方面(称为 选择性注意；SA)。我们发现帕金森病患者没有显示出DI缺陷， 但很大一部分帕金森氏症患者确实表现出SA缺陷。这项建议 概述了这项研究的两个扩展。项目1将检查 刺激可分离性和完整性对PD的差异性影响 患者的SA表现。正常受试者的SA表现很强 受刺激可分离性和完整性的影响；SA易于与 可分维，但用整维很难(Maddox，1992)。 Maddox等人。(1995)使用了积分维度，并在 帕金森病患者。在项目1中，受试者将参与两个实验； 一个使用整型维度，另一个使用可拆分维度 尺寸。将应用基于模型的分析来隔离和量化 刺激完整性对帕金森病患者SA表现的影响项目 2将研究内部和外部的不同影响 帕金森病患者的DI表现标准。Maddox等人。(1995)发现 PD患者在无内参照的情况下，其DI能力未受到损害 是必需的。一些人认为，帕金森病患者在执行任务时受到的损害更大 这对注意力的内部控制提出了更高的要求(例如，Brown &Marsden，1988)。受试者将参与两个类似的实验 在项目1中使用，但是需要外部标准，并且 其他不会基于模型的分析将再次用于隔离和 量化内部标准与外部标准对PD患者的影响 DI性能。

DESCRIPTION (Adapted from applicant's abstract): Historically, research that examines cognitive deficits in neurological patient populations has remained separate from research that uses mathematical models to examine "normal cognition. However, these two areas have begun to merge (e.g., Farah, 1990; Maddox, et.al., 1995). Model-based analyses are often superior to traditional specific cognitive deficit, and (c) determine the magnitude of these deficits. Maddox, el. al. (1995) utilized modeling techniques to examine PD patients' ability (a) to integrate information from two aspects of a stimulus (termed dimensional integration, DI), and (b) to attend selectively to one aspect of a stimulus while ignoring the other (termed selective attention; SA). We found that PD patients showed no DI deficits, but a large proportion of PD patients did show SA deficits. This proposal outlines two extensions of this research. Project 1 will examine the differential effects of stimulus separability and integrality on PD patients' SA performance. Normal subjects' SA performance is strongly influenced by stimulus separability and integrality; SA is easy with separable dimension, but is hard with integral dimensions (Maddox, 1992). Maddox et al. (1995) utilized integral dimensions and found SA deficits in PD patients. In Project 1, subjects will participate in two experiments; one that uses integral dimensions, and the other that uses separable dimensions. Model-based analyses will be applied to isolate and quantify the effects of stimulus integrality on PD patients' SA performance. Project 2 will examine the differential effects of an internal vs. external criterion on PD patients' DI performance. Maddox et al. (1995) found that PD patient were not impaired in their DI ability when no internal referent was required. Some have argued that PD patients had more impaired on tasks that place greater demands on the internal control of attention (e.g., Brown & Marsden, 1988). Subjects will participate in two experiments like those used in Project 1, however one will require an external criterion, and the other will not model-based analyses will again be used to isolate and quantify the effects of an internal vs. external criterion on PD patients' DI performance.