PHYSIOLOGICAL RESPONSES TO TONES IN ACUTE PTSD

急性创伤后应激障碍 (PTSD) 对音调的生理反应

• 批准号: 2249688
• 负责人: ARIEH Y SHALEV
• 金额: $ 9.6万
• 依托单位: HADASSAH-HEBREW UNIVERSITY MEDICAL CTR
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2249688
• 关键词: audiometry; autonomic reflex; behavioral habituation /sensitization; diagnosis design /evaluation; electromyography; heart rate; human subject; imagery; mental disorder diagnosis; mental disorders; posttraumatic stress disorder; psychometrics; psychophysiology

The relationship between the physiological reaction to a traumatic event and the subsequent development of post-traumatic stress disorder (PTSD) remains obscure and uninvestigated. This project will attempt to clarify this relationship by extending previous work of the PI's and colleagues' performed in chronic PTSD patients to acutely traumatized subjects. This previous work has demonstrated the presence of elevated, poorly habituating physiological responses to the presentation of loud tone stimuli in subjects with chronic PTSD Pilot data from seventeen acute trauma victims studied according to the methodology proposed herein are highly promising for confirmation of the central hypothesis of the proposed work that the presence of large, poorly habituating autonomic and eyeblink responses to loud tones shortly after a traumatic event will predict the PTSD outcome months later. Subject candidates will be recruited from the population of patients presenting to an Israeli University Hospital Emergency Room who have just experienced psychologically traumatic events that meet the DSM-III-R "A" PTSD criterion. At an initial assessment one week following the index traumatic event, the subject's orbicularis oculi electromyogram (EMG), skin conductance, and heart rate responses to a series of loud tone presentations will be measured. At subsequent assessments performed one and six months following the index event, the subject will be evaluated for the presence of PTSD and other mental disorders by means of the Clinician-Administered PTSD Scale (CAPS) and Structured Interview for DSM- III-R (SCID). The tone procedure will be repeated, and subjects will also undergo a further psychophysiological PTSD assessment using a script- driven imagery procedure. A number of PTSD-related and other psychometric measures will also be obtained. The relationship between physiological responses to the tone presentations at the one-week assessment and the PTSD outcome at the one- and six-month assessments will be evaluated by means of logistic regression. A number of other predictor variables, and potentially confounding variables, will be entered into the analysis for the purpose of calculating the adjusted odds ratio for PTSD.

创伤事件的生理反应之间的关系 以及创伤后应激障碍（PTSD）的后续发展 仍然模糊且未经调查。 该项目将试图澄清 通过扩展 PI 和同事之前的工作来建立这种关系 在慢性 PTSD 患者和急性创伤受试者中进行。 这 之前的工作已经证明存在升高的、较差的 习惯对响亮声音的生理反应 患有慢性创伤后应激障碍 (PTSD) 受试者的刺激 来自 17 名急性创伤后应激障碍 (PTSD) 患者的试点数据 根据本文提出的方法研究的创伤受害者是 对于证实中心假设非常有希望 拟议的工作表明，存在大量的、不太习惯的自主神经和 创伤事件发生后不久对响亮的声音做出眨眼反应 预测几个月后的 PTSD 结果。 受试者候选人将从患者群体中招募 到以色列大学医院急诊室就诊，他们刚刚 经历过符合 DSM-III-R“A”标准的心理创伤事件 创伤后应激障碍标准。 在指数发布一周后进行初步评估 创伤事件，受试者的眼轮匝肌肌电图（EMG）， 皮肤电导和心率对一系列响亮音调的反应 演示文稿将受到衡量。在随后的评估中进行了一项 指数事件发生后六个月，将对主题进行评估 是否存在 PTSD 和其他精神障碍 临床医生管理的 PTSD 量表 (CAPS) 和 DSM 结构化访谈 III-R（SCID）。 将重复音调程序，受试者也会 使用脚本进行进一步的心理生理学 PTSD 评估 驱动图像程序。 许多与 PTSD 相关的和其他心理测量 也将采取措施。 生理反应与音调呈现之间的关系 一周评估以及一周和六个月的 PTSD 结果 评估将通过逻辑回归进行评估。 一个数字 其他预测变量和潜在的混杂变量将 进入分析以计算调整后的 PTSD 的比值比。