Mechanisms of DNA damage-induced oocyte apoptosis and infertility: examination of the role of BH3-only proteins.

我们预防或推迟癌症治疗后绝经的能力，对女性生育能力、健康和生活质量具有重要意义。我们将证明Bcl-2生死基因家族的死亡基因Puma负责在破坏性治疗后杀死女性生殖细胞。当Puma缺失时，足够的高质量生殖细胞能够在破坏性治疗中存活下来，使小鼠能够正常生育。这些获救的生殖细胞的质量将被详细分析。

Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in detail.