课题基金 / 基金详情

Mechanisms of DNA damage-induced oocyte apoptosis and infertility: examination of the role of BH3-only proteins.

Mechanisms of DNA damage-induced oocyte apoptosis and infertility: examination of the role of BH3-only proteins.
DNA 损伤诱导卵母细胞凋亡和不孕的机制:检查 BH3-only 蛋白的作用。
批准号:
nhmrc : 1006460
负责人:
A/Pr Clare Scott
金额:
$33.06万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

A/Pr Clare Scott的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in detail.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Exploring the DNA repair capacity of oocytes
  • 批准号:
    nhmrc : 1100219
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.1万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Clare Scott
  • 依托单位:
Engineering MYCN models of high-grade serous ovarian cancer (HGSC)
Molecular subtype specific therapy in high grade serous ovarian cancer
  • 批准号:
    nhmrc : 1081178
  • 项目类别:
    Project Grants
  • 资助金额:
    $55.49万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Clare Scott
  • 依托单位:
Tailoring targeted therapy to DNA repair-defective High-Grade Serous Ovarian Cancer
国内基金
海外基金
自供能传感阵列同步量化游离DNA与PSA实现前列腺癌的诊断和预后判断
  • 批准号:
    JCZRLH202601177
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
  • 依托单位:
二氢杨梅素通过线粒体代谢重编程抑制DNA同源重组修复逆转口腔癌细胞放疗抵抗的机制研究
  • 批准号:
    2026JJ80500
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    阳帆
  • 依托单位:
乳酸通过ESM1-Akt-MDM2-p53通路调控卵巢癌DNA损伤和抗肿瘤免疫应答的分子机制研究
  • 批准号:
    2026JJ81975
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    肖娇
  • 依托单位:
淫羊藿苷通过TET2介导DNA去甲基化调控Hippo-YAP/TAZ通路逆转绝经后骨质疏松症成血管-成骨耦联失衡的机制研究