Mechanisms of DNA damage-induced oocyte apoptosis and infertility: examination of the role of BH3-only proteins.

DNA 损伤诱导卵母细胞凋亡和不孕的机制：检查 BH3-only 蛋白的作用。

• 批准号: nhmrc : 1006460
• 负责人: A/Pr Clare Scott
• 金额: $ 33.06万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-dna-damage-only-proteins/109181
• 关键词: Mechanisms; DNA; damage; induced; oocyte

Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in detail.

我们预防或推迟癌症治疗后绝经的能力，对女性生育力，健康和生活质量至关重要。我们将证明，Bcl-2家族的死亡基因和死亡基因，Puma，是负责在损伤治疗后杀死女性生殖细胞。当Puma不存在时，足够的高质量生殖细胞能够在破坏性治疗中存活，从而使小鼠具有正常的生育能力。这些获救的生殖细胞的质量将被详细分析。