Exploring the DNA repair capacity of oocytes

探索卵母细胞的DNA修复能力

• 批准号: nhmrc : 1100219
• 负责人: A/Pr Clare Scott
• 金额: $ 51.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-dna-repair-capacity-oocytes/662499
• 关键词: Exploring; DNA; repair; capacity; oocytes

As women age, the quality of their eggs decline and their chance of having a healthy baby plummets. The accumulation of DNA damage within the egg, and the reduced ability to repair this damage, may be one cause of compromised reproductive success in older women. This project will investigate the ability of eggs to repair DNA damage during maternal aging and will explore the importance of DNA repair to fertility and the transmission of high quality genetic material to their offspring.

随着女性年龄的增长，她们的卵子质量下降，生下健康宝宝的机会也会大幅下降。卵子内DNA损伤的积累以及修复这种损伤的能力降低可能是老年女性生殖成功受损的原因之一。该项目将研究卵子在母亲衰老过程中修复DNA损伤的能力，并将探索DNA修复对生育能力的重要性以及高质量遗传物质向后代的传递。