STRUCTURAL DEFECTS CAUSED BY TUMOR DERIVED MUTATIONS IN TUMOR SUPPRESSOR P16

肿瘤抑制因子 P16 的肿瘤衍生突变引起的结构缺陷

• 批准号: 6665881
• 负责人: ZHENG-YU PENG
• 金额: $ 15.75万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665881
• 关键词: biological products; biomedical resource; cardiovascular system; communication behavior; female; human subject; intestines; lipids; male; spectrometry

The goal of this study is to understand how tumor-derived mutations disrupt the structure and function of tumor suppressor p16INK4a and to investigate the possibility of restoring the the function of mutant p16 proteins by stabilization of the native state.

本研究的目的是了解肿瘤源性 突变破坏了肿瘤抑制基因的结构和功能 p16INK4a基因的表达，并探讨其恢复正常表达的可能性。 突变型p16蛋白通过稳定天然状态发挥功能。