PROTEIN METABOLISM IN CHRONIC RENAL FAILURE PATIENTS
慢性肾衰竭患者的蛋白质代谢
基本信息
- 批准号:6665862
- 负责人:
- 金额:$ 15.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-08-01 至 2003-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To study protein metabolism in patients with end-stage renal
disease, we measured leucine kinetics in 8 patients. Study was
performed twice before and once after (period III)( initiation of
maintenance dialysis treatment. Before dialysis, one measurement was
done when the patients are acidotic (period I), and the other during
sodium bicarbonate supplementation when acidosis was corrected (period
II). Sequence of Periods I and II were randomized. Subjects were on
identical constant diet during all three periods. Leucine kinetics
was measured during primed-constant infusion of [1-13C]leucine,
[1-13C]KIC or ( keto-isocaproate and expired breath CO2 enrichment
were directly determined. These values were used to calculate leucine
appearance rates into the plasma leucine pool and into the total body
leucine pool and leucine oxidation rate. The former represents
protein degradation rat; protein synthesis rate was indirectly
estimated by mass balance equation. The h igher leuc ine oxidation
rate without bicarbonate supplementation was not due to higher VCO2 as
total CO2 production rate was not different during the three periods.
Alternatively, higher proportion of endogenously produced CO2 may be
excreted than in the non-acidotic state. Finally, these findings may
represent a real enhancement of amino acid oxidation in the presence
of metabolic acidosis.
目的:研究终末期肾病患者的蛋白质代谢,
疾病,我们测量了8例患者的亮氨酸动力学。 研究
进行了两次之前和一次之后(第三阶段)(开始
维持透析治疗。 透析前,一项测量结果为
当病人酸中毒时(第一阶段),另一个在
纠正酸中毒时补充碳酸氢钠(阶段
II)。 阶段I和II的顺序随机化。 受试者接受
在所有三个时期都是相同的恒定饮食。 亮氨酸动力学
在[1- 13 C]亮氨酸的引发恒定输注期间测量,
[1- 13 C]KIC或(酮-异己酸盐和呼气CO2富集
是直接决定的。 这些值用于计算亮氨酸
进入血浆亮氨酸池和全身的出现率
亮氨酸库和亮氨酸氧化速率。 前者代表
蛋白质降解率、蛋白质合成率
通过质量平衡方程估计。 亮氨酸氧化程度越高
没有碳酸氢盐补充的比率不是由于较高的VCO 2,
总CO2产生率在三个时期没有不同。
可替代地,可以增加更高比例的内源性产生的CO2。
比在非酸中毒状态下排泄。 最后,这些发现可能
代表在存在下氨基酸氧化的真实的增强
代谢性酸中毒
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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VICTORIA S LIM其他文献
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{{ truncateString('VICTORIA S LIM', 18)}}的其他基金
REQUEST TO TAKE BLOOD SAMPLES FROM 20 HEALTHY CONTROL SUBJECTS
要求从 20 名健康对照对象采集血样
- 批准号:
7604886 - 财政年份:2007
- 资助金额:
$ 15.75万 - 项目类别:
LEUCINE TRNOVR RATS W/ NEPHROTIC SYNDROME SUGGEST BODY PROTEIN CONSERVATION
患有肾病综合症的亮氨酸 TRNOVR 大鼠建议保护身体蛋白质
- 批准号:
6665861 - 财政年份:2002
- 资助金额:
$ 15.75万 - 项目类别:
PROTEIN METABOLISM IN CHRONIC RENAL FAILURE PATIENTS
慢性肾衰竭患者的蛋白质代谢
- 批准号:
6486742 - 财政年份:2001
- 资助金额:
$ 15.75万 - 项目类别:
LEUCINE TRNOVR RATS W/ NEPHROTIC SYNDROME SUGGEST BODY PROTEIN CONSERVATION
患有肾病综合征的亮氨酸 TRNOVR 大鼠建议保护身体蛋白质
- 批准号:
6486741 - 财政年份:2001
- 资助金额:
$ 15.75万 - 项目类别:
PROTEIN METABOLISM IN CHRONIC RENAL FAILURE PATIENTS
慢性肾衰竭患者的蛋白质代谢
- 批准号:
6336812 - 财政年份:2000
- 资助金额:
$ 15.75万 - 项目类别:
LEUCINE TRNOVR RATS W/ NEPHROTIC SYNDROME SUGGEST BODY PROTEIN CONSERVATION
患有肾病综合征的亮氨酸 TRNOVR 大鼠建议保护身体蛋白质
- 批准号:
6336811 - 财政年份:2000
- 资助金额:
$ 15.75万 - 项目类别:
EFFECT OF UREMIA AND ACIDOSIS ON INSULIN INDUCED PROTEIN ANABOLISM
尿毒症和酸中毒对胰岛素诱导的蛋白质合成代谢的影响
- 批准号:
6304819 - 财政年份:1999
- 资助金额:
$ 15.75万 - 项目类别:
EFFECT OF UREMIA AND ACIDOSIS ON INSULIN INDUCED PROTEIN ANABOLISM
尿毒症和酸中毒对胰岛素诱导的蛋白质合成代谢的影响
- 批准号:
6114725 - 财政年份:1998
- 资助金额:
$ 15.75万 - 项目类别:
UREMIA, ACIDOSIS & DIALYSIS ON PROTEIN METABOLISM: LONGITUDINAL LEUCINE KINETICS
尿毒症、酸中毒
- 批准号:
6118556 - 财政年份:1998
- 资助金额:
$ 15.75万 - 项目类别:
LEUCINE TURNOVER IN PATS W/ NEPHROTIC SYN: POSSIBLE BODY PROTEIN CONSERVATION
肾病综合征 PATS 中亮氨酸的转化:可能的身体蛋白质保护
- 批准号:
6118555 - 财政年份:1998
- 资助金额:
$ 15.75万 - 项目类别:
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