COLLECTINS AND LUNG DEFENSE
集合素和肺部防御
基本信息
- 批准号:6627298
- 负责人:
- 金额:$ 12.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-01-01 至 2003-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The present application seeks to determine the effect of viral infection
on surfactant homeostasis and the role of surfactant protein-A (SP-A)
in protecting the lung from viral infection. The lung is continually
exposed to inhaled pathogens, yet, remains remarkably free from
infection. SP-A is an abundant lung selective collectin produced by the
respiratory epithelium and secreted in the airway. In vitro SP-A
enhanced phagocytosis and killing of microbial pathogens. To directly
determine the role of SP-A in vivo, gene targeted mice lacking SP-A (SP-
A-/-) were generated. SP-A (-/-) mice are susceptible to bacterial
infection. The present application tests the hypothesis that viral
infection alters surfactant phospholipid and protein concentrations and
SP-A protects the lung from viral infection in vivo by protecting
respiratory epithelial cells from infection and enhancing phagocytosis
and modulating synthesis of free radicals by alveolar macrophages. To
determine the role of SP-A in lung defense, experiments will determine
if SP-A protects mice in vivo from respiratory syncytial virus (RSV)
infection. To determine viral clearance mechanisms modulated by SP-A,
RSV phagocytosis and generation of oxygen and nitrogen radicals by
alveolar macrophages will be assessed in the presence and absence of SP-
A. This application will determine the role and delineate mechanisms
by which SP-A provides innate immunity to prevent RSV infections. Such
data may be useful in the future in designing treatment and prevention
of viral pneumonia in susceptible patients.
The principle investigator for this proposal has completed a fellowship
in critical care medicine and is currently a Research Instructor in the
Division of Pulmonary Biology, Department of Pediatrics. Throughout her
training, she has demonstrated a continued interest in and ability to
accomplish basic science investigation. The RCA will allow the PI to
continue to develop in a research environment with many successful
independent investigators focused to pulmonary basic science and
clinical research. The experimental design on this proposal includes
challenging but, particularly in this environment, achievable goals that
will provide important knowledge to the understanding of acute lung
injury and host defense of the lung.
本申请旨在确定病毒感染的影响
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANN MARIE LEVINE其他文献
ANN MARIE LEVINE的其他文献
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{{ truncateString('ANN MARIE LEVINE', 18)}}的其他基金
SP-A Receptor Regulation in Lung Innate Defense
肺先天防御中 SP-A 受体的调节
- 批准号:
6765152 - 财政年份:2003
- 资助金额:
$ 12.42万 - 项目类别:
SP-A Receptor Regulation in Lung Innate Defense
肺先天防御中 SP-A 受体的调节
- 批准号:
6904594 - 财政年份:2003
- 资助金额:
$ 12.42万 - 项目类别:
SP-A Receptor Regulation in Lung Innate Defense
肺先天防御中 SP-A 受体的调节
- 批准号:
7228589 - 财政年份:2003
- 资助金额:
$ 12.42万 - 项目类别:
SP-A Receptor Regulation in Lung Innate Defense
肺先天防御中 SP-A 受体的调节
- 批准号:
7122068 - 财政年份:2003
- 资助金额:
$ 12.42万 - 项目类别:
SP-A Receptor Regulation in Lung Innate Defense
肺先天防御中 SP-A 受体的调节
- 批准号:
6677946 - 财政年份:2003
- 资助金额:
$ 12.42万 - 项目类别:
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