MRI Study of Aggressive Individuals

描述（由申请人提供）：虽然某些生物行为关系 已经在冲动性攻击（例如大脑血清素）中进行了广泛的研究， 结构MRI研究尚未在患有 反复发作的有问题的冲动性攻击本研究的目的是 收集有关可能涉及以下方面的特定大脑区域的数据： 冲动性攻击将从以下受试者中收集神经影像学数据： 符合间歇性爆炸性疾病（IED）的诊断标准， 非精神病对照组。高分辨率磁共振成像 方法将用于确定特定的感兴趣区域是否 减少或改变了冲动性攻击者的大脑。 具体而言，将推导眼眶和背外侧的体积测量值 前额区和杏仁核。整个大脑和半球的体积将 也被评价。神经影像学数据将在其他 实验室和个性变量。选择实验室任务将用于 评估IED受试者是否存在涉及前额叶的认知障碍证据 和杏仁核功能此外，冲动性和 攻击性也将使用各种有效的心理测量来量化。 仪器.这些信息将用于识别解剖和认知 分别与冲动性和攻击性的严重程度相关。的 脑结构异常的存在或不存在与 了解冲动性攻击的病因在此期间获得的数据 这项研究将得出有关大脑结构的发现， 冲动性攻击，并提供有关致病因素的见解， 间歇性爆发性障碍。

DESCRIPTION (provided by applicant): While certain bio-behavioral relationships have been extensively studied in impulsive aggression (e.g. brain serotonin), structural MRI studies have not yet been performed among individuals with recurrent, problematic impulsive aggression. The aim of this study is to collect data concerning specific brain regions that may be involved in impulsive aggression. Neuroimaging data will be collected from subjects who meet diagnostic criteria for Intermittent Explosive Disorder (IED) and from non-psychiatric control subjects. High-resolution Magnetic Resonance Imaging methods will be used to determine whether specific regions of interest are reduced or altered in the brains of impulsive aggressive subjects. Specifically, volumetric measures will be derived for orbital and dorsolateral prefrontal areas and for the amygdala. Whole brain and hemispheric volumes will also be evaluated. Neuroimaging data will be evaluated in the context of other laboratory and personality variables. Select laboratory tasks will be used to evaluate IED subjects for evidence of cognitive impairment involving prefrontal and amygdalar function. In addition, individual differences in impulsivity and aggression will also be quantified using various validated psychometric instruments. This information will be used to identify anatomic and cognitive correlates of the severity of impulsivity and aggression, respectively. The presence or absence of structural brain abnormalities is relevant to an understanding of the etiology of impulsive aggression. Data obtained in this study will yield findings regarding brain structures potentially involved in impulsive aggression and provide insights concerning etiological factors in Intermittent Explosive Disorder.