DIGITAL MAMMOGRAPHY HIGH RESOLUTION FLAT PANEL IMAGER

数字乳腺X线摄影高分辨率平板成像仪

• 批准号: 6633865
• 负责人: Andrew Karellas
• 金额: $ 50.55万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6633865
• 关键词: biomedical equipment development; calcification; charge coupled device camera; digital imaging; fiber optics; human data; mammography

DESCRIPTION (Adapted from Applicant's Abstract): This is a Bioengineering Research Partnership between UMass Medical School and Lockheed-Martin Corporation. It is aimed at developing and evaluating a new high resolution flat panel mammographic imager with a variable pixel size (40 microns and 80 microns) using tiled charged-coupled devices (CCD). The detector will cover an area essentially the same as the sensitive area of a conventional mammographic cassette. The specific hypotheses are: (a) the new imager will exhibit better detective quantum efficiency (DQE) than current screen-film technology. (b) Unlike current screen-film, the system will exhibit higher dynamic range. (c) The spatial resolution will be higher than current flat-panel imaging systems due to the smaller pixel size and 100 percent fill factor. (d) The contrast will be significantly better than existing screen-film systems resulting in better visualization of breast anatomy at a reduced radiation dose to the patient due to the improved DQE. (e) A well-designed mammographic system driven in an optimized acquisition mode will replace screen-film systems for full-breast mammographic imaging. Preliminary computational and experimental studies suggest that a CCD flat panel detector of this type is feasible. The experimental plan calls for comprehensive evaluation of the characteristics of the detector and evaluation of the system though objective and universally accepted metrics such as the spatially dependent modulation transfer function and DQE. The applicants report experience with the 100 micron pixel GE clinical evaluation prototype in a screening population, which appears to demonstrate equivalency for cancer detection with similar sensitivities. However, there are concerns about of the more subtle forms of calcifications such as punctate and amorphous. When calcium is seen the edge sharpness does not appear to have the same sharpness as that of spot film views. These problems may be related to the relatively large pixel size (100 microns) of the detector. The applicants propose to develop and evaluate the next generation of high resolution digital mammography with high spatial resolution and without the detrimental loss in the signal-to-noise ratio, which is common with the older generation, which uses demagnifying fiberoptics. The proposed prototype using an array of seamlessly tiled CCDs coupled to a structured CsI:TI scintillator by a non-tapering fiberoptic plate will deliver the highest resolution than any other flat panel mammographic detector.

描述（根据申请人的摘要改编）：这是一个生物工程 UMass医学院和洛克希德 - 马丁之间的研究合作伙伴关系 公司。它旨在制定和评估新的高分辨率 具有可变像素尺寸的平板乳房X线X摄影成像仪（40微米和80 使用瓷砖充电耦合设备（CCD）的微米）。检测器将涵盖 区域基本与传统乳房X线摄影的敏感区域相同 录音带。具体假设是：（a）新成像器将表现得更好 侦探量子效率（DQE）比当前的屏幕膜技术。 （b） 与当前的屏幕膜不同，该系统将显示更高的动态范围。 （C） 空间分辨率将高于当前平板成像系统 由于像素尺寸较小和100％填充因子。 （d）对比 将比现有的屏幕膜系统要好得多，导致 更好地可视化乳房解剖学以减少辐射剂量的乳房解剖结构 由于DQE的改善，患者。 （e）精心设计的乳房X线摄影系统驱动 在优化的采集模式下，将替换屏幕膜系统的系统 全胸乳房X线照相成像。初步计算和实验 研究表明，这种类型的CCD平板检测器是可行的。这 实验计划要求对特征进行全面评估 虽然客观和普遍的探测器和评估 接受的指标，例如空间依赖的调制传输函数 和DQE。申请人报告100微米像素GE临床的经验 筛选人群中的评估原型，这似乎证明了 具有相似敏感性的癌症检测的等效性。但是，有 对诸如点状和钙化形式的更微妙形式的担忧 无定形。当看到钙时，边缘清晰度似乎没有 与现场电影视图相同的清晰度。这些问题可能与 检测器的相对较大的像素大小（100微米）。申请人 建议开发和评估下一代高分辨率数字 具有高空间分辨率的乳房X线摄影，没有有害的损失 信噪比，这与老年一代很常见，这是 使用消除纤维晶体。提出的原型使用 无缝瓷砖CCD耦合到结构化的CSI：ti闪烁体 非尖端的纤维板将提供最高的分辨率 其他平板乳房X线照相探测器。

项目成果

Scatter radiation in digital tomosynthesis of the breast.

乳房数字断层合成中的散射辐射。

• DOI: 10.1118/1.2428404
• 发表时间: 2007
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Sechopoulos,Ioannis;Suryanarayanan,Sankararaman;Vedantham,Srinivasan;D'Orsi,CarlJ;Karellas,Andrew
• 通讯作者: Karellas,Andrew