Upright, Low-dose, High-resolution, 3D Breast CT

立式、低剂量、高分辨率、3D 乳腺 CT

• 批准号: 9810897
• 负责人: Andrew Karellas
• 金额: $ 76.37万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9810897
• 关键词: 3-Dimensional; Address; Anatomy; Arizona; Benchmarking; Benign; Biomedical Engineering; Breast; Breast Cancer Detection; Breast Microcalcification; Breast-Conserving Surgery; Categories; Chest wall structure; Clinical; Clinical Trials; Data; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Sensitivity; Diagnostic radiologic examination; Digital Breast Tomosynthesis; Digital Mammography; Dimensions; Discrimination; Disease; Dose; Early Diagnosis; Eligibility Determination; Emerging Technologies; Enhancing Lesion; Evaluation; Feasibility Studies; Future; Generations; Geometry; Goals; Image; Imagery; Information Systems; Lesion; Low Dose Radiation; Malignant - descriptor; Mammography; Measurement; Modality; Modeling; Monitor; Multimodal Imaging; Neoadjuvant Therapy; Noise; Operative Surgical Procedures; Patients; Performance; Phase; Physics; Population; Positioning Attribute; Radiation Dose Unit; Radiology Specialty; Reader; Receiver Operating Characteristics; Reporting; Research; Research Project Grants; Resolution; Risk; Roentgen Rays; Sampling; Scanning; Screening procedure; Shapes; State-of-the-Art Reviews; Subgroup; System; Techniques; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Tissues; Translating; Translational Research; Universities; Validation; Woman; X-Ray Computed Tomography; base; breast cancer diagnosis; breast density; breast imaging; calcification; cancer imaging; chemotherapy; clinical decision-making; clinical practice; clinical translation; cohort; design; diagnosis evaluation; diagnostic accuracy; imaging detector; imaging system; improved; innovation; malignant breast neoplasm; next generation; predicting response; prospective; prototype; quantitative imaging; quantum; reconstruction; recruit; response; screening; simulation; study characteristics; tomography; tool; treatment planning; tumor

ABSTRACT Dedicated breast CT can eliminate tissue superposition that contributes to false-positives and false- negatives, and alleviates the need for physical compression of the breast. It provides for 3D images at near-isotropic spatial resolution that allows for viewing the breast in any orientation without the need for repeat acquisitions. It is an emerging technology, with only about five teams conducting research, worldwide. In order to develop, evaluate, accelerate its clinical translation, and to facilitate the widespread clinical adaptation of this technology, we are collaborating with GE Global Research to develop an upright patient positioning geometry with advanced technological capabilities designed to eventually allow for breast cancer screening, in addition to diagnostic imaging. The technological advanced proposed include an x-ray imaging detector with reduced system (electronic) noise, data readout rates improved by a factor of at least 2, and improved spatial sampling (pixel pitch) by a factor of 2 or more; a short-scan acquisition trajectory with angular range not exceeding 270-degrees that will improve patient positioning; and, the use of model-based iterative reconstruction techniques. All these technological advances are focused on improving posterior coverage, reducing the radiation dose to the breast so that it is similar to a standard 2- view mammography exam, and improving the visualization of microcalcifications; all with an aim of making it suitable for breast cancer screening in the future. Importantly, the upright geometry allows for rapid clinical adaptation as it allows for easy replacement of mammography and digital breast tomosynthesis systems, even in small mammography rooms, and addresses the patient discomfort observed with the prone breast CT. The research is broadly organized in two phases. In the first phase, all design factors and operational parameters will be verified through physics-based numerical simulations and empirical studies using the bench-top prototype system. In the second phase, we will conduct a clinical feasibility study that will recruit subjects from two cohorts: BIRADS 4/5, and screening population, to determine if the advanced technological approach using the upright, low-dose, high-resolution dedicated breast CT system improves the diagnostic accuracy compared to digital breast tomosynthesis. To our knowledge, this will be first study to directly compare digital breast tomosynthesis with dedicated breast CT. Thus, the proposed research will develop an innovative design concept for unprecedented impact in breast cancer imaging that will enable breast imaging without physical compression and at radiation dose similar to mammography. To our knowledge a compression-free breast CT system incorporating the aforementioned features does not exist.

抽象的 专用的乳房CT可以消除有助于假阳性和假阳性的组织叠加 负面因素，并减轻需要对乳房进行物理压缩的需求。它提供了3D图像 近乎异端的空间分辨率，可以在任何方向上查看乳房，而无需 重复获取。这是一项新兴技术，只有大约五个团队进行研究， 全世界。为了开发，评估，加速其临床翻译，并促进广泛的 这项技术的临床适应，我们正在与GE Global Research合作开发直立 具有高级技术能力的患者定位几何形状，旨在最终允许 除诊断成像外，乳腺癌筛查。技术高级提议包括 具有降低系统（电子）噪声的X射线成像检测器，数据读数率提高了一倍 至少2个，并改善了空间采样（像素沥青）2倍或更多；短扫描的收购 角度范围不超过270度的轨迹，可以改善患者定位；而且，使用 基于模型的迭代重建技术。所有这些技术进步都集中在 改善后覆盖范围，将辐射剂量减少到乳房，以便与标准2-相似 查看乳房X线摄影检查并改善微钙化的可视化；所有目标是实现 适用于将来的乳腺癌筛查。重要的是，直立的几何形状允许快速临床 适应，因为它可以轻松替换乳房X线摄影和数字乳房合成系统， 即使在小乳房X线摄影室，也可以解决俯卧乳房观察到的患者不适 CT。这项研究分为两个阶段。在第一阶段，所有设计因素和操作 参数将通过基于物理学的数值模拟和经验研究来验证参数 台式原型系统。在第二阶段，我们将进行临床可行性研究，以招募 来自两个队列的受试者：Birads 4/5和筛查人口，以确定是否高级 使用直立的低剂量，高分辨率专用乳房CT系统改进的技术方法 与数字乳房合成相比，诊断精度。据我们所知，这将是首次研究 直接将数字乳房断层合成与专用的乳房CT进行比较。因此，拟议的研究将 开发一种创新的设计概念，以实现乳腺癌成像中前所未有的影响，这将使 乳房成像无物理压缩和辐射剂量类似于乳房X线摄影。向我们 知识不存在包含上述特征的无压缩乳房CT系统。