HIGH RESOLUTION CARDIOVASCULAR FLAT-PANEL X-RAY IMAGER

高分辨率心血管平板 X 射线成像仪

• 批准号: 6704089
• 负责人: Andrew Karellas
• 金额: $ 58.05万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6704089
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cardiovascular imaging /visualization; charge coupled device camera; cineangiocardiography; digital imaging; fluoroscopy; image enhancement

Recent advances in cardiovascular imaging have contributed to the development of new, widely used lifesaving x-ray interventional procedures. This has prompted concerns about the radiation dose- efficiency of present equipment and techniques. When the equipment is not capable of delivering excellent image quality for visualizing subtle or small vasculature required for challenging diagnostic or therapeutic interventional procedures, physicians have little choice but to prolong fluoroscopy or acquire more cine views. This research is aimed at designing, developing and evaluating a new type of high resolution imaging device for cardiac x-ray fluoroscopy and cine imaging. This effort follows the successful research conducted by our group in the past four years to adapt charge-coupled device (CCD) technology to digital mammographic imaging applications. The device will be a CCD-based flat panel detector consisting of four 8 cm x 8 cm CCDs joined in a seamless design to form an area of 16 cm x 16 cm (6.3 x 6.3 inch, 8.9 inch diagonal). The design takes advantage of the low-noise characteristics for which CCDs are known, with a new interline charge transfer design for 30 frame/s or even 60 frames/s fluoroscopic video. The proposed detector and technique circumvents problems due to image lag (smearing), associated with other types of flat panel detectors and is radically different from any other detector of its kind. As far as we know, large scientific grade CCDs have never been developed to operate in the interline transfer mode for video frame rate imaging for x-ray fluoroscopy or any other application. Our system will be x-ray quantum-noise limited and unlike image intensifier systems, it will be free of geometric distortion and veiling glare effects which cause significant loss of contrast. The new system will be able to deliver better detective quantum efficiency (DQE) and spatial resolution in both fluoroscopic and radiographic modes than existing image intensifier-based systems. The improved contrast characteristics would enable better visualization of cardiovascular anatomy and functionality at a reduced radiation dose to the patient. The research will involve the design and manufacturing of the CCD which will be followed by comprehensive adaptation of the device to the fluoroscopic and radiographic tasks. Investigation of the imaging characteristics of the detection system will be conducted through objective and universally accepted metrics such as modulation transfer function (MTF) and frequency dependent detective quantum efficiency (DQE).

心血管成像的最新进展促进了新的、广泛应用的挽救生命的x射线介入手术的发展。这引起了人们对现有设备和技术的辐射剂量效率的关注。当设备不能提供优秀的图像质量，以显示具有挑战性的诊断或治疗性介入程序所需的细微或小血管时，医生别无选择，只能延长透视时间或获得更多的电影视图。本研究旨在设计、开发和评估一种用于心脏x线透视和电影成像的新型高分辨率成像装置。在过去的四年中，我们小组成功地将电荷耦合器件（CCD）技术应用于数字乳房x线摄影成像应用。该器件将是一个基于ccd的平板探测器，由四个8厘米× 8厘米的ccd组成，以无缝设计连接，形成16厘米× 16厘米（6.3 × 6.3英寸，8.9英寸对角线）的面积。该设计利用ccd众所周知的低噪声特性，采用新的线间电荷转移设计，可实现30帧/秒甚至60帧/秒的荧光视频。所提出的探测器和技术规避了与其他类型的平板探测器相关的图像滞后（涂抹）问题，并且与任何其他同类探测器根本不同。据我们所知，大型科学级ccd从未被开发用于x射线透视或任何其他应用的视频帧率成像的行间传输模式。我们的系统将受到x射线量子噪声的限制，与图像增强系统不同，它将不会产生几何畸变和遮挡眩光效应，从而导致对比度的显著损失。与现有的基于图像增强器的系统相比，新系统将能够在荧光和射线成像模式下提供更好的探测量子效率（DQE）和空间分辨率。在降低患者的辐射剂量下，增强的对比特性将使心血管解剖和功能更好地可视化。该研究将涉及CCD的设计和制造，随后将对该设备进行全面改造，以适应透视和射线成像任务。探测系统的成像特性研究将通过客观和普遍接受的指标，如调制传递函数（MTF）和频率相关探测量子效率（DQE）进行。

项目成果

Solid-state fluoroscopic imager for high-resolution angiography: parallel-cascaded linear systems analysis.

用于高分辨率血管造影的固态荧光成像仪：并行级联线性系统分析。

• DOI: 10.1118/1.1689014
• 发表时间: 2004
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Vedantham,Srinivasan;Karellas,Andrew;Suryanarayanan,Sankararaman
• 通讯作者: Suryanarayanan,Sankararaman

Solid-state fluoroscopic imager for high-resolution angiography: physical characteristics of an 8 cm x 8 cm experimental prototype.

用于高分辨率血管造影的固态荧光成像仪：8 厘米 x 8 厘米实验原型的物理特性。

• DOI: 10.1118/1.1750992
• 发表时间: 2004
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Vedantham,Srinivasan;Karellas,Andrew;Suryanarayanan,Sankararaman;Onishi,StevenK
• 通讯作者: Onishi,StevenK