BIOELECTRONIC MICROARRAY FOR DNA ANALYSIS

在这个项目中，我们提出了一种新的寡核苷酸检测技术，该技术通过检测杂交双链的生物电子响应来工作。与传统的染料标记低聚物检测方法相比，该电化学检测器具有明显的优势。电化学传感可以使用相对简单的设备来实现。可以在溶液中进行分析。在所提出的方法中，不需要对目标分子进行标记。当完全开发时，以前为成像应用开发的高度集成的电子芯片可以进行修改，并可用作新一代廉价、一次性的电化学DNA微阵列传感器。

In this project, we propose a new detection technology for identification of oligonucleotides, which works by detecting a bio-electronic response from hybridized duplexes. Compared with the conventional approach of using dye tagged oligos, the proposed electrochemical detector has significant advantages. Electrochemical sensing can be implemented using relatively simple equipment. Analysis can be performed in solution. In the proposed approach, no tagging of target molecules is required. When fully developed, highly integrated electronic chips, previously developed for imaging applications, can be modified and can be used as a new generation of inexpensive, disposable, electrochemical DNA microarray sensors.