Genomic Labware with Protein 'Non-Stick' Surfaces
Genomic Labware with Protein 'Non-Stick' Surfaces
批准号:
6587030
负责人:
Joel L Williams
金额:
$9.88万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-02-01 至 2003-12-31
中文摘要
描述(由申请人提供):基因组研究的爆炸性领域有望在医疗保健方面取得许多革命性进展,但目前正受到商业实验室工具的“阻碍”,这些实验室工具含有大量加工助剂和霉菌释放添加剂,这些添加剂要么“结合”蛋白质,要么释放到基因组研究中使用的稀释蛋白质溶液中。该项目的主要目标是开发一次性实验室用品,最大限度地减少蛋白质“粘”在血管壁上的问题,这些问题阻碍了基因组研究的进展,这对改善未来的医疗保健至关重要。Genomex的目标是成为不干扰脆弱蛋白质研究的基因组社区的高清晰度表面修饰实验室用品的首要供应商。该计划的更具体目标是开发由新型塑料表面制成的实验室用品,以最大限度地减少蛋白质表面。将使用碘-125标记的蛋白质测试永久修饰的表面的结合特性。第一阶段的所有研究将在5厘米的培养皿上进行。在该产品商业化后,基因组研究人员将能够选择最适合他们感兴趣的蛋白质的确切表面,而无需费力的预处理或涂覆容器内壁。
英文摘要
DESCRIPTION (provided by applicant): The exploding field of genomic research, which promises many revolutionary advances in healthcare, is currently being "hindered" by commercial lab ware that contains numerous processing aids and mold release additives that either 'bind" proteins or release into the dilute solutions of proteins used in genomic research. The major objective of this program is to develop disposable lab ware products that minimize the problems of proteins "sticking" to vessel walls that retard this progress in genomic research so vital to improving future healthcare. It is the goal of Genomex to be the premier supplier of high definition surface modified lab ware products for the genomic community that do not interfere with fragile protein research. More specific goals of this program are the development of lab ware products that are made from novel plastic surfaces to minimize protein surfaces. The permanently modified surfaces will be tested in terms of binding properties using iodine-125 labeled proteins. All studies on the first phase will be on 5-cm petri dishes. Upon commercialization of this product, the genomic researcher will be able to select the exact surface that works best for their protein of interest without the need for laborious preconditioning or coating the interior walls of the container.
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会议论文
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