Unique Antimicrobial Catheter to Prevent Urinary Tract Infections

独特的抗菌导管可预防尿路感染

• 批准号: 8591127
• 负责人: Joel L Williams
• 金额: $ 18.29万
• 依托单位: BRIGHTON DEVELOPMENT, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-18 至 2015-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8591127
• 关键词: Anti-Bacterial Agents; Antibiotics; Catheters; Cell Survival; Cessation of life; Development; Devices; Dose; Elastomers; FDA approved; Feasibility Studies; Filler; Formaldehyde; Goals; Health Care Costs; Health Priorities; Healthcare; Human; Infection; Infection prevention; Length of Stay; Local Anti-Infective Agents; Manufactured Materials; Measurement; Measures; Mechanics; Medical; Methenamine; Molds; Oxides; Patients; Phase; Polymers; Process; Product Packaging; Property; Services; Silicon Dioxide; Silicone Elastomers; Source; Sterilization; Surface; Technology; Testing; Time; United States National Institutes of Health; Urinary tract; Urinary tract infection; antimicrobial; antimicrobial drug; base; carbene; catheter associated UTI; controlled release; cost; delrin; depolymerization; design; innovation; irradiation; manufacturing process; melting; monomer; novel strategies; pathogen; physical property; prevent; prototype; public health relevance; research and development; response; urinary

DESCRIPTION (provided by applicant): The goal of this Phase I effort is determine the feasibility of developing a unique antimicrobial catheter to reduce the instances of the most prevalent healthcare associated infection, Catheter-Associated Urinary Tract Infection (CAUTI). This research and development effort will be to develop a urinary catheter with inherent long lasting antiseptic properties to protect the patient and prevent infection. The proposed device is a new approach to antimicrobial catheters. It will use common Foley catheter designs and materials, with the addition of an additive to the elastomer to render the catheter antimicrobial. The additive replaces the silica reinforcing filler in the elastomer and is designed to give a long lasting time release of antibacterial agent to the catheter surface. The catheter can be manufactured inexpensively with standard medical tubing manufacturing processes and materials, but will have the value-added property of antimicrobial activity. A durable and effective antimicrobial catheter that can prevent or reduce CAUTI will save millions of dollars in healthcare cost and thousands of lives annually.

描述（由申请人提供）：I阶段努力的目的是确定开发独特的抗菌导管以减少最普遍的医疗保健相关感染，导管相关的尿路感染（CAUTI）的可行性。这项研究和开发工作将是开发具有固有持久抗菌特性的尿导管，以保护患者并防止感染。提出的设备是一种抗菌导管的新方法。它将使用常见的Foley导管设计和材料，并在弹性体中添加添加剂来渲染导管抗菌剂。添加剂代替了弹性体中的二氧化硅加固填充剂，旨在提供长时间 抗菌剂对导管表面的持续时间释放。该导管可以通过标准的医用管制造工艺和材料廉价地制造，但具有抗菌活性的增值特性。一种可以预防或减少CAUTI的耐用且有效的抗菌导管，每年可节省数百万美元的医疗费用和数千美元的生命。