Predicting individual risk of cognitive decline in women

预测女性认知能力下降的个体风险

• 批准号: 6683757
• 负责人: JENNIFER L ETNIER
• 金额: $ 7.48万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6683757
• 关键词: Alzheimer's disease; aerobic exercise; aging; apolipoprotein E; body physical activity; clinical research; cognition; cognition disorders; community; disease /disorder proneness /risk; female; genotype; human middle age (35-64); human old age (65+); human subject; mental health epidemiology

19. Genetics, Behavior and Aging. The epsilon 4 allele of apolipoprotein E (ApoE-e4) has been identified as a genetic risk factor for cognitive impairment, cognitive decline, and the experience of Alzheimer's Disease (AD). However, the presence of ApoE-e4 does not guarantee these cognitive outcomes. Therefore, one important direction for future research is to identify variables that may interact with ApoE genotype to determine cognitive outcomes. Physical activity is a behavioral variable that may play a role in the expression of the ApoE genotype relative to cognition. Physical activity has been shown to be associated with better cognitive abilities and with lessened cognitive decline with age. Further, the effects of physical activity on cognition have been shown in men to be moderated by ApoE genotype. Thus, the primary purpose of the proposed study is to add to the extant literature by testing the interactive effects of physical activity and ApoE genotype on the cognitive performance of a sample of older women. The literature will also be extended by assessing aerobic fitness which will provide insight into the causal mechanisms which may underlie the relationships being tested. Community-dwelling older women (50-80 years) who have a family history of AD will be recruited. Participants will perform a battery of cognitive tests, will have their blood drawn to determine their ApoE genotype, will complete a physical activity questionnaire, and will perform a maximal aerobic fitness test. It is hypothesized that the beneficial effects of physical activity and aerobic fitness on cognitive performance will be moderated by the presence of the ApoE-4 allele. Regression analyses will be used to test these effects. This study will advance our knowledge about the behavioral variables that modify genetic risk for cognitive impairment in older women. ApoE-4 is well established as a risk factor for cognitive decline and for the experience of AD. However, behavioral variables such as physical activity may impact the expression of this genetic risk factor and this study will extend our knowledge regarding this relationship. Additionally, the findings of this study will have important implications for identifying participants for whom physical activity may be especially beneficial with regards to cognition.

19.遗传、行为和衰老。载脂蛋白E（ApoE-e4）的E14等位基因已被确定为认知障碍、认知下降和阿尔茨海默病（AD）经历的遗传风险因素。然而，ApoE-e4的存在并不能保证这些认知结果。因此，未来研究的一个重要方向是确定可能与ApoE基因型相互作用的变量，以确定认知结果。体力活动是一种行为变量，可能在ApoE基因型相对于认知的表达中发挥作用。体育活动已被证明与更好的认知能力有关，并与随着年龄的增长而减少的认知衰退有关。此外，身体活动对认知的影响已被证明在男性中受ApoE基因型的调节。因此， 本研究拟通过测试体力活动和ApoE基因型对老年妇女认知能力的交互作用，来补充现有的文献。文献也将通过评估有氧健身，这将提供深入了解的因果机制，可能是被测试的关系的基础。将招募有AD家族史的社区老年女性（50-80岁）。参与者将进行一系列认知测试，抽血以确定他们的ApoE基因型，完成体力活动问卷，并进行最大有氧健身测试。据推测，身体活动和有氧健身对认知能力的有益影响将被ApoE-4等位基因的存在所调节。回归分析将用于测试这些影响。这项研究将促进我们对行为变量的了解，这些变量改变了老年妇女认知障碍的遗传风险。ApoE-4被公认为认知能力下降和AD经历的风险因素。然而，身体活动等行为变量可能会影响这种遗传风险因素的表达，这项研究将扩展我们对这种关系的了解。此外，这项研究的结果将对确定参与者的身体活动可能对认知特别有益具有重要意义。