Distilling the relationship of parental psychiatric illness to offspring productivity and social outcomes: evidence base for preventive strategies

提炼父母精神疾病与后代生产力和社会结果的关系：预防策略的证据基础

• 批准号: 10708878
• 负责人: Ashley Nordsletten
• 金额: $ 7.8万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2023-11-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708878
• 关键词: Adult; Affect; Area; Attention; Behavioral; Characteristics; Child; Child Health; Child Rearing; Child Support; Cognitive; Conduct Disorder; Data; Data Analyses; Data Set; Data Sources; Development; Diagnosis; Diagnostic; Disease; Dissection; Divorce; Education; Educational Status; Emotional; Employment; Ensure; Environment; Etiology; Failure; Family; Fathers; Generations; Genetic; Goals; Growth; Health; Heritability; Impaired health; Income; Individual; Intervention; Investigation; Left; Life; Life Cycle Stages; Life Expectancy; Link; Literature; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Mentally Ill Persons; Mothers; Occupational; Outcome; Parents; Partner in relationship; Pathway interactions; Personal Satisfaction; Play; Population; Post-Traumatic Stress Disorders; Prevention strategy; Productivity; Proliferating; Psychiatric Diagnosis; Psychopathology; Public Health; Quasi-experiment; Research; Research Design; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Schizophrenia; Schools; Shapes; Signal Transduction; Social Behavior; Social outcome; Socioeconomic Status; Spouses; Stress; Structure; Substance abuse problem; Suicide; Variant; Work; behavioral economics; child bearing; design; early childhood; economic outcome; emerging adult; emotion regulation; evidence base; experience; family structure; family support; father role; high risk; insight; interest; intergenerational; knowledge base; negative affect; next generation; novel; offspring; parental role; physical conditioning; postnatal; power analysis; psychologic; self esteem; sex; skill acquisition; skills; social; social anxiety; social engagement; socioeconomic disadvantage; socioeconomics; success

PROJECT SUMMARY It is well established that parents play a critical role in setting the life trajectory of their children: predisposing their academic and social engagement, and ensuring an environment conducive to healthy development and goal fulfilment. Skills that will form the basis for social and socioeconomic success (e.g., attention, interpersonal ability), begin to shape early in life, with familial risk factors - such as low parental income, education, or health – negatively affecting such skill development. Children who face either more, or more long-term risk, factors are more likely to experience negative impacts extending from productivity (e.g., educational achievement), to socio- behavioural functioning (e.g., criminality), and the attendant challenges of each (e.g., reduced employment stability, impaired physical and mental health, lower life-expectancy) Prior research has suggested a particular relationship between parental mental illness and diminished outcomes across these domains in the next generation. However, the common practice of distinctly investigating maternal or (less commonly) paternal mental health – as opposed to unified investigation of the whole family unit - has limited insight into sex-differential effects and precluded investigation of risk dynamics by parent’s individual (or, where both parents are affected, combined) diagnoses. Further, the relative importance of parental mental health, as compared to alternative features with known impacts on child health and life opportunity (e.g., family socioeconomic status, offspring’s own mental health), remains largely unexplored. This fragmented approach has left, unquantified, the mechanistic role of parental mental health in cross-generational life outcomes – a point of public health concern given (1) the relationship of these outcomes (e.g., years of education, employment stability, criminality) to both the quality and duration of life, (2) the high proportion of Western children living with at least one mentally ill parent (11-18.2%), and (3) the rising rates of stress, mental illness, and related outcomes (e.g., suicide), among adults in these populations. The current project aims to assess the degree to which psychiatric disorders in parents impact key life outcomes (educational attainment, occupational stability, criminality) in the next generation, via analyses which allow these relationships to be enumerated and the underlying mechanisms parsed. Our aims – to 1) quantify the association of parental psychopathology (dual- vs. single-affected families; within vs. cross-disorder pairings) with offspring outcomes across the life-course; 2) assess the potentially differential effects of specific disorders on these associations; 3) examine the relationship of genetics and environment to these outcomes; and 4) disentangle the pathways through which familial environments interplay with offspring characteristics to impact the associations under study – have been designed to provide the mechanistic data needed to inform preventive strategies, aimed at parenting and family support to intervene in the relationship between parental mental health and children’s life outcomes.

项目总结