HABS-HD - Core E - Disparities & Outreach Core

HABS-HD - 核心 E - 差异

• 批准号: 10708877
• 负责人: Sid E O'Bryant
• 金额: $ 73.67万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708877
• 关键词: Address; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Awareness; Back; Biological Markers; Brain; Clinical; Cognitive aging; Collaborations; Communities; Community Networks; Community Outreach; Data; Development; Disparate; Disparity; Education; Education and Outreach; Educational Materials; Ensure; Ethnic Population; Event; Feedback; Focus Groups; Funding; Future; Goals; Health; Health Disparities Research; Hispanic Populations; Home; Individual; Informatics; Infrastructure; Institution; Life Cycle Stages; Linguistics; Location; Measures; Methods; Mexican Americans; Minority Groups; Monitor; Newsletter; Not Hispanic or Latino; Participant; Population; Population Heterogeneity; Prevention strategy; Procedures; Process; Protocols documentation; Publications; Race; Research; Research Methodology; Scientist; Spinal Puncture; Students; Training; Underrepresented Minority; Work; aged; aging brain; cohort; community engagement; ethnic minority population; health disparity; health goals; improved outcome; information gathering; member; multi-ethnic; neuroimaging; novel; outreach; precision medicine; racial minority population; racial population; recruit; social media; treatment strategy

HABS-HD DISPARITIES & OUTREACH CORE (CORE E) - ABSTRACT One of the primary goals of the National Alzheimer’s Project Act (NAPA) is to “improve outcomes for ethnic and racial minority populations.” However, substantial gaps in understanding the reasons for the disparate increase in Alzheimer’s disease (AD) and AD related disorders (ADRDs) in ethnic and racial minority populations exist, primarily due to the underrepresentation of minority groups in aging research. Community engagement and outreach is considered one of the most successful strategies to recruiting diverse populations into research. The Dallas Forth-Worth (DFW) metroplex, home to the Health and Aging Brain Study-Health Disparities (HABS-HD), is currently reflective of the future U.S. racial/ethnic population and an ideal location to simultaneously study cognitive aging among African Americans (AA), Mexican Americans (MA; 63% of the U.S. Hispanic population) and non-Hispanic whites (NHW). HABS-HD is the first large-scale, community-based project to simultaneously study each of the AT(N) defined biomarkers, in alignment with the NIA Health Disparities Research Framework. The long-term goal of HABS-HD is to establish population-specific informed precision medicine for novel treatment and prevention strategies as called for in NIA AD+ADRD Research Implementation Milestone 1. For nearly 10 years, HABS-HD has built a network of community ties and relationships using a community-based approach to recruitment. This approach, which emphasized outreach, engagement, and collaboration between the research team and key stakeholders in the community, led to the successful recruitment of 2,000 participants (n=1,000 NHW, 1,000 MA) aged 50 and older and longitudinal follow-ups are underway. Based on UNTHSC Institutional funding, the cohort has expanded to include 1,000 AAs with recruitment to be completed prior to initiation of this U19. As part of the proposed U19, the primary goal of the Core E is to further increase awareness and engagement of diverse communities into research and to provide the outreach infrastructure to comprehensively understand the development and progression of AD and ADRDs across the lifecourse. To address this goal, Core E will address the following Specific Aims: Aim 1: Extend the recruitment of the HABS-HD cohort to ages 30-49 (n=500 per racial/ethnic group), retain existing participants, and recruit new participants to counteract attrition. Aim 2: Generate and disseminate educational materials regarding the importance of brain aging over the lifecourse and the importance of research in diverse communities. Aim 3: In collaboration with all Cores and Projects, continue to monitor and ensure that all HABS-HD activities are conducted in alignment with the NIA Health Disparities Research Framework.

HABS-HD差异和外延核心（核心E）-摘要 国家阿尔茨海默病项目法案（NAPA）的主要目标之一是“改善种族 和少数民族人口。”然而，在理解不同的原因方面存在着巨大的差距， 少数民族和种族中阿尔茨海默病（AD）和AD相关疾病（ADRD）增加 少数群体的存在，主要是由于少数群体在老龄化研究中的代表性不足。社区 参与和推广被认为是招募不同人群的最成功的策略之一 投入研究达拉斯福斯沃思（DFW）大都市，健康和老龄化大脑研究的家园-健康 差异（HABS-HD），目前反映了未来的美国种族/民族人口和理想的位置 同时研究非洲裔美国人（AA），墨西哥裔美国人（MA; 63%的 美国非西班牙裔白人（NHW）。HABS-HD是第一个大规模的，以社区为基础的 同时研究AT（N）定义的生物标志物的项目，与NIA健康 差异研究框架。HABS-HD的长期目标是建立特定人群的知情 NIA AD+ADRD研究中呼吁的新型治疗和预防策略的精准医学 实施里程碑1.近10年来，HABS-HD建立了一个社区联系网络， 采用基于社区的招聘方法建立关系。这一办法强调外联， 参与，以及研究团队和社区主要利益相关者之间的合作，导致了 成功招募了2，000名年龄在50岁及以上的参与者（n= 1，000名NHW，1，000名MA）， 后续行动正在进行中。在联合国人类住区中心机构供资的基础上，这一群体已扩大到包括1 000人， 在本U19开始之前完成招募的AA。作为U19计划的一部分， 核心E的目标是进一步提高不同社区对研究的认识和参与， 提供外展基础设施，以全面了解AD的发展和进展 和抗抑郁症的发病率为了实现这一目标，核心E将实现以下具体目标： 1：将HABS-HD队列的招募范围扩大至30-49岁（每个种族/族裔组n=500），保留现有的 参与者，并招募新的参与者，以抵消减员。目标2：开展和传播教育 关于大脑老化在生命过程中的重要性以及研究各种疾病的重要性的材料。 社区.目标3：与所有核心和项目合作，继续监测并确保所有 HABS-HD活动是根据NIA健康差异研究框架开展的。