HABS-HD - Core A - Admin Core

HABS-HD - 核心 A - 管理核心

• 批准号: 10708864
• 负责人: Sid E O'Bryant
• 金额: $ 114.31万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708864
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Biological Markers; Biometry; Biostatistics Core; Clinic; Clinical; Collaborations; Collection; Communication; Communities; Complement; Data; Data Collection; Decision Making; Development; Disparity; Effectiveness; Ensure; Ethnic Origin; Ethnic Population; Goals; Health; Health Disparities Research; Informatics; Institution; Institutional Review Boards; Leadership; Literature; Methods; Mission; Monitor; Not Hispanic or Latino; Participant; Patient Recruitments; Pharmaceutical Preparations; Policies; Population Heterogeneity; Positron-Emission Tomography; Principal Investigator; Procedures; Protocols documentation; Publications; Quality Control; Race; Recommendation; Reporting; Research; Research Personnel; Resources; Science; Scientific Advances and Accomplishments; Series; Structure; Tracer; Work; aging brain; data access; data access system; data dissemination; data portal; data quality; health disparity; health goals; interest; meetings; neuroimaging; outreach; programs; racial population; tau Proteins

HABS-HD ADMINISTRATIVE CORE (CORE A) - ABSTRACT Core A has been providing leadership and management to the Health & Aging Brain Study – Health Disparities (HABS-HD) study since inception and has ensured all proposed metrics have been met. Core A will continue to support the overall mission of HABS-HD to achieve the long-term goal of establishing a comprehensive understanding of AT(N) defined biomarkers across diverse populations, thereby addressing one of the most critical gaps in the existing literature as well as multiple components of NIA AD+ADRD Research Implementation Milestone 1. Given the recent approval of an anti-amyloid drug, this work is now more important than ever. The overall goal of the HABS-HD Core A is to continue to provide critical organizational oversight in order to accomplish the scientific goals and to serve as the nexus of leadership for the U19 as a whole and each of its interlocking Cores, Projects, and committees. Core A will coordinate the integrated components and activities of HABS-HD to accomplish the following aims: Aim 1: Provide organizational support and structure to the Multi Principal Investigator (MPI) team, Cores, Projects and committees. Aim 2: Continue to provide structured communication activities for the HABS-HD team. Organize and make decisions on recommendations from the Core and Project Leads and committees as well as execute those decisions. Organize and plan the annual HABS-HD meetings. Organize and be responsible for any/all NIA communications and reporting. Aim 3: Work with the Cores, Projects, Executive Committee (EC) and Steering Committee (SC) to: (a) continue to refine and monitor structure for ensuring progress towards goals for all aspects of HABS-HD including participant recruitment/retention, protocol refinement and development, participant assessments, biospecimen collection, storage and dissemination of data and biospecimens, (b) ensure timely completion of the HABS-HD Projects and (c) monitor all IRB and FDA IND (PET tau tracer) aspects of the study. Aim 4: Working with all Cores, ensure the refinement/development and public availability of all HABS-HD policies and procedures for data collection, data quality control (QC), resource (data and biospecimens) sharing and dissemination, publications, and potential new research directions. Aim 5: Work with the Neuroimaging & Informatics Core, Biostatistics Core and data teams, to generate, refine and implement a series of policies and committees to support access to data through the LONI data portal. Promote and encourage utilization of these unique and valuable data. Monitor data utilization and ensure that systems for data access are effective and efficient. Work with the Development Core to ensure access of HABS-HD data to junior investigators interested in health disparities research in AD. Aim 6: Work with all Core and Project Leads/Co-Leads to ensure maximum collaboration within the HABS-HD team. Aim 7: Work with all Cores to ensure maximum overlap with other ongoing, large-scale AD+ADRD programs to ensure cross-study comparisons and facilitate access to HABS-HD data for these other initiatives.

HABS-HD管理核心(核心A)-摘要 Core A一直在为健康与老龄化大脑研究-健康差异提供领导和管理 (HABS-HD)自成立以来进行了研究，并确保满足所有建议的指标。核心A将继续 支持HABS-HD的总体使命，以实现建立全面的 了解不同人群中AT(N)定义的生物标记物，从而解决最多的 现有文献中的关键差距以及NIA AD+ADRD研究的多个组成部分 实施里程碑1.鉴于最近批准了一种抗淀粉样蛋白药物，这项工作现在更多 比以往任何时候都重要。HABS-HD核心A的总体目标是继续提供关键的组织 监督，以实现科学目标，并作为U19作为 整个和每一个环环相扣的核心、项目和委员会。核心A将协调集成的 HABS-HD的组成部分和活动以实现以下目标：目标1：提供组织 为多负责人调查员(MPI)团队、核心、项目和委员会提供支持和结构。目标2： 继续为HABS-HD团队提供有组织的沟通活动。组织和制定决策 根据核心和项目领导和委员会的建议，并执行这些决定。 组织和计划年度HABS-HD会议。组织并负责任何/所有NIA 通信和报道。目标3：与核心、项目、执行委员会(EC)和指导合作 委员会(自然科学委员会)：(A)继续完善和监测结构，以确保在实现所有人的目标方面取得进展 HABS-HD的各个方面，包括参与者的招募/保留、方案的完善和发展， 参与者评估、生物武器收集、储存和传播数据和生物武器，(B) 确保及时完成HABS-HD项目，并(C)监测所有IRB和FDA IND(PET tau示踪剂) 研究的方方面面。目标4：与所有核心合作，确保改进/开发和公开可用 关于数据收集、数据质量控制(QC)、资源(数据和)的所有HABS-HD政策和程序 生物标本)共享和传播、出版物和潜在的新研究方向。目标5：工作 与神经成像和信息学核心、生物统计核心和数据团队一起，生成、提炼和 实施一系列政策和委员会，支持通过LONI数据门户获取数据。 促进和鼓励利用这些独特和有价值的数据。监控数据利用率并确保 数据访问系统是有效和高效的。与开发核心合作，确保访问 HABS-HD数据提供给对AD健康差距研究感兴趣的初级调查人员。目标6：与所有核心合作 以及项目负责人/联合负责人，以确保在HABS-HD团队内实现最大程度的协作。目标7：与所有人合作 核心，以确保与其他正在进行的大规模AD+ADRD计划的最大重叠，以确保交叉研究 为这些其他举措提供比较和便利获取HABS-HD数据。