HABS-HD - Core A - Admin Core
HABS-HD - Core A - Admin Core
批准号:
10493845
负责人:
Sid E O'Bryant
金额:
$115.51万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-30 至 2027-08-31
关键词:
AddressAdultAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmyloidBiological MarkersBiometryBiostatistics CoreClinicClinicalCollaborationsCollectionCommunicationCommunitiesComplementDataData CollectionDecision MakingDevelopmentEffectivenessEnsureEthnic groupGoalsHealthHealth Disparities ResearchInformaticsInstitutionInstitutional Review BoardsLeadershipLiteratureMethodsMissionMonitorNot Hispanic or LatinoParticipantPatient RecruitmentsPharmaceutical PreparationsPoliciesPopulation HeterogeneityPositron-Emission TomographyPrincipal InvestigatorProceduresProtocols documentationPublicationsQuality ControlRecommendationReportingResearchResearch PersonnelResourcesScienceSeriesStructureSystemTimeTracerWorkaging brainbasedata accessdata disseminationdata portaldata qualityhealth disparityhealth goalsinterestmeetingsneuroimagingorganizational structureoutreachprogramsracial and ethnictau Proteins
中文摘要
HABS-HD管理核心(核心A)-摘要
核心A一直在为健康与老龄化大脑研究-健康差异提供领导和管理
(HABS-HD)研究,并确保所有拟议指标都得到满足。核心A将继续
支持HABS-HD的总体使命,以实现建立一个全面的
了解不同人群中AT(N)定义的生物标志物,从而解决了其中一个最重要的问题。
现有文献以及NIA AD+ADRD研究的多个组成部分存在重大空白
实施里程碑1.鉴于最近批准的抗淀粉样蛋白药物,这项工作现在更多
比以往更重要。HABS-HD核心A的总体目标是继续提供关键的组织
监督,以实现科学目标,并作为U19的领导核心,
整个组织及其相互关联的核心、项目和委员会。核心A将协调
目标1:提供组织能力,
为多个主要研究者(MPI)团队、核心、项目和委员会提供支持和结构。目标二:
继续为HABS-HD小组提供有组织的交流活动。组织和决策
根据核心和项目领导人和委员会的建议,并执行这些决定。
组织和规划HABS-HD年度会议。组织并负责任何/所有NIA
通信和报告。目标3:与核心、项目、执行委员会和指导委员会合作
(a)继续完善和监测确保在实现人人享有的目标方面取得进展的结构
HABS-HD的各个方面,包括参与者招募/保留、方案完善和制定,
参与者评估、生物样本收集、数据和生物样本的储存和传播,(B)
确保及时完成HABS-HD项目,并(c)监测所有IRB和FDA IND(PET tau示踪剂)
研究的各个方面。目标4:与所有核心合作,确保改进/开发和公共可用性
所有关于数据收集、数据质量控制、资源(数据和
生物标本)共享和传播,出版物和潜在的新研究方向。目标5:工作
与神经成像和信息学核心,生物统计学核心和数据团队,以生成,完善和
实施一系列政策和委员会,以支持通过LONI数据门户获取数据。
促进和鼓励利用这些独特而有价值的数据。监控数据利用率并确保
数据访问系统是有效和高效的。与发展核心合作,确保
HABS-HD数据提供给对AD健康差异研究感兴趣的初级研究人员。目标6:与所有核心合作
和项目领导/共同领导,以确保HABS-HD团队内的最大协作。目标7:与所有人合作
核心,以确保与其他正在进行的大规模AD+ADRD项目的最大重叠,以确保交叉研究
比较和便利为这些其他倡议获取人居署-人类住区数据。
英文摘要
HABS-HD ADMINISTRATIVE CORE (CORE A) - ABSTRACT
Core A has been providing leadership and management to the Health & Aging Brain Study – Health Disparities
(HABS-HD) study since inception and has ensured all proposed metrics have been met. Core A will continue to
support the overall mission of HABS-HD to achieve the long-term goal of establishing a comprehensive
understanding of AT(N) defined biomarkers across diverse populations, thereby addressing one of the most
critical gaps in the existing literature as well as multiple components of NIA AD+ADRD Research
Implementation Milestone 1. Given the recent approval of an anti-amyloid drug, this work is now more
important than ever. The overall goal of the HABS-HD Core A is to continue to provide critical organizational
oversight in order to accomplish the scientific goals and to serve as the nexus of leadership for the U19 as a
whole and each of its interlocking Cores, Projects, and committees. Core A will coordinate the integrated
components and activities of HABS-HD to accomplish the following aims: Aim 1: Provide organizational
support and structure to the Multi Principal Investigator (MPI) team, Cores, Projects and committees. Aim 2:
Continue to provide structured communication activities for the HABS-HD team. Organize and make decisions
on recommendations from the Core and Project Leads and committees as well as execute those decisions.
Organize and plan the annual HABS-HD meetings. Organize and be responsible for any/all NIA
communications and reporting. Aim 3: Work with the Cores, Projects, Executive Committee (EC) and Steering
Committee (SC) to: (a) continue to refine and monitor structure for ensuring progress towards goals for all
aspects of HABS-HD including participant recruitment/retention, protocol refinement and development,
participant assessments, biospecimen collection, storage and dissemination of data and biospecimens, (b)
ensure timely completion of the HABS-HD Projects and (c) monitor all IRB and FDA IND (PET tau tracer)
aspects of the study. Aim 4: Working with all Cores, ensure the refinement/development and public availability
of all HABS-HD policies and procedures for data collection, data quality control (QC), resource (data and
biospecimens) sharing and dissemination, publications, and potential new research directions. Aim 5: Work
with the Neuroimaging & Informatics Core, Biostatistics Core and data teams, to generate, refine and
implement a series of policies and committees to support access to data through the LONI data portal.
Promote and encourage utilization of these unique and valuable data. Monitor data utilization and ensure that
systems for data access are effective and efficient. Work with the Development Core to ensure access of
HABS-HD data to junior investigators interested in health disparities research in AD. Aim 6: Work with all Core
and Project Leads/Co-Leads to ensure maximum collaboration within the HABS-HD team. Aim 7: Work with all
Cores to ensure maximum overlap with other ongoing, large-scale AD+ADRD programs to ensure cross-study
comparisons and facilitate access to HABS-HD data for these other initiatives.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HABS-HD - Project 3
-
批准号:10708902
-
项目类别:
-
资助金额:$52.41万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core E - Disparities & Outreach Core
-
批准号:10708877
-
项目类别:
-
资助金额:$73.67万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core F - Biostatistics Core
-
批准号:10708883
-
项目类别:
-
资助金额:$68.09万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core A - Admin Core
-
批准号:10708864
-
项目类别:
-
资助金额:$114.31万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core B - Neuroimaging & Informatics Core
-
批准号:10708866
-
项目类别:
-
资助金额:$185.8万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core G - Development Core
-
批准号:10708886
-
项目类别:
-
资助金额:$142.99万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core C - Clinical Core
-
批准号:10493847
-
项目类别:
-
资助金额:$1134.45万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Project 1
-
批准号:10708889
-
项目类别:
-
资助金额:$41.64万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core D - Omics Core
-
批准号:10708872
-
项目类别:
-
资助金额:$896.21万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Project 2
-
批准号:10708895
-
项目类别:
-
资助金额:$41.28万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
HABS-HD - Core C - Clinical Core
-
批准号:10708870
-
项目类别:
-
资助金额:$1154.5万
-
财政年份:2022
-
负责人:Sid E O'Bryant
-
依托单位:
Core E: Omics Core
-
批准号:10454256
-
项目类别:
-
资助金额:$312.05万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Project 3: Biomarkers for DS Clinical Trials
-
批准号:10037885
-
项目类别:
-
资助金额:$209.8万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Core E: Omics Core
-
批准号:10667582
-
项目类别:
-
资助金额:$320.31万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Project 3: Biomarkers for DS Clinical Trials
-
批准号:10667611
-
项目类别:
-
资助金额:$14.43万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Core E: Omics Core
-
批准号:10264839
-
项目类别:
-
资助金额:$324.8万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Project 3: Biomarkers for DS Clinical Trials
-
批准号:10264844
-
项目类别:
-
资助金额:$14.43万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Project 3: Biomarkers for DS Clinical Trials
-
批准号:10454261
-
项目类别:
-
资助金额:$14.43万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Core E: Omics Core
-
批准号:10037880
-
项目类别:
-
资助金额:$209.8万
-
财政年份:2020
-
负责人:Sid E O'Bryant
-
依托单位:
Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic Whites
-
批准号:10438941
-
项目类别:
-
资助金额:$76.77万
-
财政年份:2019
-
负责人:Sid E O'Bryant
-
依托单位:
海外基金