Actions for Collaborative Community Engaged Strategies for HPV (ACCESS HPV)

HPV 社区参与协作策略行动 (ACCESS HPV)

• 批准号: 10708926
• 负责人: OLIVER CHUKWUJEKWU EZECHI
• 金额: --
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2023-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10708926
• 关键词: AIDS prevention; Address; African; Age; Applications Grants; Area; Cancer Burden; Cancer Control; Cancerous; Caregivers; Cervical Cancer Screening; Clinic; Collection; Communities; Community Health Aides; Community Participation; Country; Daughter; Development; Dissemination and Implementation; Dose; Economic Models; Elements; Female; Goals; Government; Group Structure; HIV; Health Services Accessibility; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papillomavirus 6; Immunization Programs; Individual; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Learning; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical Research; Methods; Modeling; Morbidity - disease rate; Mothers; National Cancer Institute; Nigeria; Nigerian; Participant; Population; Prevention; Prevention strategy; Preventive measure; Primary Prevention; Problem Solving; Proctor framework; Quality-Adjusted Life Years; Randomized, Controlled Trials; Recommendation; Records; Research; Research Infrastructure; Resource-limited setting; Risk; Sampling; Secondary Prevention; Services; Specimen; State Government; Strategic Planning; Techniques; Time; United States; United States National Institutes of Health; Vaccination; Woman; Work; Youth; anticancer research; cancer prevention; cancer vaccination; community based participatory research; community clinic; community engagement; cost effectiveness; crowdsourcing; design; direct application; dissemination science; effectiveness evaluation; experience; experimental study; girls; health communication; implementation evaluation; implementation outcomes; implementation process; implementation research; implementation science; implementation strategy; improved; learning community; low and middle-income countries; mortality; mother-daughter relationship; older women; preference; premalignant; prevention service; primary outcome; programs; public health relevance; recruit; risk perception; scale up; screening; screening program; secondary outcome; self testing; social cognitive theory; treatment as usual; uptake; vaccine acceptance

ABSTRACT Cervical cancer is a major cause of morbidity and mortality in many sub-Saharan countries, including Nigeria. Expanding human papillomavirus (HPV) vaccination for young girls/women, ages 9-26 years (primary prevention) and HPV self-collection for cervical cancer screening for older women, ages 30-49 (secondary prevention) are both critical to achieving WHO and Nigerian goals for reducing the cervical cancer burden. The Nigerian government now recommends HPV vaccination and self-collection, yet uptake is poor. As such, context-specific, targeted and culturally relevant implementation strategies are needed. We focus on HPV vaccination among girls and self-collection among women because of the substantial burden of cervical cancer. Mother-daughter relationships in Nigeria can be leveraged to increase HPV vaccination uptake among young girls and HPV self-collection among mothers. Mothers (or similar female caregivers) profoundly influence decisions and preferences about young girls’ vaccine uptake in the Nigerian cultural context. At the same time, maternal choices about HPV self-collection can be reinforced in discussions with their daughters. In the proposed study, Actions for Collaborative Community-Engaged Strategies for HPV (ACCESS-HPV), we will use participatory crowdsourcing methods to drive HPV prevention among mother-daughter dyads. Crowdsourcing open calls will allow us to identify locally relevant messages and dissemination techniques to increase uptake of HPV prevention. Then, participatory learning communities will build capacity for community- led implementation of selected strategies. Informed by social learning theory and the PEN-3 cultural model, our multi-disciplinary research team proposes the following specific aims: (1) to develop a new combined campaign to increase HPV vaccination for young girls (ages 9-26) and HPV self-collection for mothers (ages 30-49) using crowdsourcing open calls and participatory learning communities; (2) to determine the effectiveness of a final combined campaign on uptake of HPV vaccination among young girls/women and HPV self-collection among their mothers using a stepped-wedge randomized controlled trial; (3) to estimate the impact and cost-effectiveness of the crowdsourced campaign. Our primary outcome will be vaccine uptake (ascertained by clinic records of vaccine uptake) among young girls and HPV self-collection (ascertained by laboratory receipt of specimens) among their mothers. The strong support of the Nigerian Institute for Medical Research (NIMR) alongside national HPV programs creates a rich research infrastructure and increases the likelihood of successful implementation. Our multi-disciplinary research team has experience organizing implementation research focused on crowdsourcing and community participation in Nigeria. This study will enhance our understanding of HPV prevention in resource-constrained settings. This grant application directly responds to strategic priorities of the United States government, the National Institutes of Health, the National Cancer Institute, and NOT-CA-20-025.

摘要