Core A: Administrative Core

项目摘要 由于未知的原因，德克萨斯州是美国肾癌发病率最高的州之一。德克萨斯大学西南 医疗中心(UTSW)及其附属机构、县医院、Parkland纪念医院(工作人员为 德克萨斯大学医学院)和德克萨斯卫生资源公司，为达拉斯要塞57%的新发肾癌患者提供服务 价值大都会。在加州大学西蒙斯综合癌症中心(SCCC)，肾癌排在第五位 常见肿瘤类型。2013年，肾癌计划(KCP)启动。得到了领导的认可 临床卓越计划奖和医疗保健Metroplex创新奖决赛入围者 一直是开拓者。由Brugarolas博士指导，目标是促进协作、跨学科 为了将UTSW的发现和技术创新转化为研究，KCP为 UTSW肾脏孢子，并作为其在UTSW/SCCC中整合的载体。作为协调中心 在孢子方面，行政核心提供必要的行政服务和组织支助，以 孢子作为一个整体。核心主任Brugarolas博士将继续提供总体指导和 科学领导，促进多学科互动，监督财政管理和报告。他的 科学背景、整个研究过程中的经验和管理角色使他能够 作为一个有效的整体孢子PI和行政核心主任。KCP和KCP联合领导人Kapur博士 之前孢子派的继任者，已经晋升为孢子皮和核心A联席董事。康纳奇-索雷尔博士， 代表不足的少数派和CEP的联合领导人也将作为共同领导人加入行政核心- 导演。由所有项目和核心的代表组成的执行委员会就以下事项提供咨询 孢子战略方向、部门和行政互动、教师招聘和资源 分配。代表癌症经验(来自当前患者)的患者权益倡导团队 癌症幸存者和照顾者)积极参与主要的社区和教育活动， 筹款，也许是最鼓舞人心的，在SCCC诊所志愿帮助其他患者。An内部 由机构领导人组成的咨询委员会充当听取意见的委员会，并担任外部咨询委员会 在各自领域拥有互补专业知识的领导者通过评估进展和提供投入来协助 未来的发展方向。KCP/孢子受益于UTSW和SCCC的坚定承诺 每家每年都承诺投入20万美元促进肾癌研究，从而扩大CEP的覆盖范围 和DRP计划，以及110万美元的招聘资金。核心A将继续通过以下方式实现其目标 目标有以下几点。目标1：与SCCC和UTSW合作推进肾脏卓越计划 癌症。目标2：服务和参与肾癌患者群体。目标3：推动最先进的 翻译肾癌研究计划。目标4：通过成功发展招募调查人员 研究和职业提升计划。目标5：支持和领导国家倡议。

Project Summary For reasons unknown, Texas has one of the highest incidence rates of kidney cancer in the US. UT Southwestern Medical Center (UTSW), together with its affiliates, the county hospital, Parkland Memorial Hospital (staffed by UTSW faculty), and Texas Health Resources, cares for 57% of all new kidney cancer patients in the Dallas-Fort Worth metroplex. At UTSW Simmons Comprehensive Cancer Center (SCCC), kidney cancer is the 5th most common tumor type. In 2013, the Kidney Cancer Program (KCP) was inaugurated. Recognized with a Leaders in Clinical Excellence Program Award and a finalist for the metroplex Innovation in Healthcare Award, the KCP has been a trailblazer. Directed by Dr. Brugarolas, and with the goal to promote collaborative, interdisciplinary research to translate discovery and technical innovation at UTSW, the KCP provides a foundation for the UTSW Kidney SPORE and serves as a vehicle for its integration within UTSW/SCCC. As the coordinating hub of the SPORE, the Administrative Core provides essential administrative services and organizational support to the SPORE as a whole. The Director of the Core, Dr. Brugarolas, will continue to provide overall direction and scientific leadership, promote multidisciplinary interactions, and oversee fiscal management and reporting. His scientific background, experience across the research continuum and administrative roles enable him to serve as an effective overall SPORE PI and Director of the Administrative Core. Dr. Kapur, Co-Leader of the KCP and previously SPORE PI successor, has been promoted to SPORE PI and Core A Co-Director. Dr. Conacci-Sorrell, an underrepresented minority and Co-Leader of the CEP, will also be joining the Administrative Core as Co- Director. An Executive Committee comprised of representatives from all Projects and Cores provides advice on SPORE strategic directions, departmental and administrative interactions, faculty recruitment, and resource allocation. A Patient Advocacy team representing the spectrum of the cancer experience (from current patients to cancer survivors and caregivers) is actively engaged in leading community and educational events, fundraising, and perhaps most inspiringly, volunteering at SCCC clinics to assist other patients. An Internal Advisory Board made up of institutional leaders serves as a sounding board, and an External Advisory Board of leaders in their fields with complementary expertise assists by evaluating progress and providing input on future directions. The KCP/SPORE benefits from a strong commitment from both UTSW and the SCCC with each committing $200,000 yearly to promote kidney cancer research, thereby extending the reach of the CEP and DRP programs, as well as $1,100,000 in recruitment funds. Core A will continue to fulfill its objectives through the following Aims. Aim 1: Partnering with the SCCC and UTSW to advance a program of excellence in kidney cancer. Aim 2: Serving and engaging the kidney cancer patient population. Aim 3: Furthering a state-of-the-art translational kidney cancer research program. Aim 4: Recruiting investigators through successful Developmental Research and Career Enhancement Programs. Aim 5: Supporting and leading national initiatives.