Developmental Research Program

发展研究计划

• 批准号: 10708855
• 负责人: James Brugarolas
• 金额: $ 20.66万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708855
• 关键词: Award; Budgets; Cancer Patient; Cellular biology; Clinical; Clinical Trials; Collaborations; Complement; Comprehensive Cancer Center; Dedications; Development; Electronic Mail; Ethnic Population; Faculty; Faculty Recruitment; Fostering; Foundations; Funding; Future; Grant; Hematology; Immune system; Institution; Internal Medicine; International; Kidney; Lead; Leadership; Letters; Medical center; Mentorship; Minority Groups; Mission; Nephrology; Oncology; Patient-Focused Outcomes; Peer Review; Physicians; Physiology; Preparation; Program Research Project Grants; Publications; Qualifying; Renal carcinoma; Reproduction spores; Research; Research Personnel; Research Project Grants; Resources; Scientific Advances and Accomplishments; Scientist; Selection Criteria; Texas; Translating; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Work; anticancer research; arm; cancer research center director; experience; high reward; improved; improved outcome; innovation; interest; meetings; member; mid-career faculty; multidisciplinary; novel therapeutics; professor; programs; racial population; recruit; research study; success; symposium; synergism; translational cancer research; translational impact; translational potential; trend; tumor

Project Summary The DRP provides seed funding for promising research projects with translational projection and potential to significantly impact kidney cancer research. The DRP funds pilot and/or high-impact/high-reward projects. It serves as a “pipeline” to support the mission of the SPORE. The DRP is led by Dr. Brugarolas, Professor of Internal Medicine/Hematology-Oncology and SPORE Director, together with Dr. Denise Marciano, Associate Professor of Nephrology and Cell Biology. Dr. Brugarolas brings to bear his expertise in renal cancer, and Dr. Marciano, a deep understanding of kidney physiology and cell biology. Their combined research experience, as well as their track record in program building and mentorship, provides them the expertise to successfully lead the DRP program. DRP proposals are solicited by Core A via a campus-wide email. Each submitted proposal is reviewed by at least 4 reviewers. Criteria for selection include significance, innovation, approach, investigator qualifications, and translational potential (or synergism with existing projects). Priority is given to proposals with the potential to become full SPORE projects. The highest-scoring proposals are funded following approval by the SPORE Executive Committee. DRP awardees have preferential use of SPORE Shared Core resources, and benefit from the expertise and leadership of SPORE investigators. They participate in SPORE conferences, where they regularly present their work. Metrics of success for DRP recipients include: invitations to present at scientific meetings; publication of original research studies; successful competition for independent external grant support; promotion of the projects to full SPORE projects; and, institutional recognition by promotion through the academic ranks. Over the 5 years of our SPORE, 16 DRP awards were funded. One DRP project set the foundation for SPORE Project 3 of the renewal application. For the next funding period, we seek to continue to attract and support a pipeline of diverse research interests and expertise relevant to kidney cancer, in particular from under-represented minority (URM) groups. These projects will enlarge the breadth and depth of innovative Kidney Cancer Program/SPORE translational research and serve as potential SPORE projects in the future. Enabling an expansion of the DRP/CEP, NCI/SPORE funding will be complemented by funds from Simmons Comprehensive Cancer Center (SCCC) and UTSW, providing $400,000/year. The DRP will aim to award 3 to 6 projects per year. The DRP will accomplish its mission through the following Aims. Aim 1. Expand translational kidney cancer research by providing seed funding for promising translational projects. Aim 2. Identify and recruit a pool of promising scientists and physician-scientists. Aim 3. Nurture the development and progress of the DRP projects and facilitate the transition of successful projects into competitive applications for peer-reviewed funding. Aim 4. Support SPORE DRP awardees to ensure that scientific advances are translated into improved outcomes for kidney cancer patients.

项目摘要 DRP为有前途的研究项目提供种子资金，这些项目具有转化预测和潜力， 对肾癌研究产生重大影响。减少灾害风险方案为试点项目和/或高影响/高回报项目提供资金。它 作为一个“管道”，以支持的使命的孢子。DRP由Brugarolas博士领导，教授 内科/血液肿瘤学和SPORE主任，以及助理Denise Marciano博士 肾脏学和细胞生物学教授。Brugarolas博士带来了他在肾癌方面的专业知识， Marciano，对肾脏生理学和细胞生物学的深刻理解。他们的综合研究经验， 以及他们在项目建设和指导方面的记录，为他们提供了成功领导的专业知识， DRP计划。DRP提案由核心A通过校园范围的电子邮件征求。每个提交的提案都是 至少有4名评审员。选择标准包括重要性、创新性、方法、研究者 资格和翻译潜力（或与现有项目的协同作用）。优先考虑的建议， 有潜力成为完整的SPORE项目。得分最高的提案在获得批准后获得资助， SPORE执行委员会。DRP获奖者优先使用SPORE共享核心资源，以及 从SPORE调查人员的专业知识和领导力中受益。他们参加SPORE会议， 他们定期展示他们的作品。DRP受助人的成功案例包括： 科学会议;发表原创性研究报告;成功竞争独立外部 赠款支持;将项目推广为完整的SPORE项目;以及通过推广获得机构认可 通过学术排名。在我们的SPORE的5年里，资助了16个DRP奖项。一个DRP项目 为续保申请的SPORE项目3奠定基础。在下一个资助期内，我们会 继续吸引和支持与肾癌相关的各种研究兴趣和专业知识， 特别是代表性不足少数群体。这些项目将扩大广度和深度 创新的肾癌项目/SPORE转化研究，并作为潜在的SPORE项目， 未来为了扩大DRP/CEP，NCI/SPORE的资金将得到以下资金的补充： 西蒙斯综合癌症中心（SCCC）和UTSW，每年提供40万美元。DRP将致力于 每年奖励3至6个项目。DRP将通过以下目标完成其使命。目标1.扩大 通过为有前途的转化项目提供种子资金，开展转化肾癌研究。目标2. 确定并招募一批有前途的科学家和医学科学家。目标3.培育发展， 的进展，并促进成功的项目过渡到竞争性的申请， 同行评审的资金。目标4。支持SPORE DRP获奖者，以确保科学进步得到转化 改善肾癌患者的预后。