Developmental Research Program

项目摘要 UTSW肾癌孢子基金发展研究计划(DRP)提供种子 为有希望的翻译项目提供资金，这些项目可能会对肾癌研究产生重大影响。民进党将 使用创新办法为试点和/或高影响/高风险项目提供资金，有可能产生 突破性的发现，以及对翻译的关注。DRP由孢子Brugarolas博士领导 主任兼项目4联合负责人门德尔博士。他们的研究以创新和翻译为特征， 在DRP项目中寻求的两个属性。将通过行政核心征求DRP建议；它们将 由DRP领导层对资格、适宜性和相关性进行预先筛选；由两名内部人员和一名人员审查 外部专家；并由孢子执行委员会批准提供资金。作为我们使命的一部分 为了增加多样性，建立了招募妇女和少数群体的机制。除了每年100,000美元 通过孢子赠款为DRP指定的UTSW，通过西蒙斯癌症中心，正在承诺 每年额外100,000美元，总计200,000美元，用于每年资助DRP项目。DRP将授予2-4个项目 每年(5年内共有15-20个项目)。评选标准包括：重要性、创新性、 方法、调查员资格和翻译潜力(或与现有项目的协同作用)。优先性 将给予有潜力成为全孢子项目的项目。DRP的具体目标是： 1)作为一种机制，为有前景的项目提供种子资金。2)确定和招募一批 有前途的科学家和内科科学家。3)促进发展和进步发展项目 以及将成功的项目转变为具有竞争力的同行审查资金申请。4)支持 孢子DRP奖获得者确保科学进步转化为改善肾脏的结果 癌症患者。DRP获奖者将充分利用孢子核心资源，将受益于专业知识和 孢子调查员的领导力(他们可以作为导师)，并将成为孢子调查员不可或缺的一部分 会议，在那里他们将定期介绍他们的工作。DRP收件人的成功衡量标准包括： 邀请在国内和国际科学会议上发言；成功竞争独立 国家卫生研究院赠款支持(特别是R01赠款)；出版受资助地区的原始研究报告；以及， 通过学术级别的提升获得机构认可。取得重大进展的DRP项目 对于他们的翻译目标来说，有可能被提升到全孢子项目。作为对一项 关于申请申请，收到了9份意向书，其中4份已展示。丰富多彩的 UTSW与肾癌相关的研究兴趣/专业知识流水线填充了动态DRP， 拓展孢子/肾癌计划研究的广度和深度。

Project Summary The Developmental Research Program (DRP) of the UTSW kidney cancer SPORE grant provides seed funding for promising translational projects that can significantly impact kidney cancer research. The DRP will fund pilot and/or high-impact/high-risk projects using innovative approaches, with the potential to generate groundbreaking discoveries, and a focus on translation. The DRP is led by Dr. Brugarolas, the SPORE Director, and Project 4 Co-Leader, Dr. Mendell. Their research is characterized by innovation and translation, two attributes sought in DRP projects. DRP proposals will be solicited via the Administrative Core; they will be prescreened for eligibility, suitability, and relevance by the DRP leadership; reviewed by two internal and one external expert; and approved for funding by the SPORE Executive Committee. As part of our mission to increase diversity, mechanisms are in place to recruit women and minorities. In addition to the $100,000/yr designated for the DRP through the SPORE grant, UTSW, via the Simmons Cancer Center, is committing an additional $100,000/yr for a total of $200,000 to fund DRP projects annually. The DRP will award 2-4 projects per year (a total of 15-20 projects over 5 years). Criteria for selection include: significance, innovation, approach, investigator qualifications, and translational potential (or synergism with existing projects). Priority will be given to projects with the potential to become full SPORE projects. The specific aims of the DRP are to: 1) Serve as a mechanism to provide seed funding for promising projects. 2) Identify and recruit a pool of promising scientists and physician-scientists. 3) Facilitate the development and progress of the DRP projects and the transition of successful projects into competitive applications for peer-reviewed funding. 4) Support SPORE DRP awardees to ensure that scientific advances are translated into improved outcomes for kidney cancer patients. DRP awardees will have full use of SPORE Core resources, will benefit from the expertise and leadership of the SPORE investigators (who may serve as mentors), and will be an integral part of SPORE meetings, where they will regularly present their work. Metrics of success for DRP recipients include: invitations to present at national and international scientific meetings; successful competition for independent NIH grant support (in particular R01 grants); publication of original research studies in the supported area; and, institutional recognition by promotion through the academic ranks. DRP projects that make significant progress towards their translational goals have the potential to be promoted to full SPORE projects. In response to a request for applications, 9 letters of intent were received including 4 that are showcased. A rich and diverse pipeline of research interests/expertise pertinent to kidney cancers at UTSW populates a dynamic DRP, expanding the breadth and depth of the SPORE/Kidney Cancer Program research.