Developmental Research Program

发展研究计划

• 批准号: 9071068
• 负责人: James Brugarolas
• 金额: $ 16.85万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071068
• 关键词: Antisense Oligonucleotides; Area; Augmented Reality; Award; Budgets; Cancer Center; Cancer Patient; Cancer Research Project; Clinical; Collaborations; Development; Dose; Eligibility Determination; Ensure; Evaluation; Fostering; Funding; Funding Agency; Goals; Grant; Human; Hypertension; IL2 gene; Immune; International; Leadership; Letters; Medical center; Mentors; Minority; Mission; Molecular; Mus; Nephrectomy; Operative Surgical Procedures; Outcome; Participant; Patients; Peer Review; Phase II Clinical Trials; Physicians; Preparation; Program Research Project Grants; Publications; Qualifying; Radiation; Raptors; Recruitment Activity; Renal carcinoma; Request for Applications; Research; Research Personnel; Resources; Robotics; Scientific Advances and Accomplishments; Scientist; Seeds; Selection Criteria; Signal Transduction; Source; Texas; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Woman; Work; anticancer research; biomarker identification; design; high risk; improved outcome; innovation; interest; meetings; multidisciplinary; programs; research study; response; success; synergism; tool; transcription factor; trend; tumor

Project Summary The Developmental Research Program (DRP) of the UTSW kidney cancer SPORE grant provides seed funding for promising translational projects that can significantly impact kidney cancer research. The DRP will fund pilot and/or high-impact/high-risk projects using innovative approaches, with the potential to generate groundbreaking discoveries, and a focus on translation. The DRP is led by Dr. Brugarolas, the SPORE Director, and Project 4 Co-Leader, Dr. Mendell. Their research is characterized by innovation and translation, two attributes sought in DRP projects. DRP proposals will be solicited via the Administrative Core; they will be prescreened for eligibility, suitability, and relevance by the DRP leadership; reviewed by two internal and one external expert; and approved for funding by the SPORE Executive Committee. As part of our mission to increase diversity, mechanisms are in place to recruit women and minorities. In addition to the $100,000/yr designated for the DRP through the SPORE grant, UTSW, via the Simmons Cancer Center, is committing an additional $100,000/yr for a total of $200,000 to fund DRP projects annually. The DRP will award 2-4 projects per year (a total of 15-20 projects over 5 years). Criteria for selection include: significance, innovation, approach, investigator qualifications, and translational potential (or synergism with existing projects). Priority will be given to projects with the potential to become full SPORE projects. The specific aims of the DRP are to: 1) Serve as a mechanism to provide seed funding for promising projects. 2) Identify and recruit a pool of promising scientists and physician-scientists. 3) Facilitate the development and progress of the DRP projects and the transition of successful projects into competitive applications for peer-reviewed funding. 4) Support SPORE DRP awardees to ensure that scientific advances are translated into improved outcomes for kidney cancer patients. DRP awardees will have full use of SPORE Core resources, will benefit from the expertise and leadership of the SPORE investigators (who may serve as mentors), and will be an integral part of SPORE meetings, where they will regularly present their work. Metrics of success for DRP recipients include: invitations to present at national and international scientific meetings; successful competition for independent NIH grant support (in particular R01 grants); publication of original research studies in the supported area; and, institutional recognition by promotion through the academic ranks. DRP projects that make significant progress towards their translational goals have the potential to be promoted to full SPORE projects. In response to a request for applications, 9 letters of intent were received including 4 that are showcased. A rich and diverse pipeline of research interests/expertise pertinent to kidney cancers at UTSW populates a dynamic DRP, expanding the breadth and depth of the SPORE/Kidney Cancer Program research.

项目摘要 UTSW肾癌SPORE赠款的发展研究计划（DRP）提供种子 资助有前途的转化项目，可以显着影响肾癌研究。DRP将 利用创新办法资助试点和/或影响力大/风险高的项目， 突破性的发现，以及对翻译的关注。DRP由Brugarolas博士领导， 项目4共同负责人Mendell博士他们的研究特点是创新和翻译， DRP项目中寻求的两个属性。DRP提案将通过行政核心征求;它们将 由DRP领导层对合格性、适用性和相关性进行预先筛选;由两名内部人员和一名内部人员进行审查 外部专家;并由SPORE执行委员会批准资助。作为我们使命的一部分， 为了增加多样性，建立了征聘妇女和少数民族的机制。除了10万美元/年 通过SPORE赠款指定为DRP，UTSW通过西蒙斯癌症中心正在承诺 每年增加100，000美元，共计200，000美元，用于资助DRP项目。DRP将授予2-4个项目 （5年内共15-20个项目）。评选标准包括：重要性、创新性、 方法、研究者资格和翻译潜力（或与现有项目的协同作用）。优先 将给予有潜力成为完整SPORE项目的项目。《残疾人权利方案》的具体目标是： 1)作为一种机制，为有希望的项目提供种子资金。2)确定并招募一批 有前途的科学家和医学科学家。3)促进减少灾害风险方案项目的发展和进展 以及将成功的项目转化为竞争性的同行评审资金申请。4)支持 SPORE DRP获奖者确保将科学进步转化为改善肾脏的结果 癌症患者。DRP获奖者将充分利用SPORE核心资源，将受益于专业知识， 领导SPORE调查人员（可能担任导师），并将成为SPORE不可分割的一部分 他们将定期在会议上介绍他们的工作。DRP受助人的成功案例包括： 应邀出席国家和国际科学会议;成功竞争独立 NIH赠款支持（特别是R 01赠款）;在支持领域发表原创研究;以及， 透过学术职级晋升而获得院校认可。取得重大进展的DRP项目 有可能被提升为完整的SPORE项目。响应于 在申请过程中，共收到9份意向书，其中4份已展示。丰富多样的 UTSW与肾癌相关的研究兴趣/专业知识管道构成了动态DRP， 扩大孢子/肾癌项目研究的广度和深度。