Core A: Administrative Core

项目摘要 这一核心将为UTSW肾癌孢子提供必要的行政服务和支持。 国际和平协会，布鲁加罗拉斯博士，非常适合提供总体指导，促进互动，提供科学 领导，并监督这项复杂拨款的财政管理。他的科学背景，历史 参与翻译科学的许多方面，以及目前在UTSW的管理角色(包括 肾癌计划(KCP)负责人和国家癌症研究所指定的科学领导成员， 现在全面，西蒙斯癌症中心)使他非常有资格担任总体PI和核心 导演。他得到了Core A联席董事Sagalowsky博士(泌尿外科教授和KCP)的帮助 泌尿外科联合负责人)和McKay博士(KCP研究管理主任)，以及一流的行政管理人员 一队。执行委员会(项目负责人和核心主管)为规划提供建议 孢子战略方向，与部门和行政部门的互动，教师招聘，以及 资源配置。KCP和孢子在癌症中心内很好地整合在一起，并从许多 共享资源。机构承诺体现为：(I)参加未偿还的内部审计委员会 调查人员和机构领导人，以及(2)重大财政承诺，包括#年1,100,000美元 每年为主要研究人员及其实验室的工资、福利和运营费用提供直接支持；以及 年度经常性资金：150,000美元(用于匹配CEP和DRP)，150,000美元(用于支持数据分析核心)， 和50,000美元(可自由支配的基金)。此外，还将提供110万美元的征聘资金。这个 孢子包括一个由积极参与的个人组成的充满活力的患者倡导团队，他们广泛参与了 KCP，包括筹款、提高认识和社会活动。我们杰出的EAB包括 他们的领域在临床/翻译研究方面具有互补的专业知识(Arteaga，George，Michaelson， Nelson，oh，Ratain和Shyr)，流行病学研究(Heng和Shyr)，以及基础研究(Simon)。这个 核心A的目标是直截了当的，应该能够实现组织复杂的互动网络的目标 涉及众多调查人员、工作人员、核心人员和倡导者：(1)监督和指导所有科学和 孢子的行政方面，包括研究/数据管理、财政监督和遵守， 和传播方面：(A)监督和保持孢子的科学性和严谨性；(B)记录， 监测和监督所有预算项目；(C)监测和确保孢子遵守情况的所有方面： NCI法规和要求，并与NCI项目官员(和其他工作人员)沟通以确保 遵守报告；(D)安排和组织所有会议，包括与咨询委员会的会议 董事会和患者权益倡导者。(2)监督和协调发展研究计划和 职业提升计划，提供财政、组织和外展支持。(三)协调配合 监督患者代言人计划活动。(4)监督和促进科学争议的解决。

Project Summary This core will provide essential administrative services and support for the UTSW Kidney Cancer SPORE. The PI, Dr. Brugarolas, is well-suited to provide overall direction, facilitate interactions, provide scientific leadership, and oversee the fiscal management of this complex grant. His scientific background, history of participation in many aspects of translational science, and current administrative roles at UTSW (including Leader of the Kidney Cancer Program (KCP) and member of the scientific leadership of the NCI-designated, now comprehensive, Simmons Cancer Center) make him well-qualified to serve as overall PI and Core Director. He is aided by Core A Co-Directors, Dr. Sagalowsky (Professor of Urology and Surgery, and a KCP Urology co-Leader), and Dr. McKay (KCP Director of Research Administration), and a first-rate administrative team. An Executive Committee (Project Leaders and Core Directors) provides advice for the planning of SPORE strategic directions, interactions with departments and administration, faculty recruitment, and resource allocation. The KCP and SPORE are well-integrated within the Cancer Center and benefit from many shared resources. Institutional commitment is illustrated by (i) participation in the IAB of outstanding investigators and institutional leaders, and (ii) a significant financial commitment, including $1,100,000 in annual direct support for salaries, benefits and operating costs of key investigators and their laboratories, and recurring annual funds of: $150,000 (to match CEP and DRP), $150,000 (to support the Data Analytics Core), and $50,000 (discretionary funds). In addition, $1,100,000 in recruitment funds will be made available. The SPORE includes a dynamic patient advocacy team of engaged individuals who have participated extensively in the KCP, including fundraising, raising awareness, and social events. Our outstanding EAB includes leaders in their fields with complementary expertise in clinical/translational research (Arteaga, George, Michaelson, Nelson, Oh, Ratain, and Shyr), epidemiological research (Heng and Shyr), and basic research (Simon). The Core A aims are straightforward and should fulfill the objective of organizing a complex network of interactions involving numerous investigators, staff, cores, and advocates: (1) Oversee and direct all scientific and administrative aspects of the SPORE including research/data management, fiscal oversight and adherence, and communication aspects: (a) Oversee and maintain scientific quality and rigor of the SPORE; (b) Record, monitor, and oversee all budgetary items; (c) Monitor and ensure all aspects of SPORE compliance following NCI regulations and requirements, and communicate with NCI Program Officer (and other staff) to ensure compliance with reporting; (d) Schedule and organize all meetings, including meetings with the Advisory Boards, and Patient Advocates. (2) Oversee and coordinate with the Developmental Research Program and the Career Enhancement Program to provide fiscal, organizational, and outreach support. (3) Coordinate and oversee Patient Advocate Program activities. (4) Oversee and facilitate resolution of scientific disputes.