Core A: Administrative Core

项目摘要 该核心将为UTSW肾癌孢子提供必要的行政服务和支持。 主要研究者Brugarolas博士非常适合提供总体指导，促进互动，提供科学的 领导，并监督这一复杂赠款的财政管理。他的科学背景， 参与翻译科学的许多方面，以及目前在UTSW的行政职务（包括 肾癌项目（KCP）的负责人和NCI指定的科学领导成员， 西蒙斯癌症中心）使他完全有资格担任整体PI和核心 导演他由核心A共同主任Sagalowsky博士（泌尿外科教授和KCP）协助 泌尿科共同负责人）和McKay博士（KCP研究管理主任），以及一流的行政管理人员。 团队一个执行委员会（项目领导人和核心主任）为规划 SPORE的战略方向，与部门和管理，教师招聘，和 资源配置KCP和SPORE在癌症中心内得到了很好的整合， 共享资源。机构承诺体现在：（一）参加国际咨询委员会的杰出代表 调查员和机构领导人，以及㈡大量的财政承诺，包括1，100，000美元， 每年直接支助主要研究人员及其实验室的薪金、福利和业务费用，以及 经常性年度资金：150，000美元（用于匹配CEP和DRP），150，000美元（用于支持数据分析核心）， 50,000元（自由支配资金）。此外，还将提供1 100 000美元的征聘资金。的 SPORE包括一个充满活力的患者倡导团队，由广泛参与以下活动的个人组成： KCP，包括筹款，提高认识和社会活动。我们杰出的EAB包括以下领域的领导者： 他们的领域与临床/转化研究的互补专业知识（Arteaga，乔治，Michaelson， 纳尔逊，哦，Ratain和Shyr），流行病学研究（Heng和Shyr），和基础研究（Simon）。的 核心A目标是直截了当的，应该实现组织一个复杂的互动网络的目标 涉及众多研究人员，工作人员，核心和倡导者：（1）监督和指导所有科学和 SPORE的行政方面，包括研究/数据管理、财政监督和遵守， 和沟通方面：（a）监督和保持SPORE的科学质量和严谨性;（B）记录， 监控和监督所有预算项目;（c）监控和确保SPORE遵守以下各项的所有方面 NCI法规和要求，并与NCI项目官员（和其他工作人员）沟通，以确保 （d）安排和组织所有会议，包括与咨询委员会的会议 董事会和患者律师。(2)监督和协调发展研究计划， 职业提升计划，提供财政、组织和外展支持。(3)协调和 监督患者倡导计划活动。(4)监督和促进科学争议的解决。

Project Summary This core will provide essential administrative services and support for the UTSW Kidney Cancer SPORE. The PI, Dr. Brugarolas, is well-suited to provide overall direction, facilitate interactions, provide scientific leadership, and oversee the fiscal management of this complex grant. His scientific background, history of participation in many aspects of translational science, and current administrative roles at UTSW (including Leader of the Kidney Cancer Program (KCP) and member of the scientific leadership of the NCI-designated, now comprehensive, Simmons Cancer Center) make him well-qualified to serve as overall PI and Core Director. He is aided by Core A Co-Directors, Dr. Sagalowsky (Professor of Urology and Surgery, and a KCP Urology co-Leader), and Dr. McKay (KCP Director of Research Administration), and a first-rate administrative team. An Executive Committee (Project Leaders and Core Directors) provides advice for the planning of SPORE strategic directions, interactions with departments and administration, faculty recruitment, and resource allocation. The KCP and SPORE are well-integrated within the Cancer Center and benefit from many shared resources. Institutional commitment is illustrated by (i) participation in the IAB of outstanding investigators and institutional leaders, and (ii) a significant financial commitment, including $1,100,000 in annual direct support for salaries, benefits and operating costs of key investigators and their laboratories, and recurring annual funds of: $150,000 (to match CEP and DRP), $150,000 (to support the Data Analytics Core), and $50,000 (discretionary funds). In addition, $1,100,000 in recruitment funds will be made available. The SPORE includes a dynamic patient advocacy team of engaged individuals who have participated extensively in the KCP, including fundraising, raising awareness, and social events. Our outstanding EAB includes leaders in their fields with complementary expertise in clinical/translational research (Arteaga, George, Michaelson, Nelson, Oh, Ratain, and Shyr), epidemiological research (Heng and Shyr), and basic research (Simon). The Core A aims are straightforward and should fulfill the objective of organizing a complex network of interactions involving numerous investigators, staff, cores, and advocates: (1) Oversee and direct all scientific and administrative aspects of the SPORE including research/data management, fiscal oversight and adherence, and communication aspects: (a) Oversee and maintain scientific quality and rigor of the SPORE; (b) Record, monitor, and oversee all budgetary items; (c) Monitor and ensure all aspects of SPORE compliance following NCI regulations and requirements, and communicate with NCI Program Officer (and other staff) to ensure compliance with reporting; (d) Schedule and organize all meetings, including meetings with the Advisory Boards, and Patient Advocates. (2) Oversee and coordinate with the Developmental Research Program and the Career Enhancement Program to provide fiscal, organizational, and outreach support. (3) Coordinate and oversee Patient Advocate Program activities. (4) Oversee and facilitate resolution of scientific disputes.