Time Domain Description of Polysomnography Data

多导睡眠图数据的时域描述

• 批准号: 6833108
• 负责人: JACK R. SMITH
• 金额: $ 37.5万
• 依托单位: NEUROTRONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833108
• 关键词: clinical research; computer data analysis; computer graphics /printing; computer system design /evaluation; data collection methodology /evaluation; data management; human data; polysomnography; time resolved data

DESCRIPTION (provided by applicant): Polysomnography, the advent in the 1950s of an objective means of recording and analyzing sleep, greatly accelerated progress in the scientific description of sleep, including the establishment of age-sex norms. In the 1980s, polysomnography enabled the discovery and description of obstructive sleep apnea, a relatively common condition having co-morbidities such as hypertension, stroke, diabetes, epilepsy, and possibly some variants of Alzheimer's Disease, as well as detrimental effects on waking cognitive function and mood. During the past two decades, the marriage of relatively inexpensive desktop computers to polysomnography has spawned the field of digital polysomnography, replacing the large, cumbersome, data acquisition and display-limited analog polysomnographs by desktop digital systems enabling data acquisition, display, autoscoring, report generation, and archival of polysomnographic data. While providing advantages in terms of the ease and flexibility of data display, monitoring, and reporting of polysomnography data, digital polysomnography provides a decreased accuracy of the data representation/analysis and its display on the industry-standard 30 second computer monitor. The proposed work offers the possibility of a third paradigmatic advance in the objective description of polysomnographic data-development of an originally-conceived, fully customizable, time domain-based software system that provides accurate representation and analysis of the micro-architecture of polysomnography data. The system also provides a fully customizable technique for enhancing the ocular discrimination of waveforms on the industry-standard 30 second computer monitor screen, and customizable modules for reporting and archiving of the microarchitecture of sleep waveforms. Phase I successfully accomplished development of the system's time domain-based waveform analysis tools for delta wave activity, as well as for the display, report generation, and archival of delta waveforms. Phase II work will extend the Phase I work to all of the waveforms of human adult sleep. The work will continue the development of the display enhancement tool for enhancing the ocular discrimination of sleep waveforms on a computer monitor, of additional GUIs to facilitate user inputs and provide multiple means for obtaining the processed data, and of the database management system and report generation modules. The work will be validated by bench testing and a sleep lab study. An enormous commercial potential is anticipated.

描述(由申请人提供)： 多导睡眠图是20世纪50年代出现的一种客观的记录和分析睡眠的方法，极大地促进了对睡眠的科学描述，包括建立年龄-性别标准。在20世纪80年代，多导睡眠图使人们能够发现和描述阻塞性睡眠呼吸暂停，这是一种相对常见的疾病，具有高血压、中风、糖尿病、癫痫等共病症状，可能还有阿尔茨海默病的一些变种，以及对清醒的认知功能和情绪的不利影响。在过去的二十年里，相对便宜的台式计算机与多导睡眠图的结合催生了数字多导睡眠图领域，用能够实现数据采集、显示、自动搜索、报告生成和多导睡眠图数据存档的台式数字系统取代了大型、繁琐的数据采集和显示受限的模拟多导睡眠图。虽然数字多导睡眠图在数据显示、监测和报告多导睡眠图数据的简便性和灵活性方面具有优势，但它降低了数据表示/分析及其在行业标准30秒计算机监视器上显示的准确性。 拟议的工作为多导睡眠图数据的客观描述提供了第三个范式进步的可能性--开发一种最初构思的、完全可定制的、基于时间域的软件系统，该软件系统提供对多导睡眠图数据的微结构的准确表示和分析。该系统还提供了一种完全可定制的技术，用于增强行业标准30秒计算机监视器屏幕上的波形的肉眼辨别能力，以及用于报告和存档睡眠波形微体系结构的可定制模块。第一阶段成功地完成了系统基于时间域的波形分析工具的开发，用于三角洲波活动以及三角洲波形的显示、报告生成和存档。第二阶段的工作将把第一阶段的工作扩展到人类成年睡眠的所有波形。这项工作将继续开发显示增强工具，以增强计算机监视器上睡眠波形的目视辨别能力，开发更多的图形用户界面，以方便用户输入并提供获得处理后数据的多种手段，以及开发数据库管理系统和报告生成模块。这项工作将通过台架测试和睡眠实验室研究来验证。预计会有巨大的商业潜力。