Pediatric Polysomnography

儿科多导睡眠图

• 批准号: 7023855
• 负责人: JACK R. SMITH
• 金额: $ 37.01万
• 依托单位: NEUROTRONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-11-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7023855
• 关键词: biomedical automation; clinical research; computer data analysis; computer graphics /printing; computer program /software; computer system design /evaluation; computer system hardware; human data; online computer; patient monitoring device; pediatrics; polysomnography; sleep; sleep disorders

DESCRIPTION (provided by applicant): Polysomnography, the advent in the 1950s of an objective means of recording and analyzing sleep, greatly accelerated progress in the scientific description of sleep, including the establishment of age-sex norms. In the 1980s, polysomnography enabled the discovery and description of obstructive sleep apnea, a relatively common condition having co-morbidities such as hypertension, stroke, diabetes, epilepsy, and possibly some variants of Alzheimer's disease, as well as detrimental effects on waking cognitive function and mood. During the past two decades, the marriage of relatively inexpensive desktop computers to polysomnography has spawned the field of digital/computerized polysomnography (cPSG). While cPSG has offered indubitable advantages over its analog predecessor in terms of the flexibility and ease of data display and editing, as well as in space requirements and cost of data archival, cPSG provides a decreased accuracy of its data representation/analysis and display on the 30 second computer monitor screen. The proposed work offers the possibility of a third paradigmatic advance in polysomnography-an originally conceived software system that builds upon technological advances of the past decade in computer hardware and software, enabling accurate representation, display, analysis, report generation, and archival of the core dynamic sleep waves and waveforms of children's (and adults') sleep, while maintaining capability of providing traditionally computed "sleep architecture" macroparameters for pediatric and adult sleep. Our completed Phase I work successfully performed bench work development and validation of the system's foundational waveform detection and analysis tools for the accurate representation, display, and analysis of the delta waves of pediatric sleep. The Phase II work will extend this development to all of the primary waves and waveforms of pediatric sleep, additionally scaffolding the development to a tool permitting accessing of PSG data from multiple hardware platforms and in multiple data formats, and to a powerful but relatively inexpensive database management module offering customized data archival. The innovative system development will be validated by bench testing and by a sleep lab validation study of its automated analysis capability. The system's capabilities far exceed the capabilities offered by commercially available systems, auguring an enormous commercial potential.

描述（由申请人提供）：多导睡眠图，在20世纪50年代出现的记录和分析睡眠的客观手段，大大加快了睡眠的科学描述，包括年龄性别规范的建立。在20世纪80年代，多导睡眠描记术使阻塞性睡眠呼吸暂停的发现和描述成为可能，阻塞性睡眠呼吸暂停是一种相对常见的病症，具有诸如高血压、中风、糖尿病、癫痫和可能的阿尔茨海默病的一些变体的共病，以及对清醒的认知功能和情绪的有害影响。在过去的二十年中，相对便宜的台式计算机与多导睡眠图的结合催生了数字/计算机化多导睡眠图（cPSG）领域。虽然cPSG在数据显示和编辑的灵活性和简易性以及数据存档的空间要求和成本方面提供了与其模拟前身相比的毋庸置疑的优势，但cPSG在30秒计算机监视器屏幕上提供了其数据表示/分析和显示的准确性降低。拟议的工作提供了多导睡眠图第三个范式进步的可能性-一个最初设想的软件系统，建立在过去十年的计算机硬件和软件技术进步的基础上，能够准确地表示，显示，分析，报告生成和存档的核心动态睡眠波和儿童睡眠的波形。（和成人的）睡眠，同时保持提供用于小儿和成人睡眠的传统计算的“睡眠结构”宏参数的能力。我们完成的第一阶段工作成功地进行了系统基础波形检测和分析工具的实验室工作开发和验证，以准确表示，显示和分析儿科睡眠的δ波。第二阶段的工作将扩展到所有的主要波和小儿睡眠波形的发展，另外脚手架的发展，允许访问PSG数据从多个硬件平台和多种数据格式的工具，并提供定制的数据存档功能强大，但相对便宜的数据库管理模块。创新系统开发将通过台架测试和睡眠实验室对其自动分析能力的验证研究进行验证。该系统的能力远远超过了商业上可用的系统所提供的能力，预示着巨大的商业潜力。