Neural control of renin expression by microRNA in hypertension

高血压中 microRNA 对肾素表达的神经控制

• 批准号: nhmrc : GNT1104528
• 负责人: Dr Francine Marques
• 金额: $ 80.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neural-control-renin-microrna-hypertension/1346366
• 关键词: Neural; control; renin; expression; microRNA

We identified that mice bred to have high blood pressure have an overactive nervous system that affects a gene that controls a hormone in the kidney that increases blood pressure. The proposal will determine the effects of a novel treatment to alter the gene to reverse the changes in the kidney and thereby normalizing blood pressure. This will lead to new therapy and reduce the major risk factor of cardiovascular disease.

我们发现，被培育出患有高血压的老鼠的神经系统过于活跃，影响了一种控制肾脏中一种激素的基因，这种激素会增加血压。该提案将确定一种新的治疗方法的效果，通过改变基因来逆转肾脏的变化，从而使血压正常化。这将导致新的治疗方法，并减少心血管疾病的主要危险因素。