NUMERICAL SIMULATION OF SHOCKWAVE LITHOTRIPSY

冲击波碎石术的数值模拟

• 批准号: 6891517
• 负责人: TIM COLONIUS
• 金额: $ 17.95万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891517
• 关键词: biomechanics; biomedical equipment development; biophysics; cellular pathology; computer simulation; extracorporeal circulation; imaging /visualization /scanning; kidney function; lithotripsy; luminescence; mathematical model; mechanical pressure; mechanical stress; model design /development; nephrolithiasis; sound frequency; tissue /cell culture; ultrasonography; ultrasound biological effect

Research in SWL conducted over the past ten years has shown that stresses sufficient to induce both fragmentation and cellular-level tissue damage can result from direct interaction with the focusing shockwave as well as secondary stresses induced by the expansion and collapse of cavitation bubbles. The proposed research will provide a detailed modeling and simulation of the fluid and solid-dynamical processes that occur both in vitro and in vivo during SWL. The specific aims are: 1. Modeling and computer simulation of the stresses acting on stones and soft tissue that results from the focusing shockwaves and clouds of cavitations bubbles in the fluid state. 2. Computer simulation of the dynamic fracture and fragmentation process in realistic stone models, including tracking the origin and propagation of each fracture. 3. Quantitative assessment of soft tissue damage in anatomically correct finite element models kidneys and individual structures therein. The modeling effort is closely guided by the extent and nature of the experimental evidence, available from close collaboration with the Program Project Group, that can be used to calibrate and validate the models. These data include quantitative assessment of kidney geometry and damage through digital images from a computer segmentation of pig kidneys, detailed pressure hydrophone measurements in vitro and in vivo, ultra-high-speed photography of bubble clouds and shockwaves, data on stone fragmentation, mechanical testing of strain-rate dependent material behavior, and ultrasound tomography of the structure and fracture of stones. Impact on clinical application will be maximized by working toward an integrated simulation facility capable of full-scale analysis of anatomically and mechanically correct models of stone comminution and tissue injury. The simulation facility will allow unprecedented predictive power that may ultimately show how to pulverize stones with fewer shocks and less renal injury.

在过去十年中进行的SWL研究表明，应力足以引起破碎和细胞水平的组织损伤，可以导致与聚焦冲击波的直接相互作用，以及由空化气泡的膨胀和破裂引起的二次应力。 拟议的研究将提供一个详细的建模和模拟的流体和固体动力学过程中发生在体外和体内SWL。具体目标是： 1.作用在结石和软组织上的应力的建模和计算机模拟，这些应力来自于流体状态下的聚焦冲击波和空化气泡云。 2.计算机模拟真实岩石模型中的动态断裂和破碎过程，包括跟踪每个断裂的起源和传播。 3.在解剖学上正确的有限元模型中定量评估软组织损伤，肾脏和其中的单个结构。 建模工作由实验证据的范围和性质密切指导，可通过与计划项目组的密切合作获得，可用于校准和验证模型。这些数据包括通过计算机分割猪肾的数字图像定量评估肾脏几何形状和损伤，体外和体内详细的压力水听器测量，气泡云和冲击波的超高速摄影，结石破碎数据，应变率相关材料行为的机械测试，以及结石结构和断裂的超声断层扫描。对临床应用的影响将最大限度地努力向一个综合的模拟设施，能够全面分析的解剖和机械正确的模型，石头粉碎和组织损伤。该模拟设备将提供前所未有的预测能力，最终可能显示如何以更少的电击和更少的肾损伤来治疗结石。