Synergy of Inverse Scatter & Vibro-Acoustics

描述（由申请人提供）： 第一阶段SBIR赠款申请的目的是建立一个实验室可行性，乳腺癌成像系统，证明了振动声发射（VAE）技术与先进的超声反射断层扫描（URT）和定量超声逆散射断层扫描（UIST）相结合的协同效益。将在马约诊所工作的VAE成像子系统的副本添加到TSI工作的URT和UIST成像子系统中。这种新的混合系统将首先使用圆柱形和3D拟人乳房测试对象（phantomorphic）进行测试，这些测试对象包含模拟良性和癌性病变以及模拟良性和癌性组织的微钙化（MC）模式，如原位延性癌（DCIS）和小叶癌（LC）。作为I期可行性研究的一部分，第二级测试将在试点研究中使用至少3名志愿者，以确定VAE与UIST和URT成像模式相结合的优势。VAE对MC的敏感性将与URT和UIST对软组织特性的高分辨率、敏感性和特异性相结合。这些志愿者将从MC乳房X线照片阳性的人群中选择，包括与可能的良性、可能的DCIS和可能的LC相关的乳房X线照片。试点研究的规模较小，反映了在受控实验室环境中使用用于检测MC的工作敏感设备与尽快在人类受试者中测试该设备之间的折衷。第二阶段的工作将增加改进的电子设备;更高的扫描速度，更准确的成像和更大的临床研究。

DESCRIPTION (provided by applicant): The objective of this Phase I SBIR grant application us to build a laboratory feasibility, breast cancer imaging system, that demonstrates synergistic benefits of combining Vibro-Acoustic Emission (VAE) technology with advanced Ultrasound Reflection Tomography (URT) and quantitative Ultrasound Inverse Scattering Tomography (UIST). A duplicate of a VAE imaging subsystem working at Mayo Clinic will be added to a working URT and UIST imaging subsystem at TSI. This new hybrid system will first be tested with cylindrical and 3-D anthropomorphic breast test objects (phantoms) that contain simulated benign and cancerous lesions and Micro Calcifications (MC) in patterns, which simulate benign and cancerous tissues, such a Ductile Carcinoma In Situ (DCIS) and Lobular Carcinoma (LC). As part of the Phase I feasibility study, a second level of testing will use at least 3 volunteers in a pilot study to determine the advantages of combining VAE with UIST and URT imaging modes. The sensitivity of VAE to MC will be combined with the high resolution, sensitivity and specificity of URT and UIST to soft tissue properties. These volunteers will be selected from a population with positive mammograms for MC that includes mammograms associated with probable benign, probable DCIS and probable LC. The small size of the pilot study reflects a compromise between using working sensitive equipment built for detecting MC in a controlled laboratory environment with testing this equipment as soon as possible on human subjects. Phase II work will add improved electronics; higher scan speed, more accurate imaging and a larger clinical study.