Synergy of Inverse Scatter & Vibro-Acoustics

逆散射的协同作用

• 批准号: 6741374
• 负责人: Steven Abbott Johnson
• 金额: $ 10万
• 依托单位: TECHNISCAN, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-17 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741374
• 关键词: bioimaging /biomedical imaging; breast neoplasms; clinical research; human subject; imaging /visualization /scanning; mammography; optics; otoacoustic emission; phantom model; radiography; radiology; technology /technique development

DESCRIPTION (provided by applicant): The objective of this Phase I SBIR grant application us to build a laboratory feasibility, breast cancer imaging system, that demonstrates synergistic benefits of combining Vibro-Acoustic Emission (VAE) technology with advanced Ultrasound Reflection Tomography (URT) and quantitative Ultrasound Inverse Scattering Tomography (UIST). A duplicate of a VAE imaging subsystem working at Mayo Clinic will be added to a working URT and UIST imaging subsystem at TSI. This new hybrid system will first be tested with cylindrical and 3-D anthropomorphic breast test objects (phantoms) that contain simulated benign and cancerous lesions and Micro Calcifications (MC) in patterns, which simulate benign and cancerous tissues, such a Ductile Carcinoma In Situ (DCIS) and Lobular Carcinoma (LC). As part of the Phase I feasibility study, a second level of testing will use at least 3 volunteers in a pilot study to determine the advantages of combining VAE with UIST and URT imaging modes. The sensitivity of VAE to MC will be combined with the high resolution, sensitivity and specificity of URT and UIST to soft tissue properties. These volunteers will be selected from a population with positive mammograms for MC that includes mammograms associated with probable benign, probable DCIS and probable LC. The small size of the pilot study reflects a compromise between using working sensitive equipment built for detecting MC in a controlled laboratory environment with testing this equipment as soon as possible on human subjects. Phase II work will add improved electronics; higher scan speed, more accurate imaging and a larger clinical study.

描述（由申请人提供）： 第一阶段 SBIR 资助申请的目标是建立一个实验室可行性的乳腺癌成像系统，该系统展示了振动声发射 (VAE) 技术与先进的超声反射断层扫描 (URT) 和定量超声反散射断层扫描 (UIST) 相结合的协同效益。 Mayo Clinic 工作的 VAE 成像子系统的副本将添加到 TSI 工作的 URT 和 UIST 成像子系统中。这种新的混合系统将首先使用圆柱形和 3D 拟人乳房测试物体（体模）进行测试，其中包含模拟良性和癌性病变以及微钙化 (MC) 图案，模拟良性和癌性组织，如延性原位癌 (DCIS) 和小叶癌 (LC)。作为第一阶段可行性研究的一部分，第二级测试将在试点研究中使用至少 3 名志愿者，以确定 VAE 与 UIST 和 URT 成像模式相结合的优势。 VAE 对 MC 的敏感性将与 URT 和 UIST 对软组织特性的高分辨率、敏感性和特异性相结合。这些志愿者将从 MC 乳房 X 光检查呈阳性的人群中选出，其中包括与可能良性、可能 DCIS 和可能 LC 相关的乳房 X 光检查。试点研究的规模较小，反映出在受控实验室环境中使用用于检测 MC 的工作敏感设备与尽快在人体上测试该设备之间的折衷。第二阶段工作将增加改进的电子设备；更高的扫描速度、更准确的成像和更大规模的临床研究。