Thermoacoustic and Inverse Scattering Breast Cancer Scanner

热声和逆散射乳腺癌扫描仪

• 批准号: 7156135
• 负责人: Steven Abbott Johnson
• 金额: $ 11.95万
• 依托单位: TECHNISCAN, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156135
• 关键词: Acoustics; Algorithms; Benign; Biopsy; Breast Cancer Detection; Cancer Detection; Clinical; Complex; Computer Simulation; Data; Diagnosis; Diagnostic; Diagnostic Specificity; Discrimination; Electric Conductivity; Fever; Fibroadenoma; Financial compensation; Generations; Heating; Hybrids; Image; Imaging technology; Laboratories; Malignant Neoplasms; Mammography; Medical; Methods; Modality; Modeling; Morphologic artifacts; Multimodal Imaging; Phase; Range; Research; Resolution; Scanning; Schedule; Screening procedure; Sensitivity and Specificity; Simulate; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Specificity; Speed; Staging; Standards of Weights and Measures; System; Techniques; Testing; Three-Dimensional Imaging; Tissues; Ultrasonography; Validation; Woman; absorption; abstracting; attenuation; breast cancer diagnosis; cancer diagnosis; cost; electric impedance; falls; hyperthermia treatment; improved; malignant breast neoplasm; novel; research study; simulation; sound; tomography

DESCRIPTION (provided by applicant): Thermoacoustic and Inverse Scattering Breast Cancer Scanner ABSTRACT: We propose a novel, hybrid, imaging system for breast cancer diagnosis that exploits the elevated electrical conductivity. This system combines three advanced ultrasound- imaging methods with thermoacoustic imaging. The new ultrasound imaging methods are: (1) a reflection ultrasound tomography modality (images acoustic impedance gradients); (2,) an ultrasound inverse scattering modality that image absolute speed of sound); (3) an ultrasound inverse scattering modality that images absolute acoustic absorption). The fourth modality is: (4) a new, advanced, thermoacoustic imaging modality, which images electrical conductivity at higher spatial resolution than heretofore possible and allows the discrimination of cancer vs. fibroadenoma (which mammography and present clinical ultrasound distinguish poorly). The first modality provides improved imaging over standard clinical ultrasound because of its: uniform high spatial resolution (B-scan resolving power falls of inversely with range), operator independence, true 3-D images, improved contrast resolution and correction for refraction and absorption. The second and third modalities provide the advanced features given by the first, plus: perfect spatial registration; absolution quantitative rendering of tissue sound speed and absorption coefficient; elimination of multiple scattering artifacts and speckle; and potential for improved resolution to one half wavelength. The combination of four modes synergistically improves diagnosis and screening. The fourth modality is improved by making amplitude and phase corrections derived from the second and third modalities. One in every 7 women will develop breast cancer in her lifetime. However, present diagnostic specificity for cancer detection (using mammography) is poor, with 3 in 4 biopsies yielding benign tissue. This proposal, which combines two novel techniques for breast cancer detection?namely Thermoacoustic Emission and Ultrasound Inverse Scattering?has a tremendous potential for improving breast cancer detection.

描述（由申请人提供）：热声和逆散射乳腺癌扫描仪摘要：我们提出了一种新的，混合，乳腺癌诊断成像系统，利用提高电导率。该系统结合了三种先进的超声成像方法和热声成像。新的超声成像方法是：（1）反射超声断层扫描模态（成像声阻抗梯度）;（2）超声逆散射模态，成像绝对声速）;（3）超声逆散射模态，成像绝对声吸收）。第四种模式是：（4）一种新的、先进的热声成像模式，其以比迄今为止可能的更高的空间分辨率对电导率进行成像，并且允许区分癌症与纤维腺瘤（乳房X线照相术和目前的临床超声区分较差）。第一种模态提供了优于标准临床超声的改进的成像，因为其：均匀的高空间分辨率（B扫描分辨率与范围成反比福尔斯）、操作者独立性、真实的3-D图像、改进的对比度分辨率以及折射和吸收校正。第二种和第三种模式提供了第一种模式所提供的先进功能，加上：完美的空间配准;组织声速和吸收系数的绝对定量渲染;消除多重散射伪影和斑点;以及将分辨率提高到半波长的潜力。四种模式的结合协同改善了诊断和筛查。第四模态通过进行从第二模态和第三模态导出的幅度和相位校正来改进。每7名女性中就有1人会在一生中患上乳腺癌。然而，目前癌症检测的诊断特异性（使用乳房X线摄影）很差，4次活检中有3次产生良性组织。这项提案结合了两种新的乳腺癌检测技术？即热声发射和超声逆散射在改善乳腺癌检测方面有着巨大的潜力。