Context Processing and Reorganization of Spatial Coding

空间编码的上下文处理和重组

• 批准号: 6797150
• 负责人: David M. Smith
• 金额: $ 4.89万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-28 至 2005-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797150
• 关键词: behavior test; behavioral /social science research tag; cognition; hippocampus; laboratory rat; learning; limbic system; memory; neural information processing; neural plasticity; neuroanatomy; neurons; neuropharmacology; postdoctoral investigator; psychobiology; psychopharmacology; single cell analysis; thalamus

DESCRIPTION (provided by applicant): The proposed research examines the learning and memory functions of limbic brain circuitry involving the hippocampus, retrosplenial cortex, and the anterior and lateral dorsal thalamus. Pathology in these regions has been associated with the human cognitive impairments seen in amnesic syndromes and Alzheimer's disease. The specific goal is to examine the contributions these regions make to contextual learning. It is proposed that these regions function cooperatively to encode the cognitive and behavioral features of a learning context and thereby provide a basis for determining appropriate behaviors in different learning situations. To assess this, multi-site neuronal recording and temporary inactivation techniques will be employed while rats learn to obtain food rewards in two different learning contexts.

描述（由申请人提供）： 这项研究旨在探讨海马、压后皮质、前丘脑和背侧丘脑的边缘脑回路的学习和记忆功能。这些区域的病理学与在遗忘综合征和阿尔茨海默病中看到的人类认知障碍有关。具体的目标是检查这些区域的贡献，使上下文学习。有人建议，这些区域的功能合作编码的认知和行为特征的学习环境，从而提供了一个基础，以确定适当的行为在不同的学习情况。为了评估这一点，将采用多位点神经元记录和暂时失活技术，同时大鼠在两种不同的学习环境中学习获得食物奖励。