NEURAL MEDIATION OF CONTEXT APPROPRIATE BEHAVIOR

描述(改编自申请人的摘要)： 建议的研究是确定和表征神经生理学 某些与上下文相适应的行为的基础。自学习以来 语境在正常的学习和记忆中扮演着重要的角色，发展 理解特定背景下的神经机制 行为是了解大脑如何运作的重要一步 供将来使用的信息。更具体地说，这个项目试图测试 假设海马体将上下文信息发送给 扣带丘脑系统产生特殊的神经元活动模式， 调解歧视中的上下文适当的关联和行为 学习范式。这将通过记录以下活动来实现 扣带丘脑回路中的神经元与对照组和对照组动物的行为 有暂时性和永久性海马区损伤的兔子 在不同的学习环境中执行两种不同的辨别性学习任务 环境。

DESCRIPTION (Adapted from applicant's abstract): The overall goal of the proposed research is to identify and characterize the neurophysiological substrates of certain context-appropriate behaviors. Since the learning context plays an important role in normal learning and memory, developing an understanding of the neuronal mechanisms that underlie context-specific behavior is an important step towards understanding how the brain processes information for future use. More specifically, this project seeks to test the hypothesis that the hippocampus signals contextual information to the cingulothalamic system to produce special patterns of neuronal activity that mediate context appropriate associations and behaviors in a discrimination learning paradigm. This will be accomplished by recording the activity of neurons in cingulothalamic circuitry and the behavior of control rabbits and rabbits with temporary and permanent lesions of the hippocampus while they perform two different discriminative learning tasks in different environments.