NEURAL MEDIATION OF CONTEXT APPROPRIATE BEHAVIOR

情境适当行为的神经调节

• 批准号: 6185118
• 负责人: David M. Smith
• 金额: $ 2.85万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-17 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6185118
• 关键词: association learning; avoidance behavior; behavioral /social science research tag; brain electrical activity; cingulate gyrus; cues; discrimination learning; experimental brain lesion; hippocampus; laboratory rabbit; memory; neural information processing; performance; training

DESCRIPTION (Adapted from applicant's abstract): The overall goal of the proposed research is to identify and characterize the neurophysiological substrates of certain context-appropriate behaviors. Since the learning context plays an important role in normal learning and memory, developing an understanding of the neuronal mechanisms that underlie context-specific behavior is an important step towards understanding how the brain processes information for future use. More specifically, this project seeks to test the hypothesis that the hippocampus signals contextual information to the cingulothalamic system to produce special patterns of neuronal activity that mediate context appropriate associations and behaviors in a discrimination learning paradigm. This will be accomplished by recording the activity of neurons in cingulothalamic circuitry and the behavior of control rabbits and rabbits with temporary and permanent lesions of the hippocampus while they perform two different discriminative learning tasks in different environments.

描述（改编自申请人摘要）： 建议的研究是识别和表征神经生理学 特定情境行为的基质。 自从学习 背景在正常的学习和记忆中发挥着重要作用，发展一种 理解特定情境下的神经机制 行为是理解大脑如何处理 供将来使用的信息。 更具体地说，该项目旨在测试 海马体向大脑发出背景信息的假设， 扣带丘脑系统产生特殊的神经元活动模式， 调解歧视中的情境适当联想和行为 学习范式 这将通过记录 扣带丘脑回路神经元和对照兔的行为， 暂时性和永久性海马损伤的兔子， 执行两个不同的区别性学习任务， 环境.