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Hippocampus, Retrosplenial Cortex and Contextual Learning and Memory

海马、压后皮质与情境学习和记忆

基本信息

批准号：
10326364
负责人：
David M. Smith
金额：
$ 40.85万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-02 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10326364
关键词：
Address Affect Alzheimer&apos s Disease Amnesia Anatomy Animals Anterior Anxiety Brain Brain region Code Color Communication Cues Data Environment Exhibits Foundations Funding Goals Hippocampus (Brain)Human Impairment Individual Investigation Knowledge Learning Learning Disabilities Link Literature Location Mediating Memory Memory Loss Memory impairment Mental Depression Methods Monitor Navigation System Neurobiology Neurons Neurosciences Odors Patients Physiological Play Procedures Process Property Psychopathology Public Health Rattus Research Research Personnel Role Schizophrenia Structure Syndrome System Thalamic structure Work age related cingulate cortex designer receptors exclusively activated by designer drugs experimental study information processing neurochemistry neuromechanism neuropathology neurophysiology optogenetics response therapy development treatment strategy way finding

项目摘要

Project Summary/Abstract This project is aimed at understanding the neural mechanisms of learning and memory. An extensive literature has documented the role of the hippocampus, retrosplenial cingulate cortex and anterior thalamus in memory functions. Damage to these brain regions is a primary cause of the memory impairments seen in Alzheimer's disease, age-related memory decline, and various human amnesic syndromes and learning disabilities. Abnormalities in these structures have also been implicated in depression, anxiety and schizophrenia. Understanding the function of these systems is crucial for the development of treatment strategies for patients with these conditions. The memory role of the hippocampus has been well documented and, although they have not been studied as extensively, the retrosplenial cortex and anterior thalamus are also known to play a critical role in learning and memory. However, the precise contribution of each of these brain regions to the learning process remains unclear. Recent findings suggest that these closely interconnected structures form a functional circuit which mediates spatial and contextual memory. The proposed experiments are focused on understanding how memory-related information is represented by neurons in the retrosplenial cortex, and how interactions of the retrosplenial cortex, hippocampus and anterior thalamus support memory functions. In order to investigate this, neuronal activity will be recorded in these brain regions as rats perform various spatial and contextual memory tasks. Optogenetic, chemogenetic and neurochemical methods will be used to suppress neuronal activity in various components of this circuit in order to assess their contributions to functioning in the broader memory circuit. By monitoring neuronal responses as subjects learn and the effects of temporary inactivation within the circuit, it will be possible to determine how memory related information is processed and how memory may fail when damage occurs within the circuit.

项目概要/摘要该项目旨在了解学习和记忆的神经机制。广泛的文献记载了海马、压后扣带皮层和前丘脑在记忆功能。这些大脑区域的损伤是导致记忆障碍的主要原因阿尔茨海默病、与年龄相关的记忆力衰退以及各种人类遗忘综合症和学习残疾。这些结构的异常也与抑郁、焦虑和抑郁有关。精神分裂症。了解这些系统的功能对于治疗的发展至关重要针对患有这些疾病的患者的策略。海马体的记忆作用已被充分记录并且，虽然尚未对它们进行广泛的研究，但压后皮质和前丘脑众所周知，它在学习和记忆中发挥着至关重要的作用。然而，每一项的具体贡献参与学习过程的大脑区域仍不清楚。最近的研究结果表明，这些密切相互连接的结构形成了一个功能回路，可以调节空间和情境记忆。这提出的实验侧重于理解与记忆相关的信息是如何表示的压后皮质中的神经元，以及压后皮质、海马和前皮质之间的相互作用丘脑支持记忆功能。为了研究这一点，神经元活动将被记录在这些大鼠执行各种空间和情境记忆任务时的大脑区域。光遗传学、化学遗传学和将使用神经化学方法来抑制该回路各个组件中的神经元活动，以便评估它们对更广泛的记忆回路功能的贡献。通过监测神经元反应受试者学习和电路内暂时失活的影响，将有可能确定如何处理与存储器相关的信息，以及当电路内发生损坏时存储器如何失效。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Slow stabilization of concurrently acquired hippocampal context representations.

同时获得的海马上下文表征的缓慢稳定。

DOI：
10.1002/hipo.22656
发表时间：
2016
期刊：
Hippocampus
影响因子：
3.5
作者：
Law,LMatthew;Bulkin,DavidA;Smith,DavidM
通讯作者：
Smith,DavidM

Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination.

DOI：
10.1002/hipo.20958
发表时间：
2012-05
期刊：
HIPPOCAMPUS
影响因子：
3.5
作者：
Smith, David M.;Barredo, Jennifer;Mizumori, Sheri J. Y.
通讯作者：
Mizumori, Sheri J. Y.

Hippocampal context processing is critical for interference free recall of odor memories in rats.

DOI：
10.1002/hipo.20953
发表时间：
2012-04
期刊：
HIPPOCAMPUS
影响因子：
3.5
作者：
Butterly, Dan A.;Petroccione, Maurice A.;Smith, David M.
通讯作者：
Smith, David M.

The medial prefrontal cortex is needed for resolving interference even when there are no changes in task rules and strategies.

即使任务规则和策略没有变化，内侧前额叶皮层也需要解决干扰。

DOI：
10.1037/bne0000347
发表时间：
2020
期刊：
Behavioral neuroscience
影响因子：
1.9
作者：
Peters,GregoryJ;Smith,DavidM
通讯作者：
Smith,DavidM

The hippocampus, medial prefrontal cortex, and selective memory retrieval: evidence from a rodent model of the retrieval-induced forgetting effect.

DOI：
10.1002/hipo.22291
发表时间：
2014-09
期刊：
HIPPOCAMPUS
影响因子：
3.5
作者：
Wu, Jade Q.;Peters, Greg J.;Rittner, Pedro;Cleland, Thomas A.;Smith, David M.
通讯作者：
Smith, David M.