ASU-UAB EXPORT Project REAP

ASU-UAB 出口项目 REAP

• 批准号: 6795080
• 负责人: KARYN D SCISSUM GUNN
• 金额: $ 22.7万
• 依托单位: ALABAMA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795080
• 关键词: African American; Hispanic Americans; Native Americans; adolescence (12-20); behavioral /social science research tag; health science research support; medically underserved population; minority institution research support; reproduction; young adult human (21-34)

DESCRIPTION (provided by applicant): Alabama State University (ASU) and The University of Alabama at Birmingham (UAB), with the cooperation of community organizations and state health agencies, propose a partnership to establish a Resource-Related Research program (R24) through funding from the National Center for Minority Health Disparities (NCMHD)/National Institutes of Health (NIH). Funding is requested for three (3) years to fund the partnership at a total of $979,043. The overall Goal of the proposed EXPORT Project is to advance the mission and vision of the NCMHD to reduce and ultimately eliminate minority health disparities in America. The ASU-UAB EXPORT Project will employ an interdisciplinary approach to develop a solid behavioral and biomedical research base to address a significant and well-documented need among ethnic minority groups, reproductive health and health disparities. The proposed project will operate as the ASU-UAB EXPORT Project REAP (Reproductive Health Disparities Awareness and Prevention), and will focus upon reproductive health disparities among minority adolescents and young adults ages 10-24 years old. The ASU-UAB Project REAP will operate from four distinct but intercommunicating Cores: Through the Feasibility Studies Pilot Research Core, one biomedical pilot research project will assess the feasibility of further development of a genetically engineered mucosally-administered STD vaccine against chlamydial infection (Project 1). Two behavioral feasibility studies will be conducted that are collectively aimed at further defining individual and socio-behavioral risk factors associated with the reproductive disparity profiles documented in the geographic target region (Montgomery, Alabama)(Project 2, NYSP Youth and Parents; Project 3, ASU Freshmen Students). These studies will address important scientific questions impacting STD vaccine development, provide preliminary data for the development of a theory-based multilevel behavioral intervention, assess the perceptions of teens, parents and young adults on reproductive health disparities issues, intervention programs, and on emerging preventive approaches such as STD vaccination. A Community Outreach Information Dissemination Core aims to collect data from state public service announcement (PSA) directors and school system administrators via public opinion polling infrastructure operated by ASU on the perceived climate regarding culturally sensitive broadcast and print media information dissemination on reproductive health issues target for Alabama's youth. A Mentoring Core aims to provide a structured pipeline of opportunity for ASU junior research faculty to further develop their research background through a unique opportunity to study with internationally acclaimed UAB research programs. The Administrative Core, in conjunction with the External Advisory and Research Committees, aims to facilitate coordinated operation of all Core activities, and to assure maximum utilization of the Project's findings and compiled information. ASU, the proposed home site of the ASU-UAB Project REAP, is located in Montgomery, Alabama, and is the second largest MSI in the state of Alabama. UAB is a Research I institution with internationally acclaimed research programs. Montgomery, Alabama fulfills the demographic goals of Project EXPORT: Montgomery County reports an African American population of 48.4%, with a total ethnic minority population of 51%, including Hispanic and Native American residents. This well-designed developmental project establishes a strong foundation for specialized reproductive health disparities research and outreach, while strengthening the resources and collaborative linkages between ASU and UAB.

描述（由申请人提供）：阿拉巴马州立大学 (ASU) 和阿拉巴马大学伯明翰分校 (UAB) 在社区组织和州卫生机构的合作下，提议建立伙伴关系，通过国家少数族裔健康差异中心 (NCMD)/国立卫生研究院 (NIH) 的资助建立资源相关研究计划 (R24)。请求为该伙伴关系提供三 (3) 年的资金，总额为 979,043 美元。拟议的出口项目的总体目标是推进 NCMHD 的使命和愿景，以减少并最终消除美国少数族裔的健康差距。亚利桑那州立大学-阿拉巴马大学出口项目将采用跨学科方法来建立坚实的行为和生物医学研究基础，以满足少数民族群体、生殖健康和健康差异的重大且有据可查的需求。拟议的项目将作为 ASU-UAB EXPORT 项目 REAP（生殖健康差异意识和预防）运作，并将重点关注 10-24 岁少数民族青少年和年轻人的生殖健康差异。 ASU-UAB 项目 REAP 将由四个不同但相互沟通的核心运作：通过可行性研究试点研究核心，一个生物医学试点研究项目将评估进一步开发一种针对衣原体感染的基因工程粘膜给药 STD 疫苗的可行性（项目 1）。将进行两项行为可行性研究，共同旨在进一步确定与地理目标区域（阿拉巴马州蒙哥马利）记录的生殖差异概况相关的个人和社会行为风险因素（项目 2，NYSP 青少年和家长；项目 3，亚利桑那州立大学新生）。这些研究将解决影响性病疫苗开发的重要科学问题，为开发基于理论的多层次行为干预提供初步数据，评估青少年、父母和年轻人对生殖健康差异问题、干预计划以及性病疫苗接种等新兴预防方法的看法。社区外展信息传播核心旨在通过亚利桑那州立大学运营的民意调查基础设施，从州公共服务公告 (PSA) 主管和学校系统管理员收集数据，了解针对阿拉巴马州青年的生殖健康问题的文化敏感广播和印刷媒体信息传播的感知氛围。指导核心旨在为亚利桑那州立大学的初级研究教师提供结构化的机会，通过与国际知名的 UAB 研究项目一起学习的独特机会，进一步发展他们的研究背景。行政核心与外部咨询和研究委员会一起，旨在促进所有核心活动的协调运作，并确保最大限度地利用项目的调查结果和汇编的信息。亚利桑那州立大学 (ASU) 是 ASU-UAB 项目 REAP 的拟建基地，位于阿拉巴马州蒙哥马利，是阿拉巴马州第二大 MSI。 UAB 是一所研究机构，拥有国际知名的研究项目。阿拉巴马州蒙哥马利实现了“出口项目”的人口目标：蒙哥马利县报告非裔美国人人口占 48.4%，少数族裔总人口占 51%，其中包括西班牙裔和美洲原住民居民。这个精心设计的发展项目为专门的生殖健康差异研究和推广奠定了坚实的基础，同时加强了亚利桑那州立大学和阿拉巴马大学之间的资源和合作联系。

项目成果

Mucosal immunization with recombinant MOMP genetically linked with modified cholera toxin confers protection against Chlamydia trachomatis infection.

使用与改良霍乱毒素基因相关的重组 MOMP 进行粘膜免疫可预防沙眼衣原体感染。

• DOI: 10.1016/j.vaccine.2005.08.097
• 发表时间: 2006
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: Singh,ShreeR;Hulett,Kara;Pillai,ShreekumarR;Dennis,VidaA;Oh,MK;Scissum-Gunn,Karyn
• 通讯作者: Scissum-Gunn,Karyn