GENETIC & ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGING

拟议研究的主要目的是利用 国家老龄问题研究所（AGO 4563）的初始投资， 1984年启动了唯一的纵向行为遗传分析， 在以后的生活中发挥作用的个体差异。 这项研究被称为 瑞典收养/双胞胎老龄化研究（SATSA），使用强大的 双胞胎一起长大，双胞胎分开阅读的设计，已经成为一个 老年遗传学的里程碑式研究 SATSA现在有机会 研究这个独特的样本十年后，通过纳入一个 第三波现场测试（IPT 3）和第四波问卷调查 评估（Q4）。 大约600人将在IPT 3中接受测试， 2,000人将获得Q4。 纵向数据收集 包括健康和与健康有关行为措施， 营养状况、日常生活活动、功能能力，以及 认知. 问卷调查阶段包括自我感知的损害， 与健康相关的结果，个性和环境措施 包括生活事件，社会支持，社会经济地位和 家庭环境。 SATSA强大的采用/孪生设计提供了 分析遗传和环境问题的令人信服的基础 对生物行为老化的变化和连续性的贡献。 将SATSA扩展到三个测量场合， 定量遗传分析的研究问题有关的形状 生长曲线，如遗传因素对终端的重要性 功能能力下降和降低。 三个测量点 为审查结构改革提供更适当的基础， 生物行为领域内和之间的测量关系。 因此，在本发明中， 分析还将涉及评估 遗传和环境因素介导了 老年人的健康、认知和福祉。 更精细的分析 发展转折点的病因学和机制 有助于纵向稳定性和变化将成为可能， 包括第四次。 预测关系，例如 生活事件和社会支持对认知和健康的影响 在随后的场合，结果也将是研究的对象。

The primary purpose of the proposed research is to capitalize on an initial investment of the National Institute on Aging (AGO4563) which in 1984 launched the only longitudinal behavioral genetic analysis of individual differences in functioning later in life. The study, called the Swedish Adoption/Twin Study of Aging (SATSA), uses the powerful design of twins reared together and twins read apart, and has become a landmark study of gerontological genetics. SATSA now has the opportunity to study this unique sample a decade later through the inclusion of a third wave of in-person testing (IPT3) and a fourth wave of questionnaire assessment (Q4). Approximately 600 individuals will be tested in IPT3, and 2,000 individuals will receive Q4. Longitudinal data to be collected in IPT include measures of health and health-related behavior, nutritional status, activities of daily living, functional capacity, and cognition. The questionnaire phase covers self-perceived impairment due to health-related outcomes, personality, and measures of the environment including life events, social support, socioeconomic status and the family environment. The powerful adoption/twin design of SATSA provides a compelling basis for analyzing issues of genetic and environmental contributions to change and continuity in biobehavioral aging. Extension of SATSA to three measurement occasions will enable quantitative genetic analyses of research issues related to the shape of growth curves, such as the importance of genetic factors for terminal decline and reduction in functional capacity. Three points of measure provide a more appropriate basis for examining structural change in the relationship of measures within and between biobehavioral domains. Thus, analyses will also be concerned with assessing the extent to which genetic and environmental factors mediate the relationship between health, cognition and well-being in the elderly. More refined analyses of the etiology of developmental turning-points and the mechanisms contributing to longitudinal stability and change will be possible with the inclusion of a fourth occasion. Predictive relationships, such as the impact of life events and social support on cognitive and health outcomes at subsequent occasions, will also be the object of study.